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Biomedical subjects

H Laccourreye

Publications and source records attributed to H Laccourreye.

At least 127 records · Page 7Linked to original sources

[Use of the CO2 laser in the emergency treatment of dyspnea in laryngeal cancer].

Occlusion of the larynx of neoplastic origin was treated by CO2 laser in seven patients between Marc 1982 and April 1983. Temporary tracheotomy was avoided in all 7 cases but treatment had to be repeated in two patients. Specific anesthetic techniques necessary when using the laser in hypercapneic patients are described, and the advantages, limitations and complications of this therapy are discussed.

Carcinoma, Squamous Cell↗

[Comparative study of 2 chemotherapy induction protocols. Cisplatinum-methotrexate-bleomycin and oncovin-methotrexate-bleomycin].

A prospective randomized study was conducted in 77 patients with stages III and IV epidermoid carcinomas of the buccal cavity, oropharynx, and pharyngolaryngeal regions to compare effects of two induction chemotherapy regimens: cisplatinum, methotrexate, bleomycin, and oncovin, methotrexate, bleomycin. Tumoral response and complications were analyzed as a function of the regimen, the tumoral site, and the stage. Chemotherapy including cisplatinum provided a tumoral response in 58.8 p.cent of stage III pharyngolaryngeal epitheliomas as against 38.4 p.cent with oncovin, methotrexate, bleomycin, but with a higher frequency of complications.

Antineoplastic Combined Chemotherapy Protocols↗

[Value of computed tomography in tumors of the pharyngolarynx].

A study was conducted of 27 case-reports to assess the value of computed tomography for investigation of pharyngolaryngeal cancer spread. Analysis was by comparison of clinical, endoscopic, conventional radiologic, computed tomography, and definitive operative specimen histologic findings. Certain laryngeal structures were studied more particularly: the anterior commissure, the pre-epiglottic spaces, the subglottic region, and the thyroid cartilage. Findings demonstrated that the CT Scan is of no value for the study of the anterior commissure and the pre-epiglottic spaces, but is of major interest for detection of subclinical lesions of the subglottic region and thyroid cartilage.

Carcinoma, Squamous Cell↗

[Nystagmus and benign paroxysmal vertigo (author's transl)].

Audio-impedence, vestibular, caloric, and electronystagmograph tests were conducted in 22 patients with benign paroxysmal vertigo. The disorder is provoked by certain sudden head movements, a latency period of several seconds occurring between the end of the movement and the onset of vertigo. This markedly differentiates it from other types of vertigo. It is of brief duration and associated with autonomic nervous system signs. Nystagmus, usually rotatory, is provoked by the particular head movement involved or by Hallpike's manoeuver. Results of the majority of tests were normal, occasional slight anomalies being observed after calibrated caloric vetibular test. This benign affection appears to be due to a bilateral, or more frequently unilateral mechanical lesion of the posterior semicircular canal cupula. It runs a extremely variable course, usually not exceeding four months, and is an indication of choice for vestibular reeducation, for which new techniques have been developed.

Electronystagmography↗

[Preliminary results of a preoperative polychemotherapy protocol in carcinomas of the pharyngo-larynx. Oncovin, methotrexate and bleomycin (author's transl)].

213 squamous carcinomas of the pharyngo-larynx (piriform fossa, pharyngo-laryngeal junction and larynx) received preoperative chemotherapy in the form of oncovin, methotrexate and bleomycin (OMB). All the patients then underwent total or partial laryngectomy, associated with lymph node excision of some sort, followed by radiotherapy. A symptomatic improvement after OMB was seen in 21.2% of cases. Overall tumour response regardless of the site was 32%. Tumour response was all the better when lymph nodes were histologically free of disease (38.7% tumour response in N- as against 26.7% in N+). There was no significant difference in 1 year survival rates between those patients in whom there was a tumour response and those in whom tumour size remained the same.

