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Biomedical subjects

H Nemoto

Publications and source records attributed to H Nemoto.

At least 73 records · Page 4Linked to original sources
PubMed1989

[Long-term results of intra-arterial infusion therapy using cis-DDP (CDDP) in thoracic esophageal cancer].

The effects of intra arterial infusion therapy using CDDP for patients with thoracic esophageal cancer were investigated. From June 1984 to December 1988, 25 of 146 resected patients with thoracic esophageal cancer underwent preoperative therapy in our institute. All of these patients it was suspected preoperatively that their chief lesion had invaded to the aorta, trachea or main bronchi. Preoperative radio-chemotherapy with intra arterial infusion therapy was given to 10 of 25 patients (A group), and without intra arterial infusion therapy to 15 of 25 patients (B group). CDDP 75 mg was infused into the proper esophageal artery. In A group, 7 of 10 (70%) showed moderately or marked effects in histologic study, although in B group, only 4 of 15 (27%) did so. As for long-term results, the 2-year survival rates were 50% in A group and 13% in B group (Kaplan-Meier method. Preoperative intra arterial infusion therapy using CDDP with radio-chemotherapy showed markedly better effects in histologic study and survival rates than preoperative radio-chemotherapy without intra arterial infusion therapy. We consider that this therapy is very useful for controlling the local lesion in advanced esophageal cancer.

Cisplatin↗
PubMed1988

[The efficacy of combined use of 1 alpha-hydroxyvitamin D3 with calcium supplements in the treatment of osteoporosis].

Synthetic analogue of active vitamin D metabolite, 1 alpha (OH) D3, has been widely used in the treatment of osteoporosis. However, the most effective method of treatment is yet to be established. Importance of calcium supplement to improve the calcium metabolism in osteoporosis is also reported by many authors. We have studied the combined effects of 1 alpha (OH)D3 with calcium supplement in preventing progressive decrease of bone mass in patients with osteoporosis. Sixty-six cases of postmenopausal and senile osteoporosis were divided into two groups: one treated with calcium alone 1,000 mg a day and the other treated with calcium 1,000 mg and 1 alpha (OH)D3 0.5 microgram a day, and both groups were followed for 24 months. Bone mass was evaluated by microdensitometry of the roentgenograms of the second metacarpal bone. The results revealed that the combined use of 1 alpha (OH)D3 with calcium has a significantly more favorable effect than the use of calcium alone in preventing bone loss. Therefore, 1 alpha (OH)D3 with calcium is useful in the treatment of osteoporosis. The conclusion would be further confirmed with longer term study and a more accurate method of measuring bone mass.

Aged↗
PubMed1986

Action of thyrotropin-releasing hormone (TRH) on the occurrence of fibrillation potentials and miniature end-plate potentials (MEPPs). An experimental study.

The effect of TRH on fibrillation potentials and MEPPs were studied to determine the sites of action of TRH on muscle weakness. Intravenous administration of 10(-4) U thyroid-stimulating hormone (TSH) did not change the fibrillation-frequency of the denervated muscles of rats, but subsequent intravenous administration of 1 mg TRH did. Drip application of 0.6 mg TRH directly onto the denuded denervated muscles of rats did not cause an increase in fibrillation. Application of 1 mg TRH to the rat diaphragm increased the frequency of MEPPs. Both the increase in frequency of fibrillation potentials and the increase in frequency of MEPPs by application of TRH suggest that TRH influences nerve terminals, and that TRH seems suitable for treatment of muscle weakness in patients with ALS.

Animals↗
PubMed1985

Epidemiologic study of carcinoma in situ of the cervix.

From 1950 to 1979, 1,248 cases of cancer in situ were treated in the Department of Gynecology, Cancer Institute Hospital, Tokyo. Detailed data were obtained from 585 of the patients by interview. Many patients had had their first sexual experience at an early age. Many had had more than two sexual partners, and there was a large discrepancy between the age at first sexual intercourse and at first marriage. The above factors seem to be related to the development of cancer in situ.

Abortion, Legal↗
PubMed1985

[Epidemiologic study by interview on carcinoma in situ of the cervix uteri].

From 1950 to 1979, 1248 patients with cancer in situ of the cervix uteri were treated at the Department of Gynecology, Cancer Institute Hospital, Tokyo. Information was obtained from 585 of these patients by direct interview. Many patients revealed early experience of first sexual intercourse and many had had more than two sexual partners and a large discrepancy between the age at first sexual intercourse and at first marriage. Early experience of first sexual intercourse, marital status and the number of sexual partners all seem to have a relation to the development of cancer in situ.

Adult↗
PubMed1982

Insulin receptor isolation studies.

The observation that N alpha,B1-biotinylinsulin binds firmly to resins in which succinoylavidin is covalently attached to AH Sepharose 4B and can be retrieved by exposure of the resins to 20 mM biotin provided the basis for the present investigations. Solubilized, partially purified insulin receptor from human placenta binds to affinity resins in which N alpha,B1-biotinylinsulin is noncovalently attached to AH Sepharose 4B-immobilized-succinolylavidin. Exposure of the receptor loaded resin to 20 mM biotin results in liberation of a high molecular weight material containing bound 125I-biotinylinsulin, which precipitates with polyethyleneglycol and cross reacts with human insulin receptor antibodies. The technique is biospecific and appears to be applicable to the purification of insulin receptors on a preparative scale. Crude solubilized insulin receptor from human placenta is contaminated with "insulinase" which is inhibited by N-ethylmaleimide. HPLC provides a tool to assess "insulinase" activity that is more sensitive than the TCA precipitation method.

Chromatography, High Pressure Liquid↗
PubMed1982

Relationship between serotype and certain biological and biochemical characteristics of strains of the Mycobacterium avium and Mycobacterium intracellulare complex.

Some relationships among Schaefer's serotypes and biological and biochemical characteristics were observed in strains of the Mycobacterium avium-Mycobacterium intracellulare complex. Strains belonging to serotypes 2 and 16 lacked the capacity to utilize n- and iso-butanols as the sole source of carbon in the presence of ammoniacal nitrogen. However, strains of serotype 2 grew at 45 C and lacked arylsulfatase activity (after 14 days), whereas strains of serotype 16 failed to grow at 45 C and showed positive arylsulfatase activity. Strains belonging to serotypes 8, 9, and 15 grew at 45 C, utilized n- and iso-butanols, and showed arylsulfatase activity.

Arylsulfatases↗
PubMed1982

Inhibition of protein A-induced lymphocyte colony-forming cells by con A-generated suppressor cells or their culture fluid.

Concanavalin A (Con-A)-treated human lymphocytes or their culture fluid suppressed protein A-induced lymphocyte colony formation by more than 40%. The suppressor factor was produced primarily by Con A-stimulated T lymphocytes and maximal production occurred on the 2nd day of culture with 10 microgram Con A, a condition optimal for the induction of suppressor T cells. This suggests that the factors are released by suppressor T cells. We hypothesize that suppressor T cells exert a negative control on clonal proliferation of lymphocytes.

B-Lymphocytes↗