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Biomedical subjects

H Miwa

Publications and source records attributed to H Miwa.

At least 307 records · Page 17Linked to original sources
PubMed1984

[Antitumor effect of new lymphokine OH-1 on BDF1 mice bearing Lewis lung carcinoma].

Antitumor effect of new lymphokine extracted from BALL-1 cells derived from human acute lymphocytic leukemia was investigated using BDF1 mice bearing Lewis lung carcinoma. This antitumor lymphokine is called OH-1. The antitumor effect of OK-1 on transplanted main tumor was great, but less effective than cyclophosphamide. However, the antitumor effect on OH-1 on metastatic tumor was comparably high as with cyclophosphamide, both macroscopically and functionally.

Animals↗
PubMed1984

[Identification and prognostic implication of lymphocyte infiltration in tumor tissue of cancer patients].

Cancer patients with marked lymphocytic infiltration in tumor tissue tend to have a better prognosis than those who do not. This tendency is apparent from our study of the relationship between prognosis and lymphocyte infiltration in tumor tissue and the reactions of regional lymph nodes in several malignant diseases. We used the immunofluorescent technique to determine the percentage of T lymphocytes in the infiltrating cells. We also present our results obtained by the immunoperoxidase technique using monoclonal antibodies (OKT and Leu series).

Humans↗
PubMed1983

Effect of splenectomy and immunotherapy on advanced gastric cancer associated with total gastrectomy.

Immunotherapy with levamisole (LMS) and combined splenectomy were performed in the cases of stages III and IV gastric cancer of the upper and middle stomach and associated with total gastrectomy. The cell-mediated immunity and the survival rates for both groups were compared with controls. Combined splenectomy was not effective for cases of stage III gastric cancer, but was effective for those in stage IV. Comparing the cumulative survival rates of the immunotherapy group with the controls, cases of stages III and IV gastric cancer without splenectomy, the survival rate of those with immunotherapy was higher than that of the control group in the cases of the stage III, but the result was reverse in cases of stage IV gastric cancer. Changes in the cell-mediated immunity correlated with the survival rates.

Gastrectomy↗
PubMed1983

Effects of the removal of the primary tumor and immunotherapy with Corynebacterium parvum on metastatic tumor proliferation.

The effects of surgical intervention by removal of the primary focus, and the effectiveness of an immunomodulator, Corynebacterium parvum (Cp), on the proliferation of metastatic tumor tissue were investigated by following the postoperative changes in the 3H-thymidine labelling rate of metastatic tissue in an experimental model of metastasis in mice. In addition, the delayed type hypersensitivity reaction (DTH) was studied to investigate the immune capacity of the host. The labelling rate of mice that had the primary focus removed remained high with little variation, while that of the mice not operated on decreased gradually. On the other hand, in mice undergoing a sham operation, the rate was the same as that of the mice with the primary focus removed for a short while, but then gradually decreased. When Cp was administered, especially before removal of the primary focus, the rate was lower than that of the tumor bearing control group and decreased steadily. The number of pulmonary metastatic nodules was increased by removal of the primary focus, but this increase was inhibited by the administration of Cp which prolonged life. The depression in the DTH was less in the group given Cp preoperativeLy than in either the group of mice having the primary focus removed or those not having it removed.

Animals↗
PubMed1983

Immunochemotherapy with levamisole for stage III gastric cancer patients.

Levamisole (LMS) was given to stage III gastric cancer patients starting three days before gastrectomy, at a does of 150 mg/day for three consecutive days every other week. Survival rates of these patients were compared with those of stage III gastric cancer patients previously operated in our Department who had not received levamisole. The background factors of both groups were matched as closely as possible. Both groups were concomitantly treated with mitomycin C and FT-207. The survival rate of the LMS group was significantly higher than that of the control group when the tumor had a diameter of 4.0-8.0 cm, cancer cells infiltrated to the gastric serosa, there were metastases within the regional lymph nodes, cancer cells slightly invaded the venous capillaren and there was moderate infiltration of the stroma.

