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Biomedical subjects

H Nakata

Publications and source records attributed to H Nakata.

At least 307 records · Page 17Linked to original sources
PubMed1986

[Experimental chemotherapy of germ cell tumor heterotransplanted to nude mice].

While the treatment of ovarian cancer has made remarkable progress in recent years, the chemotherapy of ovarian germ cell tumor has not as yet been fully established and remains to be improved. We investigated the effectiveness of a single-agent therapy with Vincristine (VCR), Actinomycin D (ACD), and Cyclophosphamide (CPM) against a human undifferentiated dysgerminoma's cell line (JOHYL-1) with the following results. The ratio of the number of viable cells to the total cell population treated for JOHYL-1 cells of ascitic type was 70% with VCR, 58% with CPM and 25% with ACD; hence the efficacy on this malignant cell line was the greatest with ACD followed by VCR and CPM in that descending order. Notably with CPM, a striking antitumor effect was observed from 48 to 24 hours after treatment. The L.I. attained a peak at 24, 18 and 30 hours, respectively, after treatment with VCR, ACD and CPM. The M.I. was as high as a little more than 6% at 36 hours after treatment with VCR. There also was noted a shift in the cell cycle with any of the test drugs. Morphological changes observed in the cell were most obvious with ACD followed in order by VCR and CPM. LDH & isozyme pattern: In these respects there were no striking differences among the three drugs, even though the total enzyme activity was somewhat higher with VCR.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

[Mammography in diagnosis of breast cancer].

Radiographic features of 50 breast cancers were evaluated in comparison with 83 benign lesions and the diagnostic accuracy is discussed. Most of the usual primary and secondary findings of cancer such as spicula formation, microcalcifications, skin, thickening and nipple retraction were present in these 50 cancer lesions and all of them were recognized in the benign lesions as well, although less frequently. Because breast parenchyma was dense in 81% of the cases evaluated, and mostly due to moderate to severe dysplasia, the diagnosis of the breast lesions was difficult. Therefore, we must be cautious in calling a lesion benign. The radiographic detectability of cancer was 94%, and the diagnostic accuracy was 72%, which are comparable to the results reported from other places.

Adult↗
PubMed1985

Bilateral pericallosal arterial ectasia.

We report a rare case of ectasia of both pericallosal arteries in a non-hypertensive 37-year-old female, whose internal carotid arteries and vertebrobasilar arteries were normal. The computed tomography (CT) showed irregular calcifications in the midline in the frontal region extending to the corpus callosum, which became partially enhanced along the course of the pericallosal artery following intravenous contrast administration. The diagnosis of arterial ectasia was established by angiography.

Adult↗
PubMed1985

Computed tomography characterization of anterior mediastinal tumors.

The computed tomography manifestations of 39 patients with histologically proved anterior mediastinal tumors were studied by categorizing the tumors by content as solid homogeneous, cystic homogeneous, and heterogeneous. Among 24 solid tumors, thymomas were easily distinguished by their lack of invasiveness from malignant lymphomas and germ-cell tumors. Among 11 cystic tumors, pericardial and thymic cysts were differentiated from cystic teratomas and bronchogenic cysts by their lack of recognizable capsules with or without calcification. The differential diagnosis of a variety of tumors of the anterior mediastinum was facilitated by computed tomography in all but a few exceptional cases.

Adolescent↗
PubMed1985

Diffuse peripheral lung disease: evaluation by high-resolution computed tomography.

High-resolution computed tomography (HRCT) was performed on 15 patients who had diffuse peripheral lung disease, and the findings were compared with those of conventional chest radiography and histologic examination. Bullae, interstitial fibrosis with honeycombing, and small granulomas were more clearly and specifically demonstrated on HRCT scans than on conventional chest radiographs in all patients. Histologically proved mild alveolar wall thickening due to alveolitis in cases of sarcoidosis and systemic lupus erythematosus was not detected. HRCT is useful for performing detailed morphological analyses of abnormalities of the peripheral portions of the lung.

Adult↗
PubMed1985

Bioavailability of indomethacin capsules in humans (III): Correlation with bioavailability in beagle dogs.

The bioavailabilities of five indomethacin capsules were studied in ten beagle dogs and correlations with the in vivo results in humans and dissolution rates were investigated. The difference in bioavailability between two commercial products was smaller in dogs than in humans, which seemed to be due to strong disintegration forces in dogs. The difference in the dissolution rate among the products was reflected less in the Tmax in dogs than in humans, and the Tmax was shorter in dogs which seems to be due to faster gastric emptying and passage of the drug through the absorption site in dogs. Gastric acidity effects on the indomethacin availability found in humans were not observed in dogs. The Cmax and Tmax correlated well with the in vitro dissolution rates, but AUC24 did not. The Cmax and Tmax in dogs also correlated with the corresponding parameters in humans, especially those in high gastric acidity humans, but AUC24 did not.

Animals↗