Search PubMed⌕ Search

Biomedical subjects

H L Chan

Publications and source records attributed to H L Chan.

At least 145 records · Page 8Linked to original sources
PubMed1984

Fixed drug eruptions. A study of 20 occurrences in Singapore.

Twenty occurrences of fixed drug eruptions (FDE) were studied. Of these, 12 were due to tetracyclines and 4 were due to analgesics (3 from pyrazolone derivatives and 1 from acetylsalicylic acid). Sixteen of the patients had less than 10 lesions each. The lips were affected in eight instances, and therefore seem preferentially involved. At presentation, seven patients were unaware of a drug relationship to their condition. A comparison of six reported series (including this one) revealed that the causative drugs varied over the years 1956-1983 as well as by region.

Adult↗
PubMed1983

Bacterial infections of the skin. I: primary and secondary infections.

Bacterial skin infections are important to recognize because we have the means to eradicate almost all of them. Primary skin infections are mainly caused by staphylococci or streptococci. Staphylococci infections present as furuncles and carbuncles, superficial folliculitis, impetigo or rarely the Scalded Skin Syndrome. Streptococcal infections present as impetigo, ecthyma, erysipelas or cellulitis. Corynebacteria causes erythrasma, trichomycosis or pitted keratolysis. Gram-negative primary skin infections, although uncommon, may occur; bacterial cultures are generally necessary for diagnosis. Secondary bacterial infections of pre-existing wounds, burns, dermatitic skin, or retention cysts are common events.

Anti-Bacterial Agents↗
PubMed1983

Bacterial infections of the skin. II: cutaneous clues to systemic infections.

Systemic bacterial infections often produce skin signs which are of help in the elucidation and evaluation of these diseases. This paper reviews some of such cutaneous clues, their occurrence, recognition and value. The following conditions are discussed: bacterial endocarditis, pseudomonas septicaemia, disseminated gonococcal infection, meningococcemia, clostridia infections, leptospirosis and typhoid fever. Bacterial causes of erythema nodosum are also considered.

Bacterial Infections↗
PubMed1978

Transport of fat through jejunal absorptive epithelium in vitro.

The mucosa of excised pieces of jejunum of fasting rats was exposed for 10 min to fresh chyme obtained from other rats which had been digesting either buttered bread or bread alone. The mucosa was then processed for electron microscopy of lipid material. After exposure to fatty chyme, fat globules were scattered throughout the cytoplasm of absorptive epithelial cells, and concentrated in both supranuclear and infranuclear components of the Golgi apparatus. They were also present within lymphatics of the villus. After exposure to both types of chyme, the basal parts of the cells were much elongated through collection of a finely granular deposit of non-lipid material. This collection was probably due to failure of clearance of absorbed material from the cells in the absence of blood flow through the villus.

Animals↗
PubMed1977

Allopurinol associated hypersensitivity reactions: cutaneous and renal manifestations.

Five patients developed fever, "toxaemia", severe skin reactions and eosinophilia, three to six weeks after commencing allopurinol therapy. The presenting feature in these patients was an extensive erythema, progressing to an exfoliative dermatitis, sometimes with oral mucous membrane involvement. One patient developed toxic epidermal necrolysis. The clinical course in two patients was complicated by acute renal failure which necessitated dialysis. The clinical and laboratory features support an acute hypersensitivity mechanism in these allopurinol associated reactions, in agreement with previous studies. Patients with chronic renal failure appear particularly prone to severe, potentially fatal reactions. If these patients need allopurinol, a lower dose than would be normally required should be given.

Acute Kidney Injury↗