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Biomedical subjects

H Kushiro

Publications and source records attributed to H Kushiro.

At least 19 recordsLinked to original sources
PubMed1994

[A surgical case of giant mediastinal teratoma].

A 35-year-old female was admitted with a large abnormal shadow in the left lung field on a chest X-ray. She was examined by chest tomogram, chest CT, MRI and bronchofiberscope. The CT and MRI showed a large tumor mass pressing the left lung and calcified deposits in the central part of the tumor. Bronchofiberscopic findings showed a stenosis of the left main bronchus. The clinical diagnosis was mature teratoma arising from anterior medistinum. She underwent a median sternotomy and the tumor was removed. The size of the resected specimen, filled with sebaceous material, hair and teeth, etc., was 14 x 12 x 10 cm (1,045 g). Histopathological examination of the specimen revealed a mediastinal mature teratoma. She has been well for 16 months postoperatively.

Female↗
PubMed1984

Studies of four Japanese families with hereditary angioneurotic edema: simultaneous activation of plasma protease systems and exogenous triggering stimuli.

Forty-five relatives of 4 families with hereditary angioneurotic edema (HANE) were studied. Twenty-five, including 11 asymptomatic kindreds with the disposition, showed typical changes in complement system compatible with HANE. Follow-up study of HANE patients showed that, even in remission period, complement, coagulation and fibrinolytic systems can be activated. During edema attacks, moderate haemoconcentration and neutrophilia were encountered and kallikrein-kinin system was found to be also activated. Replacement therapy with C 1-inhibitor preparation for an edema attack revealed that clinical improvement paralleled the increase in blood levels of high molecular weight kininogen. Thus, HANE attack is considered to be elicited in kindreds with the hereditary disposition by activation of plasma protease systems, particularly by that of kallikrein-kinin system. On the other hand, exogenous triggers that can initiate activation of the protease systems can be classified into 2, neuro-humoral (sympathetic nerve response) and physico-chemical, categories. Hence, the edema attack of kindreds with the hereditary disposition can at least be modified by the biosynthesis of plasma factors and the individual susceptibility to the liberated catecholamines. These two different reaction processes are considered to be linked by the release of plasminogen activator and/or Hageman factor activating enzyme.

Angioedema↗
PubMed1983

Rapid emergency testing using blood plasma.

A method of blood analysis, using plasma instead of serum, is very valuable in shortening the time for reporting an emergency test by about 50-60%, by eliminating the serum separation step. Good correlation between plasma and serum was obtained for common chemical analyses.

Blood Chemical Analysis↗
PubMed1981

Serological differentiation of strains of group B streptococci by the soft-agar technique.

Soft-agar technique was applied for serological determination of strains of group B streptococci. With representative type strains, their colonial morphology was converted from diffuse- to compact-type growth only by the addition of homologous rabbit anti-serum in the medium and no conversion of colonial morphology was observed by heterologous rabbit antisera. Twenty seven out of 30 fresh isolates obtained from human clinical specimens showed diffuse-type growth in soft-agar medium and were subjected to this examination. Twenty-one strains reacted with a single antiserum, 5 strains showed reactivities to two different antisera although reaction to an antiserum were significantly higher than those of the other antiserum and no reaction was observed with a strain. Twenty single and 5 major serotypes determined by this technique were coincided with those differentiated by Lancefield's precipitin method. From these experimental results, soft-agar technique was regarded being available for serological typing of strains of group B streptococci.

Agar↗
PubMed1980

Comparison of three blood-clotting substances in Staphylococcus aureus strains.

Besides the two well-known blood-clotting substances, coagulase and clumping factor, a third one has been identified from the staphylococci which is a cell surface polysaccharide, is alkali stable, and induces compact-colony formation in serum soft agar. Using some 97 clinical strains of Staphylococcus aureus, we found that in production and activity the substances were distinctly different.

Agar↗