[Myelin in cerebral oligodendrogliomas in mice].
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Biomedical subjects
Publications and source records attributed to H Kroh.
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A case of medulloblastoma arising in advanced age is presented. Histologically it has anaplastic features despite desmoplastic character and astrocytic differentiation evidenced by glial fibrillary acidic protein immunoreactivity of some neoplastic cells. Neuroblastic differentiation could not be demonstrated by the neurofilament immunoreaction. A clear correlation between advanced age of the patient, the histological subtype of medulloblastoma and the direction of the tumor differentiation could not be established.
The purpose of the study was a survey of autopsy and biopsy material from 27 cases of cerebral vascular malformations for establishing the occurrence of various forms of these lesions in relation to that reported from other centres. It was tried also to check in the light of the morphological analysis of our cases the theory of vascular malformation development put forward by Kaplan et al (1961). The material comprised 4 cases of telangiectasia, 11 arteriovenous malformations, 7 cavernous haemangiomas and 5 mixed cavernomas with arteriovenous malformation. Arteriovenous malformations prevailed. The clinical manifestations set in at the age between 15 and 46 years. The analysis rather confirm the concept of Kaplan et al. that dysplasia is derived from disturbances in the development of capillaries in early embryogenesis. All other comparisons and observations were consistent with those reported in literature outside Poland.
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