Adolescent↗
PubMed1983

Splenectomy combined with gastrectomy and immunotherapy for advanced gastric cancer.

We studied the effects of a splenectomy in combination with immunotherapy on the survival of patients who had undergone a total gastrectomy. It was found that a splenectomy was not effective against advanced gastric cancer at stage III, and that the spleen should be retained for immunotherapy. Splenectomy for gastric cancer at terminal stage IV, particularly in combination with immunotherapy, produced not only augmentation of cellular immunity, but also increased survival.

Gastrectomy↗
PubMed1983

[The tumor--immunological significance of splenectomy for cancer therapy].

In animal experiment, 5 X 10(5) MH-134 tumor cells were transplanted s.c. on the back of the C3H/He mice. Three, seven, 14 and 21 days after tumor transplantation, splenectomy or sham operation were performed and the tumor growth and survival days were examined in each group. As the results, the tumor growth was inhibited and the survival days prolonged not only in the group splenectomized three days but also 21 days after tumor transplantation. Clinically, the effect of splenectomy in combination with immunotherapy on cell-mediated immunity and the survival rates were studied in the gastric cancer patients of upper and middle stomach with 90 cases of stage III and 48 cases at stage IV, totalling 138 cases who underwent total gastrectomy during 1965 and 1981. Immunotherapy was conducted with immunomodulator levamisole at a daily dose of 150 mg, three consecutive days every other week. As a result, splenectomy was not effective for advanced gastric cancer at stage III and in the patients spleen should be retained for immunotherapy. Splenectomy for gastric cancer at stage IV, particularly in combination with immunotherapy, produced augmentation of cell-mediated immunity and longer survival as well. Complications caused by splenectomy were small.

Animals↗
PubMed1983

3-D envisioning by real time perpendicular bi-plane echocardiography (simultaneous multifrequency ultrasonography-III).

Simultaneous dual B-modes, the tomographic plane of which can be moved freely keeping the intersecting angle always perpendicular, was devised and based on simultaneous multifrequency ultrasonography (Miwa, et al, 1981). Dual probes, the ends of which are linked by two arms and three nodes with potentiometers are used to display the intersecting line on the both B-mode images by computation. Both images can be displayed together on one CRT, or separately on the different CRTs. This has proved to be a great help for understanding the 3-D structure of heart. Quantitative dimension and displacement speed measurement of 3-D structure of heart such as myocardium thickness, inner diameter of ventricle, and their changing speed, can be performed very exactly at the accurate three dimensional orientation to the heart. We have also recognized that measuring beam for M-mode must be guided to an exact orientation by this technology. Otherwise, unexpected error has been introduced very usually, if guided only by conventional single B-mode due to lack of information of three dimensional incident angle to the wall, valve,..

Biophysical Phenomena↗
PubMed1983

[Antitumor effect of bacterial lipopolysaccharide (LPS) and a combination use of LPS and lentinan on C3H/He mice bearing MH-134 tumor].

Using C3H/He mice a series of experiments was carried to study the antitumor effect of lipopolysaccharide (LPS) in combined use with Lentinan extracted from Cortinellus shiitake and its influence on cellular immunity as well as antitumor effect of tumor necrosis factor (TNF) prepared from LPS, and the following results were obtained: 1) In the cases where LPS was administered when the tumor had grown to a certain extent after tumor transplantation, hemorrhagic necrosis of the tumor occurred within 48 hours, showing a high antitumor effect. 2) In the cases where LPS was used with Lentinan, i.e., 2 mg/kg/day of Lentinan was administered from the 1st to the 8th day after tumor transplantation, and 30 micrograms/kg of LPS given on the 12th day, the highest antitumor effect could be achieved. 3) By combined use of LPS and Lentinan delayed type hypersensitivity was intensified. 4) Upon application of rabbit serum containing TNF to cancer bearing mice, hemorrhagic necrosis of the tumor was observed within 48 hours, and a superior antitumor effect compared to LPS alone was noted in terms of tumor size and weight.

Animals↗
PubMed1982

Postirradiation sarcoma (malignant fibrous histiocytoma) in the inguinal region.

