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Biomedical subjects

H Nakata

Publications and source records attributed to H Nakata.

At least 343 records · Page 19Linked to original sources

Computed tomography in calcification of ligamenta flava of the cervical spine.

A case with cervical myelopathy caused by massive calcifications of ligamenta flava is presented. The round radiopaque nodules were found on conventional cervical radiography. Following examination by computed tomography, the nodules were diagnosed as calcified ligamenta flava in the cervical spine. The findings were confirmed at surgery and by histological investigations.

Aged↗

[Complication of therapeutic transcatheter hepatic artery embolization for hepatoma--case of developing an extensive acute gastric ulcer].

We report the development of an extensive acute gastric ulcer in a 60-year-old man following therapeutic transcatheter hepatic artery embolization for hepatoma. The unintentional occlusion of branches of the right gastric artery with refluxed Gelfoam fragments is thought to be responsible. This complication is probably rare, but should be kept in mind when therapeutic embolization of the hepatic artery is performed.

Acute Disease↗

[Experimental combination chemotherapy with vincristine and carboquone in human ovarian cancer transplanted into nude mice].

The tumor killing effects of combination chemotherapy with vincristine (VCR) and carboquone (CQ) administrated either simultaneously or sequentially with time intervals of up to 36 hours were studied in serially transplantable human ovarian cancer (JOG-1) in nude mice. Using 3H-thymidine pulse labeling, some tumor cell kinetic parameters were estimated as 13.8 hours for Ts and 42.2 hours of Tc, respectively. The induction of partial synchronization after treating with VCR in vivo was confirmed by estimating both the labeling index and the mitotic index. Sequential treatment with VCR followed by CQ at intervals of 24 hours was the most effective anti-tumor schedule in this treatment system. This sequence of drug administration also resulted in either weight loss nor toxic death of the animals during the schedule. These results indicate that the sequential administration of VCR followed by CQ chemotherapy is strongly recommended for clinical application.

Animals↗

[Fractionated intracavitary radiation for glioblastoma with remote afterloading system].

Three patients harboring glioblastoma were treated by fractionated intracavitary radiation using remote afterloading system. For this therapy, a special intracranial applicator was designed and used. Radiation schedule was planned to deliver 3000 rads to the margin of the tumor in 3 fractions over 10 days. The advantages of this treatment are that complete elimination of all unnecessary radiation exposure is possible, and that placing a radioactive source in the tumor provides maximal delivery of radiation to the tumor with relative sparing of surrounding normal brain. The method of treatment is presented and discussed with the reports of the clinical cases.

Aged↗