Clinical studies of Pneumocystis carinii and relationships to AIDS.
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Biomedical subjects
Publications and source records attributed to H Masur.
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To assess possible side effects of transcranial magnetic stimulation on the release of anterior pituitary gland hormones three different examinations on 10 males were performed following a standardized protocol. Plasma levels of prolactin, FSH, LH, hGH and cortisol were determined before and after stimulation. Cortical stimulation had no specific influence on the plasma levels of the hormones examined.
Corticomotoneuronal latencies after non-invasive stimulation of the motor cortex were studied in two patients with adrenomyeloneuropathy (AMN), in one patient with adrenoleukodystrophy (ALD), in two obligate heterozygotes, and in three clinically not affected sisters of the patients with AMN. Corticomotoneuronal latencies were prolonged in the patients as well as in obligate female carriers, but normal in the clinically and biochemically not affected relatives. The noninvasive cortex stimulation was found to be a sensitive method to detect clinical and subclinical deficits in patients and heterozygous carriers.
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To determine a possible involvement of the autonomic nervous system in amyotrophic lateral sclerosis (ALS), measurement of the sympathetic skin response (SSR) was performed in 15 patients with definite ALS. Findings were compared with those in 20 normal controls. In ALS patients the mean SSR latencies recorded from the palms and soles were both significantly prolonged (p < 0.05) and the amplitudes were reduced as compared with normal persons. In 5 patients, SSR potentials were completely lacking in one or even more extremities. Our data strongly suggest subclinical involvement of the autonomic nervous system in ALS as assessed by the SSR response. In our patients the extent of autonomic dysfunction was not related to the stage or the duration of disease.
In order to determine the function of the autonomic nervous system in syringomyelia, the sympathetic skin response (SSR) was performed in 13 patients with syringomyelia and 20 healthy controls. SSR was recorded from both palms and soles. In patients with syringomyelia, we found absent responses, prolonged latencies and reduced amplitudes. SSRs could be recorded in 15 out of the examined 26 upper extremities. The latencies were prolonged in 12 of these cases. In the lower limbs, 11 SSRs could be obtained. In 4 of these cases the latencies were prolonged. The SSR latencies recorded from the palms and soles were both significantly prolonged (p < 0.05) and the amplitudes were reduced (p < 0.05) as compared to normal persons. Our data strongly suggest involvement of the autonomic nervous system in syringomyelia as assessed by the SSR response (in upper and lower extremities). In our patients, the extent of autonomic dysfunction was not related to the stage or the duration of disease.
Somatosensory evoked potentials (SEPs) were elicited by magnetic stimulation of the tibial nerve, gastrocnemic muscle and by stimulation over the spinous processes of lumbar vertebra 5 (L 5), thoracic vertebra 9 (Th 9) and cervical vertebra 7 (C 7). The first SEP-positivity (P1-latency) was measured in a group of 20 controls and in another group of 18 patients with syringomyelia. The P1-latencies of the latter group following the stimulations over Th 9 and C 7 were significantly longer than those of the controls. Furthermore a correlation between electrophysiological findings and clinical data of the patients could be proven. Thus the method emerged as an appropriate tool for the investigation of the central part of the sensory system and for the diagnosis of spinal abnormalities.
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