A female patient who died of apparent postirradiation sarcoma at the age of 39 was reported. Following a traffic accident, she developed squamous cell carcinoma at the injured right heel 20 years later, and also metastasis to both inguinal and popliteal lymph nodes. During the period from September 1966 to May 1968, she had received Co60 irradiation to the right inguinal and para-aortic areas, 9,600 and 6,600 Roentgen, respectively. Ten years later, she manifested a huge tumor in the inguinal region which extended further to the retroperitoneum; light and electron microscopic examinations proved to be a malignant fibrous histiocytoma. She died of massive pulmonary metastasis two years later. Histological differentiation of the tumor and relationship between irradiation and sarcoma induction were briefly discussed, and the necessity of reevalution of soft part sarcomas was emphasized.

Abdominal Neoplasms↗
PubMed1982

Bile acid absorption kinetics in Crohn's disease on elemental diet after oral administration of a stable-isotope tracer with chenodeoxycholic-11, 12-d2 acid.

A non-radioactive tracer, deuterium, incorporated in chenodeoxycholic acid, was used to study bile acid absorption kinetics employing gas chromatography-mass fragmentography for its analysis. Eight patients with Crohn's disease and four control volunteers were administered chenodeoxycholic-11, 12-d2 acid. In order to obtain constant dietary conditions, they were fed by an elemental diet during the study. There were significant reductions of the biological half-life of chenodeoxycholic-11, 12-d2 acid, the pool size of chenodeoxycholic acid, and the total bile acid pool size in patients with Crohn's disease as compared with those in normal subjects. There was a marked increase in the relative concentration of ursodeoxycholic acid with a concomitant decrease of deoxycholic acid in patients with Crohn's disease, although such differences did not reach statistical significance. The present study confirms that there are some impairments of enterohepatic circulation of bile acids in patients with Crohn's disease.

Adolescent↗
PubMed1982

[Effect of immunochemotherapy on the cases of advanced gastric cancer stage III].

This study was conducted in patients with stage III gastric cancer who were admitted and gastrectomized in our Department of Surgery during July 1971 to March 1980. The control group consisted of 32 patients who were treated with mitomycin C and FT -207 during the first half of the period and the levamisole (LMS) group of 32 patients who were treated with the same regimen plus LMS during the latter half of the period. No significant statistical difference in their back ground factors was found. The LMS group was treated with 150 mg/day of LMS for 3 consecutive days every other week starting 3 days before operation. The follow-up study up to 30 postoperative months indicated an enhancing effect of LMS on the survival rate in patients with gastric cancer stage III undergoing curative resection. LMS proved to be effective on inhibition of the tumor growth when the tumor sizes ranged 4.0 to 7.9 cm, and the metastases were limited within the regional lymph node.

Drug Therapy, Combination↗
PubMed1982

[Antitumor effect of polysaccharide lentinan on C3H/He mice bearing MH134 ascites hepatoma].

1. Lentinan inhibited the proliferation of MH 134 ascites hepatoma transplanted subcutaneously into C3H/He mice, but its most favorite effect appeared when 1mg-2mg/Kg of lentinan was administered for 10 consecutive days from the eighth day after tumor transplantation, yielding a tumor proliferation-inhibition rate of 33% in the average tumor diameter. 2. In studying the average survival days by the chemotherapy of mitomycin C (MMC), 5-fluorouracil (5-FU), and cytosine arabinoside (Ara-C) in combination with lentinan, when both of these substances were administered concurrently in the second week of the tumor transplantation, average survival time was 29.2 days as compared to 20.5 days in the untreated group, 25.1 days in the group administered lentinan alone, and 22.0 days in the group receiving chemotherapy alone. 3. When the antitumor activity of lentinan was studied by the change in the macrophage migration inhibition activity (MI), it was found that in the untreated group MI activity disappeared on the 14th day after tumor transplantation, while in the group treated with lentinan observation of a positive activity in the spleen cells suggested a restorative action of lentinan of the immunity suppression accompanying the tumor growth.

Animals↗