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Biomedical subjects

H Martin

Publications and source records attributed to H Martin.

At least 289 records · Page 16Linked to original sources

[Cholesteatoma of the petrous bone with major expansion. Apropos of 17 cases].

Cholesteatomas with major extension correspond to lesions invading beyond the classical limits of middle ear affections. Pathogenicity, and clinical and therapeutic aspects of the disorder are discussed in relation to 17 cases where the affection appeared to be secondary to initial otitic lesions. The diagnostic difficulty in patients with open tympanic membranes is the evaluation of the degree of extension of the lesion, while it has to be considered in patients with closed membranes, particularly in the presence of facial paralysis and internal ear deafness. Radiographic examinations, even when of high quality, may fail to detect cholesteatomas with major extension, and these may be a surprising finding on operation. Treatment is uniquely surgical and requires experience in otoneurosurgical techniques. Total excision is essential in order to avoid rare but serious complications of the affection.

Bone Diseases↗

[Arsin (AsH3) poisoning: hemolysis and kidney failure].

A 46-year-old chemist inadvertently inhaled arsine (AsH3) at work. After several hours abdominal cramps, haemolytic jaundice and massive haemoglobinuria developed. There was transitory hypoxaemia and compensated renal insufficiency. After forced diuresis and transfusions the patient slowly recovered. The only residual defect is arterial hypertension which requires treatment.

Acute Kidney Injury↗

[Necrotizing sialometaplasia. A rare diagnostic pitfall].

Concerning an observation of necrotizing sialometaplasia the authors make a literary survey, paying particular attention to the clinical and anatomopathological descriptions of the lesion. They insist on its deceptive aspect which led in some cases to important quite useless exeresis, since the lesion heals spontaneously. At last the different etiopathogenical hypothesis are reported.

Adult↗

[Results of cerebral computer tomography in the diagnosis of tumors of the sella region].

Computer tomography (CT) is an important aid to the diagnosis of sella tumours because it images the tumour directly and delineates it from the healthy tissues. The tumour type can be identified to a certain extent, but angiography is necessary to distinguish tumours from aneurysms. The study is based on 140 surgical and histological examinations, the results of which were compared wit those obtained by CT. Suprasellar inflammations could always be identified by CT. Although intrasellar tumours may be identifiable by CT if full use is made of the potential of the equipment, negative CT results do not necessarily mean that there is no tumour. The diagnostic validity of the method is restricted by the absence of "standards", against which the variable images of intrasellar structures can be judged, and the restricted resolution of CT.

Adenoma↗

[Finally an effective treatment of facial hemispasm?].

In the absence of a known or generally admitted etiopathogeneicity, and as a result of failure of medical treatment for facial hemispasm, various surgical procedures have been proposed to alleviate this affection. Two types of operation can be distinguished: muscle resection and facial nerve surgery. The latter includes alcohol injection, combining of the 2nd part of the nerve, neurotomy, or neurectomy of the main or distal portions. However, recurrence is very frequent. Two cases were treated by evulsion of the suborbital nerve with marked success, all the above-mentioned procedures having been employed in one of these cases. Though it is too early to speak of recovery, there was no associated motor deficiency, particularly in the regions of the eye and labial commissure. These findings evoke possible relationships between facial and trigeminal nerves, a peripheral motor stimulus-response process providing an explanation for the hemispasm and its cure after evulsion of the suborbital nerve.

Adult↗

Automated image analysis of glioblastomas and other gliomas.

Tumours of the neuroglia, 172 in all (50 glioblastomas, 65 fibrillar and gemistocytic astrocytomas, 26 pilocytic astrocytomas and 31 oligodendrogliomas), were studied by automated microscopic picture analysis. Thirteen morphometric and densitometric parameters of the tumour cell nuclei as well as two mitotic parameters were determined on 4 micrometers thick Feulgen slide preparations. The correlation of the results with subjectively established grade of malignancy was examined. A close correlation was found between almost all morphometric-densitometric nuclear parameters and the morphologically established behaviour of the tumours under study. Based on these results both the method of automated microscopic picture analysis and the selected parameters have been assessed as efficient for the evaluation of the behaviour of glial tumours. The results are readily reproducible and can be obtained without requiring much time. An other advantage of this method is the use of histological preparations, which allows a comparison of the overall structure of the tumour as well as a pinpointed examination of those regions that are representative of the tumour. Subjective grading of glial tumours has been greatly objective by automation.

Adolescent↗