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Biomedical subjects

H Meyer

Publications and source records attributed to H Meyer.

At least 685 records · Page 38Linked to original sources
PubMedDate not supplied

Coexpression of alpha and beta myosin heavy-chain isoforms in atria of neonates and infants with congenital heart disease.

The relative amounts of cardiac myosin heavy-chain isoforms (MyHC) in right atrial tissue (RA) of 16 neonates and children suffering from congenital heart disease have been investigated. Quantification of MyHC was based on one-dimensional gel electrophoresis and on histometrical evaluation of cyro-sections stained with monoclonal antibodies against alpha- and beta-MyHC. The mean right atrial pressures ranged from 2 to 14 Hg. The RA load was normal in eight patients (5.1 +/- 1.3 mm Hg) and overloaded in eight cases (10 +/- 2.5 mm Hg). The arterial oxygen saturation was normal in 12 and ranged between 85% and 89% in four cases. In all patients a large proportion of atrial myocytes coexpressed alpha- and beta-MyHC. However, in the cases with pressure overloaded RA the amount of beta-MyHC was found to be 1.6 times higher than in the cases with normal pressure. This indicates an adaptational response to overload, as was previously described for the adult human heart. In light of this finding, it seems important to conserve as much as possible of the trained right atrial wall during a Fontan type of operation.

Adolescent↗
PubMedDate not supplied

[Kinematics of various joint mechanisms for the prosthetic substitution of the knee joint following knee exarticulation].

In the past, long amputation stumps of the thigh after knee disarticulation were difficult to fit with a knee prosthesis. Apart from other difficulties, one essential problem was caused by the fact that in preservation of the femoral length there was little or even no space to assemble a knee prosthesis at the level of the axis of the natural knee joint, that is to say at a position somewhere within the femoral condyles. In the meantime the number of knee disarticulations has increased and thus substituted the conventional above knee amputation. Consequently some new, partly polycentric knee joint mechanisms have been designed for the prosthetic fitting of knee disarticulation stumps as well as for long amputation stumps of the thigh. These mechanisms try to cope with the space problem in different ways and, moreover, some of them can also produce a moving centre of rotation at joint flexion similar to the natural knee joint. The motion pattern in current knee joint mechanisms is investigated by graphical construction of their centrodes and it is compared to the motion pattern of the natural knee joint.

Artificial Limbs↗