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Biomedical subjects

H Krueger

Publications and source records attributed to H Krueger.

71 records · Page 4Linked to original sources
PubMedDate not supplied

Effects of a low alcohol dose on static balance, fine motor activity, and mental performance.

The effects of a single low alcohol dose (men 0.54 g and women 0.44 g alcohol per kg body weight) were measured by static balance, fine motor activity, and mental performance. In 10 healthy volunteers balance was registered by a temporally and spatially high resolution platform measuring the center of foot pressure and a three-dimensional coordination measurement system. Fine motor activity and mental performance were tested with selected experiments from the NES2 (Neurobehavioral Evaluation System) neuropsychological test battery. Changes of bipedal and monopedal balance could be detected after the alcohol consumption. Neither the fine motor activity nor the mental performance test demonstrated significant effects. Thus, the static balance test proved to be a sensitive, fast, and atraumatic method to identify slight neurotoxic disturbances.

Adult↗
PubMedDate not supplied

Effects of prenatal caffeine administration on offspring mortality, open-field behavior and adult gastric ulcer susceptibility.

Pregnant rats were given caffeine (0.0%, 0.017%, 0.034% or 0.05%) in their drinking water throughout gestation. Offspring were cross-fostered to non-caffeine-treated mothers at birth. A dose-related increase in offspring mortality was observed at 24 hr and at 10 days post partum. Prenatal caffeine exposure did not significantly influence open-field ambulation or defecation when tested at 48, 68, or 196 days of age. A significant dose-related increase in restraint-stress gastric ulcer susceptibility was detected at 200 days of age. Offspring from rats treated with 0.05% caffeine during pregnancy, developed significantly more frequent and significantly more severe gastric lesions than did offspring from control rats or from rats prenatally exposed to 0.017% and 0.034% caffeine. Prenatal caffeine exposure may: (1) predispose organisms to increased gastric disease susceptibility as adults and (2) interfere with neonatal feeding ability and thereby produce infant mortality.

Animals↗