Search PubMed⌕ Search

Biomedical subjects

H Noel

Publications and source records attributed to H Noel.

At least 37 records · Page 2Linked to original sources
PubMed1990

1,25-Dihydroxyvitamin D-related hypercalcemia in lymphoma: two case reports.

We report two patients with non-Hodgkin's lymphoma in whom hypercalcemia and elevated 1,25 dihydroxyvitamin D (1,25-(OH)2D3) levels developed in the absence of any lytic bone lesions. Hypercalcemia responded only transiently to glucocorticoids which were ill tolerated. Intravenous APD administration was needed to circumvene hypercalcemia. Humoral hypercalcemia of malignancy is discussed. Our cases confirm that hypercalcemia associated with elevated 1,25-(OH)2D3 may occur in malignant lymphoma.

Aged↗
PubMed1990

Beta 2-microglobulin amyloidosis in a patient treated exclusively by continuous ambulatory peritoneal dialysis.

The histological demonstration of beta 2-microglobulin (B2M) amyloidosis in a 75-year-old man treated exclusively by continuous ambulatory peritoneal dialysis (CAPD) for 87 months is reported. Amyloid deposits were detected in all joints from which synovial specimens were obtained at autopsy. It is of note that the patient had never undergone hemodialysis and had suffered only one episode of peritonitis. Both features are of interest, as the few reports of dialysis-related amyloidosis (DRA) in CAPD include patients who have been hemodialyzed and have suffered repeated episodes of peritonitis, both conditions being incriminated in the genesis of B2M amyloidosis. We conclude that DRA may develop in the absence of artificial membranes or frequent peritonitis episodes.

Aged↗
PubMed1989

Spontaneous healing of aneurysmal bone cysts. A report of three cases.

We report three cases of spontaneous healing of aneurysmal bone cysts (ABC). In one case histological material was obtained after resection of the already ossified expansile mass discovered as a lytic lesion seven months previously. In the two other patients, spontaneous ossification of a radiologically presumed ABC in the lytic and expansile phase was observed after nine and seven months respectively. The healed lesions have remained stable at 12, 32, and 36 months respectively. These findings suggest that when the diagnosis can be made with confidence, and the lesion is in a location and at a stage that does not entail any risk of fracture or compression, expectant management should be considered. Our three patients were aged 22, 19 and 18 years, older than usual for developing ABC. This is also true for many of the few other reported cases of spontaneous or almost spontaneous healing and suggests that ABC has a greater tendency to stabilise in older patients.

Adolescent↗
PubMed1987

[Non-Hodgkin lymphomas of the larynx. Apropos of a case].

In connection with a recent observation of laryngeal lymphoma, we have looked through the literature and listed 79 cases. Preferentially, these are male subjects over fifty years of age. The symptoms are slowly progressive dyspnea and unilateral otalgia. Laryngoscopy shows a smooth-surfaced tumour, regular in shape and pinkish grey in colour, generally localized at the supra-glottic level. Therapeutic strategy is closely linked with histologic investigation and the stages of progression. Treatment is based on radiotherapy to the affected area, associated with chemotherapy in the case of extralaryngeal lymphomatous involvement. While prognosis remains good in the case of an isolated laryngeal attack, it is less so in the case of multiple localization.

Aged↗
PubMed1986

Cutaneous mucinosis associated with multiple frozen joints and bony heterotopic deposits around the hips.

A 43-year-old man suffered from migrating then additive arthralgias associated with macroscopic and microscopic cutaneous lesions compatible at first sight with reticular erythematous mucinosis. After nine months, the cutaneous picture evolved into a papular mucinosis. The patient developed "multiple frozen joints" with heterotopic bony deposits around the hips. To our knowledge, such articular problems have not yet been described in this condition. Severe systemic complications prompted the authors to treat the patient with plasma exchange and melphalan.

Adult↗
PubMed1985

Primary cardiac liposarcoma simulating a left atrial myxoma.

This paper reports the case of cardiac tumor which had been diagnosed as a left atrial myxoma but which later on was identified as being a primary cardiac liposarcoma. The clinical characteristics of cardiac liposarcomas, the problems of differential diagnosis, the prognosis and therapy are reviewed.

Diagnosis, Differential↗
PubMed1984

Unusual aspects of synovial chondromatosis of the elbow.

A 60-year-old man suffered locally from a rather aggressive chondromatosis of the elbow. Clinically the presentation was rather uncommon, with some radiological aspects (juxta-articular bone rarefaction) differing from those of ordinary chondromatosis. Neither the pathologist nor the radiologist recognized signs of malignancy. Regional osteoporosis, although rarely described in synovial chondromatosis, was considered as the diagnosis in this patient, but a low grade primitive chondrosarcoma must be sought in such cases.

Bone Neoplasms↗
PubMed1984

Paget's sarcoma--with two illustrative cases.

Two cases of Paget's sarcoma of bone are described. The first one is mainly characterized by the almost simultaneous degeneration of the only two existing locations of the underlying Paget's disease. The second case is one of monostotic Paget's disease of the scapula disclosed by the malignant degeneration.

Aged↗
PubMed1977

Use of miconazole for prevention of opportunistic fungal infection during treatment of haematological malignancies.

It appears that miconazole is highly effective in reducing the incidence of systemic mycosis in patients suffering from malignant haemopathy and bone marrow failure. Three clinical infections (one stomatitis and two septicaemias due to candida) were easily cured. Autopsy findings never disclosed mycosis as the cause of death. The drug was completely atoxic and seems to offer major help in the treatment of malignant blood disease.

Adolescent↗
PubMed1977

[Ultrastructure of achromic malignant melanoma of the gingiva. value in differential diagnosis].

The authors report a case of a large oral tumour. On the basis of classical histological and histochemical techniques, the diagnosis was oriented towards an angiosarcoma though it was not possibile to eliminate an achromic melanoma. Ultrastructural studies demonstrated the presence of premelanosomes and established the diagnosis of an achromic malignant melanoma. The clinical interest of this approach isthus emphasised.

Aged↗
PubMed1976

Galactokinase mutants of Chinese hamster somatic cells resistant to 2-deoxygalactose.

The growth of Chinese hamster somatic cells was inhibited by 0.2 mg/cc of 2-deoxygalactose. Mutants partially or fully resistant to 2-deoxygalactose were isolated in a single-step or two-step selection. Some of them did not grow as well as the wild type; one of them which lacked galactokinase(EC.2.7.1.6) activity did not grow at all in galactose medium. The galactokinase kinetic properties (Vmax & kmax of the other mutants and of the wild type were different. Therefore resistance resulted either from the possible absence of galactokinase synthesis or from a structural mutation, possible a missence mutation, in the galactokinase gene.- A simple diagnostic test for juvenile cataract is proposed.

Cell Line↗