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Biomedical subjects

H L Reid

Publications and source records attributed to H L Reid.

38 records · Page 3Linked to original sources
PubMedDate not supplied

Plasma and serum viscosity in Nigerian diabetics.

Relative plasma (RPV) and serum (RSV) viscosities were determined in 71 Nigerian diabetics, with and without hypertension, and compared with an age and sex matched normotensive non-diabetic control group. Viscosity was measured by a simple capillary viscometer. RPV and RSV were statistically significantly raised in diabetics compared with controls (p less than 0.001). RPV was 5.03% and RSV was 4.82% higher than non-diabetic values. There was no significant difference in either RPV or RSV due to sex. Also, no relation of RPV or RSV to age, duration of diabetes or type of treatment was identified. Plasma fibrinogen concentration correlated positively and significantly (r = 0.46; p less than 0.001) with RPV. However, whereas a significant rise was observed for total serum protein, albumin (p less than 0.001) and serum globulin concentrations (p less than 0.005), only the gamma-globulin fraction correlated significantly with RSV (r = 0.27; p less than 0.05). RPV was significantly raised in hypertensive diabetics compared with normotensive diabetics (p less than 0.02) but there was no significant difference in RSV of diabetics attributable to hypertension. Our findings show that fibrinogen predominantly contributes to the increased plasma viscosity while the gamma-globulin made the greatest contribution to serum viscosity in Nigerian diabetics. We suggest that abnormally raised plasma and serum viscosities, by contributing to disturbances in normal blood flow and metabolism, may play an essential role in the development of both micro-circulatory disorders and hypertension in some Nigerian diabetics.

Adult↗
PubMedDate not supplied

Reduced erythrocyte deformability and hyperfibrinogenemia in Nigerian diabetics with hemoglobin genotype HbAA.

Erythrocyte deformability (Vrbc) and plasma fibrinogen values were studied in 44 Nigerian diabetics and 41 age-matched controls, some of whom were hypertensives. All had normal hemoglobin genotype (HbAA). Vrbc was significantly reduced in the diabetic patients compared to the control group (p less than 0.005). Similarly, the Vrbc in hypertensive diabetics was significantly reduced below that in both non-hypertensive diabetics (p less than 0.01) and hypertensive controls (p less than 0.01). Plasma fibrinogen concentration was significantly raised in the diabetics compared to controls (p less than 0.01). Although the fibrinogen was higher in the hypertensive diabetics than in diabetics without hypertension the difference was not statistically significant. There was no significant difference between hypertensive controls and hypertensive diabetics even though the latter had a higher mean fibrinogen than controls without hypertension. We conclude that Nigerian diabetics with normal hemoglobin genotype, HbAA, have poorly deformable RBCs and a hyperfibrinogenemic plasma compared to a non-diabetic control group. These findings may have a considerable prognostic significance in terms of the patients' subsequent progress.

Adolescent↗