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Biomedical subjects

H Loeb

Publications and source records attributed to H Loeb.

At least 37 records · Page 2Linked to original sources
PubMed1986

Lymphocytic meningoradiculitis (Garin-Bujadoux Bannwarth): from syndrome to disease?

In two children with lymphocytic meningoradiculitis (Bannwarth's syndrome), IgG and IgM antibodies to Borrelia burgdorferi were demonstrated. Clinical and laboratory parameters of the syndrome are described and recent bacteriological and serological findings that link the syndrome to the American Lyme disease are discussed, as well as the effects of antibiotic treatment.

Animals↗
PubMed1982

[Glycosylated hemoglobin and clinical evaluation of the degree of diabetes control. Relation to blood sugar, blood cholesterol, blood triglycerides, and the duration of diabetes and retinopathy. Study of 85 diabetic children and adolescents].

The measurement of HbA1 gives an "objective" estimate of the degree of metabolic control of diabetes during the erythrocyte lifespan. 333 assays in 85 young diabetics aged three to twenty-three years showed a mean HbA1 of 10.9 +/- 2.6% (controls: 7.4 +/- 1.4%). HbA1 levels parallel the clinical evaluation of the degree of control. HbA1 concentrations are correlated with the duration of diabetes (r = 0.26; p less than 0.001), triglyceridemia (r = 0.22; p less than 0.001), cholesterolemia (r = 0.26; p less than 0.001) and glycemia (r = 0.50; p less than 0.001). The HbA1 glycemia correlation grows stronger as glycemia increases. This probably reflects the existence of a labile form of HbA1. HbA1 concentrations measured repeatedly over one year were not significantly different in diabetics with and without retinopathy, probably because the study period was too short. Measurement of HbA1 is also of value in diagnosing non-compliance.

Adolescent↗
PubMed1982

Effect of short-term infusion of sodium nitroprusside on mortality rate in acute myocardial infarction complicated by left ventricular failure: results of a Veterans Administration cooperative study.

Eight hundred twelve men with presumed acute myocardial infarction and left ventricular filling pressure of at least 12 mm Hg participated in a randomized double-blind placebo-controlled trial to assess the efficacy of a 48-hour infusion of sodium nitroprusside. The mortality rates at 21 days (10.4 per cent in the placebo group and 11.5 per cent in the nitroprusside group) and at 13 weeks (19.0 per cent and 17.0 per cent, respectively) were not significantly affected by treatment. The efficacy of nitroprusside was related to the time of treatment: the drug had a deleterious effect in patients whose infusions were started within nine hours of the onset of pain (mortality at 13 weeks, 24.2 per cent vs. 12.7 per cent; P = 0.025) and a beneficial effect in those whose infusions were begun later (mortality at 13 weeks, 14.4 per cent vs. 22.3 per cent; P = 0.04). Nitroprusside should probably not be used routinely in patients with high left ventricular filling pressures after acute myocardial infarction. However, the results in the patients given late treatment suggest that those with persistent pump failure might receive sustained benefit from short-term nitroprusside therapy.

Aged↗
PubMed1982

[Residual insulin secretion in juvenile diabetes. Relationships with duration of diabetes, metabolic control and retinopathy (author's transl)].

This study concerned 74 diabetic children and adolescents, ages ranging from 3 to 21 years. Duration of the disease ranged from 1 month to 15 years. Blood samples were taken during a 12 month period of observation. 292 immunoreactive C-peptide (CPR) evaluations showed a residual endogeneous secretion of insulin in 57% of cases. CPR and duration of diabetes were negatively correlated (r = -0.35; p less than 0.01); however, even 5 years after onset of the disease, a residual beta-cell activity could be observed. CPR was not related with blood glucose, triglyceride, cholesterol or glycosylated hemoglobin levels. On the other hand, CPR was statistically higher in patients whose diabetes had been well-controlled from the onset of the disease, according to clinical criteria, and in those who did not present with retinopathy: however they were also the patients with the shortest duration of disease.

Adolescent↗
PubMed1981

Management of endobronchial hemorrhage during cardiopulmonary bypass.

