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Biomedical subjects

H Markowitz

Publications and source records attributed to H Markowitz.

46 records · Page 3Linked to original sources
PubMed1967

Antibodies in histoplasmosis.

Production of precipitating and complement-fixing antibody in rabbits and other animals was induced by immunization with live yeast-phase cells of Histoplasma capsulatum. Results of studies of polysaccharide antigens from three strains of H. capsulatum, by quantitative complement-fixation with human and rabbit antisera, strongly suggest the presence of type specificity. The variations of titer during 11 weeks in one patient with histoplasmosis and the variations of titer among a group of patients with histoplasmosis were studied by use of quantitative complement-fixation tests.

Animals↗
PubMedDate not supplied

Frequency and significance of antibody to double-stranded DNA in chronic active hepatitis.

To assess the frequency and significance of immunoglobulin G antibody to double-stranded DNA in chronic active hepatitis, 99 patients with severe disease were tested for the antibody by an enzyme-linked immunosorbent assay of established sensitivity and specificity. Antibody was detected in 56 patients (57%) and occurred with similar frequency in patients with autoimmune (64%), idiopathic (46%) and type B (43%) disease. The mean serum level of antibody was higher in autoimmune disease but it was not significantly different from that in the other diagnostic categories. Patients with and without the antibody could not be distinguished by clinical, laboratory or histologic findings. Responses to corticosteroid therapy and mortality were unrelated to antibody status. In five patients, the antibody disappeared after corticosteroid treatment and induction of histologic remission. We conclude that immunoglobulin G antibody to double-stranded DNA is frequently present in patients with severe chronic active hepatitis. Patients with autoimmune disease may have higher antibody levels than others, but the presence of antibody does not connote a disease of specific etiology, unique presentation or different behavior. The prevalence of the finding and its disappearance after corticosteroid therapy suggest that it is a nonspecific manifestation of inflammatory activity.

Adrenal Cortex Hormones↗
PubMedDate not supplied

Pseudotumor artifact of the dorsum sella in CT scanning.

Misinterpretation of CT scans in the skull base can result from artifacts due to abrupt density variations of anatomical structure. In this report a wide dorsum sella with low attenuation medullary cavity was initially mistaken on axial scans for an enhancing suprasellar mass. The correct diagnosis was made with follow-up scans based upon thinner cuts, slice angulation negative to the baseline, and reconstructed coronal and sagittal images.

Adolescent↗