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Biomedical subjects

H Matthys

Publications and source records attributed to H Matthys.

At least 235 records · Page 13Linked to original sources
PubMed1979

Inhalative provocation test. When is it positive?

A range for the airway resistance (R), reference resistance (Rref), quotient (R/Rref) measured by whole body plethysmography is given for unspecific inhalative provocation in asthmatic patients. 1. In patients with an initial R/Rref value less than 2 (R about 0,6 kPa/l/s) the non allergic reaction did not exceed an R/Rref quotient of 2,7. 2. Those patients with an initial R/Rref quotient greater than 2 but less than 5 reached an R/Rref value of 8.5 after non allergic provocation, which equals an R of about 1,75 kPa/l/s. It is recommended to provoke only those patients in whom the initial R/Rref quotient is in the beginning smaller than 2; because it is otherwise difficult to separate allergic from non allergic reactions and the necessary allergen induced bronchospasm might be harmful. Reference values for specific airway resistance have the advantage that we do not need a panting manouvre against a closed shutter which is often difficult to achieve especially with children during an asthmatic attack.

Airway Resistance↗
PubMed1977

[Comparison of the antitussive effect of two different drugs regarding frequency and strength of cough attacks (author's transl)].

The antitussive effect of two different drugs A (Codeine, Phenyltoloxamine) and B (Dihydrocodeine, Remedacen) was compared in a double blind clinical trial by measuring the frequency and strength of cough attacks for 7 hours. The cough attacks were measured by a pressure-monitoring device which was externally fastened to the throat. Drug B suppressed the strenght and frequency for at least 9 hours after application while the effectiveness of drug A lasted only for about 6 hours after application. In any case the respiratory drive was unaffected.

Adult↗
PubMed1977

[A multi-centre study of reproterol, a bronchodilator (author's transl)].

Reproterol (Bronchospasmin), a monomolecular combination of catecholamine and theophylline, was tested in 81 patients with bronchial asthma or chronic obstructive bronchitis after a single oral dose, and compared with orciprenaline by intra-individual cross-over test. Five pulmonary-function laboratories cooperated in the study. A statistically significant bronchodilator effect, as measured by airway resistance and volume-corrected resistance, was obtained with 20 mg reproterol, having its onset after about 30 minutes, reaching its peak after 2-3 hours, and lasting for at least 4 hours. Comparing the area under the time-effect curves, the total effect was greater than that after 20 mg orciprenaline, pO2 rose higher after reproterol than after orciprenaline, but only by a few mm Hg. Neither heart rate nor blood pressure changed significantly after reproterol.

Airway Resistance↗
PubMed1977

Problems in evaluating the effect of secretolytic agents on the mucociliary system by means of radioactive particles.

In a double-blind cross-over study the effect of two secretolytic agents on the mucociliary clearance was tested in 8 patients with mild chronic obstructive bronchitis. Clearance was assessed from the removal rate of previously inhaled sulfur colloid particles, tagged with 99Tcm. For the interpreatation of the results, obtained by this method, it is essential to take into account the pattern of particle deposition. For example there was a faster clearance under placebo compared to the secretolytic drugs because of a more central deposition. To overcome this problem different approaches were therefore tested. The following constellations proved to be useful in assessing the effect of secretolytic drugs: (1) change in deposition patter; (2) clearance rate, if no change in deposition takes place; (3) clearance rate from a peripheral area of the lung. An attempt to apply a simple three compartment model proved to be unpracticable probably becuase of the complexity of the mechanism involved. One of these mechanisms could be a reversal in mucus transport, observed at least in one patient, a finding which might be of pathophysiological relevance.

Airway Obstruction↗
PubMed1976

[Cardiopulmonary adaptation to acute hypoxia (author's transl)].

The most important adaptive mechanism to acute hypoxia is alveolar hyperventilation which improves the oxygen uptake in the lung. The delivery of oxygen to the particular organs is regulated according to their vital function. An essential adaptive mechanism can not be observed above an inspiratory O2 partial pressure of 100 mm mercury, corresponding to an altitude of about 3000 m in normals. In contrast, in patients with cardio-pulmonary disturbances adaptive mechanisms take place at far lower altitudes. Especially in patients with arterial hypoxemia, pulmonary hypertension and occlusive vascular disease moderate hypoxia may lead to decompensation of an a priori unstable equilibirum.

Acclimatization↗
PubMed1976

[Functional scintigraphic radiospirometry. First clinical results in patients with lung diseases].

First clinical results of patients with diseases of the lungs. The previous experiences on patients with diseases of the lungs reveal that the regional function diagnostics of the lungs may be extended and improved by functional scintigraphic radiospirometry. Because of the determination of regional lung volumes restrictive lung diseases can be differentiated and analysed more exactly than it has been possible before by the examinations of perfusion and ventilation alone. A further advance of the determination of lung volume is that the question of functional operability can be cleared up exactly. In our opinion the routine use of the functional scintigraphic radiospirometry is justified. A contraindication for this kind of examination should only be pregnancy.

Adult↗