Aged↗

[Simultaneous or successive locations carcinomas of head and neck (author's transl)].

204 simultaneous or successive locations of carcinoma were observed and analysed in a series of 1992 cases of head and neck carcinomas for 15 years (10.24 p. 100). Simultaneous carcinomas appeared electively in single anatomical area: hypopharynx, oropharynx, endolarynx. Successive carcinoma on the other hand are developed in adjacent anatomical sites. An oesophagal location worsens the prognosis; the related facts and rules are analysed for their frequency. An early detection II counselled and their pathogenesis is discussed.

Adult↗

[The role of primary surgery in the treatment of carcinomas of the tonsillar region (author's transl)].

The aim of this study was to identify the role of surgery in the treatment of carcinomas of the tonsillar bed. A retrospective review involved 158 records of patients treated between 1969 and 1979. It emerged that locoregional failures were more frequent after primary radiotherapy than after primary surgery. Only a limited number of patients could be treated and cured by secondary salvage surgery. The high prevalence of locoregional failures after radiotherapy and new techniques for reconstruction after extended resection have led us progressively to adopt an attitude based upon primary surgery in the treatment of carcinomas of the tonsillar bed.

Carcinoma↗

[Tracheotomy in the surgical treatment of carcinomas of the pharyngo-larynx (author's transl)].

The authors studied the local postoperative course and period of hospitalisation after 890 total and partial pharyngo-laryngectomies according to whether the operation was started under general anaesthesia by intubation or after tracheotomy under local anaesthesia. The authors show the improvement in postoperative course as well as the decrease in the period of hospitalisation when intubation was used first.

Anesthesia↗

[Laryngeal and laryngotracheal stenoses. Classification and treatment (author's transl)].

Results of treatment of 63 cases of laryngeal and laryngotracheal stenosis are presented and a classification of these lesions discussed. Two main types are distinguished: simple isolated stenoses (arytenoid, cricoid and tracheal) and compound stenoses (arytenocricoid, tracheocricoid, arytenotracheocricoid, arytenotracheal). Only arytenoid stenoses, those with an arytenoid component, or lesions associated with laryngeal paralysis provoke cord immobility. The arytenoid lesion therefore differentiates stenoses with fixed from those with mobile vocal cords. Treatment mainly involves adequate enlargement of the larynx and crico-tracheal resection, or a combination of these two techniques. Results were positive in 45 cases, insufficient in 5, and nil in 2 cases. Four patients were not seen again, one patient died, and 3 are still being treated. Three patients with successful results still retain a temporary tube while awaiting further therapy for another affection (esophageal stenosis). Results are analysed as a function of the site of the stenosis, the presence or absence of a tracheotomy, the technique employed, and whether previous treatment had been employed. Excluded from this report, which concerns 63 patients with laryngeal or laryngotracheal stenoses treated in the Hôpital Laennec, Paris, were cases of pure tracheal stenosis treated by resection and tracheotracheal or cricotracheal anastomosis, and with healthy cricoids, and synechiae or anterior glottic (or anterior commissural) stenoses. They were either congenital, or iatrogenic following endoscopic surgical procedures in the glottic region. Also excluded were cases of stenosis where surgery was not indicated, as well as two patients with laryngeal stenosis, one due to an amyloid tumor and the other to Launois Bensaudes disease.

Adult↗

[Partial vertical surgery of the larynx : results as a function of anesthesia and the employ of tracheotomy (author's transl)].

Postoperative course and complications were studied as a function of the type of anesthesia, and the employ of a tracheotomy tube and gauze drainage of the laryngeal cavity, following partial vertical surgery on the larynx of 238 patients. Findings demonstrated that a general anesthetic by intubation with total skin closure without tracheotomy and gauze drainage of the laryngeal cavity, reduced the incidence of local infections complications and the duration of hospitalization. Without insisting on the advantages of this type of anesthesia and the value of immediate suturing, the authors note that these simple techniques markedly reduce the hospitalization period at a time when emphasis is being placed on the economic impact of the duration of this period.