Massive endobronchial bleeding during cardiopulmonary bypass was encountered in one patient following pulmonary embolectomy and in another following an elective aorta-coronary bypass procedure. Successful management of this complication necessitates control of ventilation by prolonging cardiopulmonary bypass to ensure adequate oxygenation, suctioning the airway to clear blood from the major tracheobronchial tree, and immediately instituting 20 cm H2O of positive end-expiratory pressure (PEEP) to control endobronchial bleeding.

Bronchial Diseases↗
PubMed1979

Leakage of fluorescein: first sign of juvenile diabetic retinopathy. Role of diabetic control and of duration of diabetes.

In order to ascertain the first vascular lesions responsible for juvenile diabetic retinopathy, 408 fluorescein angiographies were performed in 114 diabetic children and adolescents whose diabetes became clinically apparent before the age of 14 years. Compared with regular ophthalmoscopy, fluorescein angiography doubles the frequency of the diagnosis of incipient retinopathy. In addition to the classical diabetic lesions, fluorescein leakages are demonstrated in 50% of diabetic eyes with initial retinopathy. They probably reflect early changes in capillary permeability. They appear often before microaneurysms. Duration of diabetes as well as insufficient and poor metabolic control considerably increase the frequency of retinopathy.

Adolescent↗
PubMed1979

Mauriac syndrome: three cases with retinal angiofluorescein study.

Three children with features of the Mauriac syndrome have been studied. Ocular complications, mainly characterized by increased capillary permeability have been demonstrated by fluorescein angiography. A decreased proximal tubular beta 2-microglobulin reabsorption has been found in one patient, and in another one, there was a slowed sensory nerve condition velocity. A liver biopsy, performed in one patient, has shown numerous fat filled cells and intralysosomal lipofuscin storage. No hormonal disturbance, which could explain the growth reardation, has been found. Bad metabolic control of diabetes could be responsible for all the anomalies of Mauriac syndrome.

Adolescent↗
PubMed1977

[Diagnosis of juvenile diabetic retinopathy using fluorescein angiography. Description of initial lesions].

In order to ascertain the first vascular lesions responsible for infantile diabetic retinopathy, 300 angiofluorographies were performed in 87 children and adolescents whose diabetes became clinically apparent before the age of 14. Compared with normal ophtalmoscopy, the angiofluorography enabled to double the frequency of the diagnosis of incipient retinopathy. In addition to the classical diabetic lesions, the authors describe modifications of vascular permeability noted by leakage of fluorescein and observed in 75% of initial retinopathies. These leakages must be considered to be the first lesions of infantile diabetic retinopathy. They appear before microaneurysms: they seem to be reversible. Highly significant correlation between degree of control, duration of diabetes and frequency of retinopathy were demonstrated.

Adolescent↗
PubMed1977

Mannosidosis.

Explore the source record for details and available documents.

Carbohydrate Metabolism, Inborn Errors↗
PubMed1977

Reversal of advanced left ventricular dysfunction following aortic valve replacement for aortic stenosis.

A series of 12 consecutive patients who underwent aortic valve replacement (AVR) for aortic stenosis complicated by severe left ventricular dysfunction was reviewed. Ventricular dysfunction was reflected by pulmonary congestion, edema, renal and hepatic dysfunction, and by severely depressed ejection fractions (mean, 13%; range equal to 0-20%). Aortic valve replacement was accompanied by mitral commissurotomy in 1 patient and aortocoronary bypass in 5. Three of 5 patients with greater than 50% coronary obstruction died without reversal of heart failure, and 1 of the 5 died after a stroke. The 1 survivor of this group has done well. All 7 patients with minimal or no coronary disease survived operation and are now in New York Heart Association Class I or II. Postoperative catheterization (2 to 12 months) in 6 patients showed improved cardiac index and filling pressures. Left ventricular diastolic volume fell from 159 to 82 ml/m2, and ejection fraction rose from 13 to 45%. We conclude that left ventricular dysfunction owing to aortic stenosis alone is reversible and that AVR results in great clinical improvement. When coronary disease is present, survival may be accompanied by great improvement but the operative mortality is much higher.

Aged↗