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Biomedical subjects

H Oda

Publications and source records attributed to H Oda.

At least 469 records · Page 26Linked to original sources
PubMed1985

[VM-26 salvage therapy for refractory or recurrent germinal testicular cancers].

Four patients with refractory or recurrent germinal testicular cancers were treated with the combination of VM-26 and cis-platinum, and two of them also in combination with radiation therapy. Two complete responses and two partial responses were observed. One partial response was rendered no evidence of disease by sequential radiation therapy. Three of the patients remained to have no evidence of disease from 16, 21 and 22 months. Toxicity was tolerable. VM-26 is an active drug in germinal testicular cancers and plays an important role in salvage therapy, for refractory or recurrent cases.

Adult↗
PubMed1984

Pedunculated hepatoma--report of two cases and review of the literature.

Although pedunculated hepatoma has received little attention in the United States and Europe, in Japan more than forty cases have been reported, probably owing to the relatively high frequency of hepatoma. Formerly preoperative diagnosis was difficult in the early period. Recently it can be made by ultrasound, computed tomography and angiography, however, the choice of operative procedure is not uniform. In some cases good results were obtained by only tumor excision or partial hepatic resection, whereas other cases presented undergoing more extended resection show a poorer course. In the present case 1, intrahepatic recurrence was recognized three months after surgery in spite of relatively early diagnosis. Reviewing the literature, it appears that the degree of invasion at the pedicle is mainly related to prognosis. If invasive, segmentectomy or lobectomy is necessary and postoperative adjuvant therapy is needed.

Carcinoma, Hepatocellular↗
PubMed1984

7 alpha-Dehydroxylation of bile acids by resting cells of a Eubacterium lentum-like intestinal anaerobe, strain c-25.

7 alpha-Dehydroxylation of cholic acid and chenodeoxycholic acid by whole cells of strain c-25, a Eubacterium lentum-like intestinal anaerobe, was studied. 7 alpha-Dehydroxylase activity was observed only in whole cells grown in the presence of the primary bile acid (cholic acid or chenodeoxycholic acid). Chenodeoxycholic acid was twice as effective as cholic acid as an inducer. Although cells grown in the presence of chenodeoxycholic acid had no significant substrate specificity for the two primary bile acids, cells grown in the presence of cholic acid showed two times greater activity against cholic acid than chenodeoxycholic acid. Exposure of cell suspensions to atmospheric oxygen resulted in little loss of the 7 alpha-dehydroxylase activity. The induced enzyme had an optimal pH range of 7.3 to 7.7. Although adding flavin mononucleotide to the growth medium significantly increased the 7 alpha-dehydroxylation of bile acids without an increase in cell growth, inhibition of the enzyme activity was observed in the resting cell system when flavin mononucleotide was included in the reaction mixture.

Animals↗
PubMed1984

[A case of vesical malacoplakia].

A 44-year-old woman was admitted to our hospital, complaining of terminal hematuria. On cystoscopy four yellow and soft nodular masses were observed in the bladder, one of which had central ulceration. TUR was performed for these masses. Histological examination revealed that they were vesical malacoplakia. The masses consisted of aggregates of macrophages with abundant cytoplasma in which typical Michaelis-Gutmann bodies were demonstrated by light and electron microscopies.

Adult↗
PubMed1984

Renal haemodynamics and the renin-angiotensin system in adolescents genetically predisposed to essential hypertension.

Relationships between renal haemodynamics and the renin-angiotensin system were examined in 128 male adolescents with differing predispositions to hypertension. Baseline renal vascular resistance (RVR) was significantly elevated in the normotensive subjects with a positive family history, NT (FH+) group, than in the normotensives with a negative family history, NT (FH-) group, while there were no significant differences in other characteristics between the two groups. The borderline hypertensive subjects with a positive family history, BH (FH+) group, showed an even bigger increase in RVR and also had elevated plasma renin activity (PRA). In the NT (FH+) and BH (FH+) groups RVR correlated significantly with PRA levels. When captopril was given, the increased RVR in the NT (FH+) and BH (FH+) groups decreased, in correlation with baseline PRA, to levels not significantly different from those in the NT (FH-) group, in which no significant changes occurred in RVR. These results suggest that RVR may increase primarily in adolescents genetically predisposed to essential hypertension and that the renin-angiotensin system may play an important role in the mechanism of this increase in RVR.