Anesthesia↗

[Epitheliomas of the margin of the larynx. Definition, classification and extension (author's transl)].

Studying 213 cases of epithelioma of the laryngeal margin, the authors report on a 3-part study. The first part defines, classifies and specifies the extension of marginal epitheliomas, the second part studies anterior margin epitheliomas and the third, epitheliomas of the lateral margin. This first part shows that the laryngeal margin forms a precise anatomo-clinical entity which must be subdivided into anterior lateral posterior and total margins. The anterior margin consists of the free edge, the supra-hyoid laryngeal side of the epiglottis and, for the authors, the laryngeal side of the epiglottis that belongs, for the UICC, to the oropharynx. The lateral margin consists of the aryteno-epiglottic fold and, for the authors, of the intersection of the three fold that are not mentioned in the UICC or the AJC classifications. The arytenoid cartilage forms the posterior margin. Together, tumors of the anterior margin and the lateral margin make up for 94% of marginal tumors. This first part specifies the macroscopic aspects of marginal epitheliomas with their local and lymphatic extension.

Carcinoma↗

[Epitheliomas of the anterior margin of the larynx. A study of 102 cases (author's transl)].

In this second part, we study 102 cases of epithelioma of the anterior margin of the larynx. The authors insist on the need for bilateral treatment of lymphatic areas on account of their frequent bilateral involvement, jumping from 9% for N0 to 80% for a fixed unilateral enlarged lymph node. Whatever the T stage, the best therapeutic results are provided by total or partial surgery of the lesion combined with surgical treatment of lymphatic areas completed by irradiation.

Carcinoma↗

[Epitheliomas of the lateral margin (author's transl)].

The third part ends the study on epitheliomas of the laryngeal margin and concerns 8 cases of epithelioma of the lateral margin (aryteno-epiglottic fold and intersection of the three folds). The authors emphasize the considerable lymphatic tropism of these tumors. In 58% of these, enlarged lymph nodes were found, 65% of which showed histological involvement. Best results (survival and local sterilisation) are provided by surgery, partial or complete, depending on the T stage, the tumoral site, and combined with lymphadenectomy, completed by irradiation.

Carcinoma↗

[Laryngotracheal stenosis. Indications and results on the basis of 59 cases (author's transl)].

On the basis of 59 cases of laryngotracheal stenosis, the authors summarised their experience in 3 chapters. The first section defines the etiology, therapeutic indications and results obtained according to whether the stenosis was purely laryngeal or laryngotracheal and whether the vocal cords are mobile or immobile. The second part studies the results of procedures of enlargement of the laryngeal cavity (Rethi-Aboulker type). These results are satisfactory in pure laryngeal stenosis, but are often inadequate for stenosis of the crico-tracheal junction or combined laryngeal and tracheal stenosis. The third part defines the technique and indicates the value of crico or thyrocrico-tracheal resection anastomosis procedures in laryngotracheal stenosis. Thus, there is not single form of treatment for laryngotracheal stenosis. On the basis of pre and per-operative assessment, a choice will be made between the Rethi procedure, crico-tracheal resection or combination of the two.

Adult↗

[Lymphadenopathies associated with carcinoma of the larynx (author's transl)].

On the basis of 287 cases of carcinoma of laryngeal origin, treated by total or horizontal sub-glottal laryngectomy, the authors study the prognosis in lymphadenopathies. This prognosis is envisaged in the light of the international nomenclature NO, N1, N2, N3, in relation to the size of the nodes and, finally, in relation to the surgical or radiotherapeutic treatment given to the node areas. The authors emphasise the need for bilateral surgery to the node areas, this procedure being all the more extensive when the lymphadenopathy is larger. On the basis of this size, a choice must be made between radical dissection, extended cellulo-adenectomy (or functional excision).

Humans↗