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Biomedical subjects

H Lange

Publications and source records attributed to H Lange.

At least 199 records · Page 11Linked to original sources
PubMed1979

[Renal blood flow, diuresis and isotope nephrogram in experimental stenosis of the renal artery (author's transl)].

After experimental stenosis of the renal artery of the dog, the isotope nephrogram shows a prolongation of the transit-time, when the renal blood flow is reduced to 40--70%. This finding was most significant in low diuresis (0,05--0,2 ml/min), sporadic in moderate diuresis (0,2--2,0 ml/min), no longer demonstrable in forced diuresis (greater than 2,0 ml/min). The diuretic effect of X-ray contrast medium (70% Na-Meglumin-Jotalamat, 0,5 ml/kg i.v.) normalizes a pathologic ING in low diuresis.

Animals↗
PubMed1979

[The crescent sign in childhood urography].

The crescent sign is a rare roentgenological symptom in excretory urography of infantile hydronephrosis. The orign is a presence of contrast material in the collecting renal tubule of the atrophic renal parenchyma. That is displaced at the renal circumference. The disappearance of the crescent sign represents the prognostic for the reparative potence of the renal parenchyma after the therapy of the obstructive uropathy in two own case.

Adolescent↗
PubMed1978

[Investigations in the streaming blood of the alert animal and man. III. Postprandial and therapeutically induced changes of electrolyte concentration and hematocrit in man during hemodialysis (author's transl)].

Arterial haematocrit and blood electrolyte concentrations are measured continuously by conductometry in three hemodialysis patients. Haematocrit elevation during meals, particularly when rich in carbohydrates, indicate fluid losses into the gut. Simultaneous biphasic responses in electrolyte concentration indicate osmotic and diffusional shifts of water and electrolytes. Similarly, blood volume and electrolyte concentration changes can be followed during and after intravenous infusion of colloid and crystalloid solutions. The quantitative aspects of such measurements are discussed.

Adult↗
PubMed1977

Temporo-spatial pattern of subcortical spike activity in kindling epilepsy. A statistical approach.

Recording electrodes were implanted stereotaxically in limbic and thalamic structures and the mesencephalic reticular formation in twelve cats. The animals were submitted to daily stimulation of the left amygdaloid nucleus following the technique for the kindling procedure, always combined with 5 h 30 min post-stimulation monitoring. After about 18 days, generalized convulsive activity was established. The following results concerning the quantitative evolution of spontaneously occurring interictal spikes were obtained. Amygdaloid nuclei, the hippocampus and the thalamic nucleus ventralis lateralis (VL) demonstrated an increase of discharge activity during the kindling procedure, following by a significant decrease after convulsions had been elicited. Thalamic nucleus centrum medianum (CM) was the only recording site investigated where the amount of interictal discharge increased and remained at a high level even after generalized convulsions had been established. Fourier analysis of slow oscillations in discharge generation yielded two main types of significant periodicity. A 165 min oscillation could be detected in all structures tested except reticular formation, which developed a 110 min cycle shared only with the thalamic CM. Significant correlations in spike activity were obtained from various structures. Stimulated amygdala seemed to have alternating relations with thalamic CM and VL, whereas stimultaneous oscillations excisted between MRF and CM. The occurrence of high voltage spikes in both contralateral and ipsilateral amygdalae was shown to be significantly correlated.

Action Potentials↗
PubMed1977

[Antibiotics resistance of staphylococci in skin diseases].

Cutaneous infection due to bacteria are predominantly caused by staphylococci. The sensitivity of 1036 staphylococcal strains towards various topical and systemical antibiotics was investigated over a period of three years (1973-1975). Comparing the present results with results from previous investigations revealed that staphylococcal sensitivity towards common antibiotic drugs remained nearly unchanged. A comparatively high proportion of strains has acquired resistance against multiple antibiotics. The importance of routinely determining bacterial sensitivity in antibiotic therapy is emphasized.

Anti-Bacterial Agents↗
PubMed1976

Pharmacokinetics of sisomicin in patients with normal and impaired renal function; its efficacy in urinary tract infection.

Serum concentration, biological half-life, distribution space and serum clearance of sisomicin, a new aminoglycoside antibiotic, have been studied in twenty-three patients in comparison with the pharmacokinetics of 125I-labelled iothalamate, a compound only filtered by the kidney. 10 patients had normal or borderline abnormal serum creatinine (less than 1,5 mg/100 ml), 8 had various degrees of renal insufficiency (serum creatinine 1.7-9.6 mg/100 ml) and 6 were being treated by intermittent haemodialysis. After intravenous injection of sisomicin 1 mg/kg body weight in patients with normal or borderline renal function its half-life was 3.5 h, very similar to that of iothalamate, 3.2 h. The mean distribution space was 20.1% per cent of body weight; iothalamate, 23.7%. In patients with renal insufficiency there was a positive correlation between serum creatinine level and the half-life of sisomicin, and an even stronger correlation between the clearances of iothalamate and sisomicin. In patients dependent on haemodialysis, the mean serum half-life between dialysis was 40 h, compared to approximately 100 hours for iothalamate, which implies additional extrarenal clearance or tubular secretion of sisomicin. The results of pharmacokinetic studies indicated that a regime of sisomicin 1 mg/kg every 8 to 12 hours in patients with normal renal function would result in serum and urine levels sufficiently high to treat most urinary tract infections. In patients with impaired renal function the dosage interval should be increased according to the serum creatinine level, and in patients dependent on haemodialysis one standard dose at the end of each dialysis period should suffice. 9 patients with a chronic urinary tract infection severely complicated by an underlying disease were treated according to this dosage regimen with a satisfactory bacteriological and clinical result. No adverse reactions or signs of accumulation were observed.

Adult↗