Adolescent↗
PubMed1984

Soft tissue collagen in congenital dislocation of the hip. Biochemical studies of the ligamentum teres of the femur and the hip joint capsule.

Collagens of the ligamentum teres of the femur and the hip joint capsule of 14 patients with congenital dislocation of the hip (CDH) were studied biochemically. Collagen was a major component of these tissues. Solubility of collagen was reversely related to age except in two cases. Collagen of both ligamentum teres of the femur and hip joint capsule was composed of type I, III and V collagens except in three cases. In these three cases with nevus or general joint laxity, two additional collagenous components were also found. The ratios of type III collagen to type I collagen were increased in CDH except in one case with short stature. These abnormalities of collagen metabolism could be the underlying cause of CDH and other clinical symptoms in these patients.

Amino Acids↗
PubMed1983

Purification and characterization of NADP-dependent 7 beta-hydroxysteroid dehydrogenase from Peptostreptococcus productus strain b-52.

An NADP-dependent 7 beta-hydroxysteroid dehydrogenase was purified 11.5-fold over the activity in crude cell extracts prepared from Peptostreptococcus productus strain b-52, by using Sephadex G-200 and DEAE-cellulose column chromatography. 7 beta-Dehydrogenation was the sole transformation of bile acids catalyzed by the partially purified enzyme. The enzyme preparation (spec. act. 2.781 IU per mg protein) had an optimum pH of 9.8. Lineweaver-Burk plots showed a Michaelis constant (Km) value of 0.05 mM for 3 alpha, 7 beta-dihydroxy-5 beta-cholanoic acid whereas higher values were obtained with 3 alpha,7 beta-dihydroxy-5 beta-cholanoyl glycine (0.20 mM), and 3 alpha,7 beta-dihydroxy-5 beta-cholanoyl taurine (0.26 mM). NADP but not NAD could function as an electron acceptor, and had a Km value of 0.30 mM. A molecular weight of 64000 was determined by SDS-polyacrylamide gel electrophoresis. The addition of 0.4 mM of either bile acid to the growth medium suppressed not only cell growth, but also the enzyme yield.

Hydrogen-Ion Concentration↗
PubMed1983

7 alpha-Dehydroxylation of bile acids by resting cells of an unidentified, gram-positive, nonsporeforming anaerobic bacterium.

Transformation of bile acids by washed whole cells of strain HD-17, an unidentified gram-positive anaerobic bacterium isolated from human feces, was studied. 7 alpha-Dehydroxylase was produced only during adaptive growth on medium containing 7 alpha-hydroxy bile acids. Both the extent of hydroxylation and the state of conjugation of the bile acids had marked effects on the induction of the enzyme, and the order of the enzyme induction was conjugated cholic acid much greater than cholic acid greater than taurochenodeoxycholic acid greater than or equal to chenodeoxycholic acid. The addition of excess glucose to the growth medium appreciably reduced the enzyme level. The induced enzyme required strict anaerobic conditions for activity and had an optimal pH range of 6.5 to 7.5. In contrast with the induction of the enzyme, the induced enzyme showed a low degree of substrate specificity between cholic acid and chenodeoxycholic acid, with some preference for the former. In addition, the organism contained 3 alpha-, 7 alpha-, and 12 alpha-hydroxysteroid dehydrogenases, and the addition of bile acids to the medium somewhat enhanced the production of the oxidoreductases. The dehydrogenations were obviously stimulated by oxygen as a terminal electron acceptor. The organism also contained bile salt hydrolase.

Aerobiosis↗