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Biomedical subjects

H Kroh

Publications and source records attributed to H Kroh.

At least 73 records · Page 4Linked to original sources
PubMedDate not supplied

[Primary brain lymphomas].

In the Department of Neurosurgery of the Medical University of Warsaw 11 patients with primary central nervous system lymphomas were diagnosed and treated between 1990 and 1999. The patients comprised of 6 females and 5 males, aged 23 to 86 years, with most patients presenting in the sixth decade. The time from first symptoms to the diagnosis ranged from a few days to 5 months. In the majority of patients, the leading symptoms were: headaches, motor weakness, aphasia and memory disturbance. Initial diagnosis was based on MR in 3 patients, CT in 7 and on both CT and MR in 1 patient. The frontal lobe was the most common site of involvement. All the patients underwent surgery. The histological diagnosis was confirmed by immunohistochemical analysis using monoclonal antibodies: CD 20, CD3, CKMNF 116. In all cases, a B-cell type lymphoma was diagnosed. Radiotherapy was administered to 4 patients, 2 received chemotherapy and 1 received combined treatment. The median survival time so far is 17.6 months.

Adult↗
PubMedDate not supplied

[Intramedullary metastatic tumor. Case report].

An extremely rare case of intramedullary spinal cord metastasis (Carcinoma solidum metastaticum) is presented. No primary tumour was found. The authors discuss diagnostic and therapeutic problems of treatment in such cases.

Aged↗
PubMedDate not supplied

Heavily lipidized, calcified giant cell glioblastoma in an 8-year-old patient, associated with neurofibromatosis type 1 (NF1): report of a case with long-term survival.

Giant cell glioblastoma (GCG-BM) with predominance of bizarre, multinucleated giant cells is a rare subtype of glioblastoma, however, its clinical behavior and histological features are still not fully understood. We report an unusual case of a heavily lipidized form of giant cell glioma corresponding mostly to GCGBM in a young patient with neurofibromatosis 1 (NF1). Histologically, the tumor revealed numerous characteristic histopathological features of giant cell glioblastoma including cellular pleomorphism with numerous giant tumor cells, pseudopalisades around necrotic foci and mitotic activity, accompanied by additional unique morphological elements such as massive lipidization of the neoplastic cells, abundant microcalcifications and angiomatous pattern of vascularization. Such aberrant morphology might be associated with the unusually long survival period of 12 years without clinical evidence of tumor recurrence. The coexistence of intracerebral heavily lipidized, calcified giant cell glioblastoma with NF1 has not been previously reported in literature.

Brain Neoplasms↗
PubMedDate not supplied

Alpha-1-antichymotrypsin in human glioblastoma multiforme cells and its relation to GFAP immunostaining.

Biopsies of 20 different patients with glioblastoma multiforme were treated with 0.1% protease and stained for alpha-1-ACT. Simultaneous glial fibrillary acidic protein (GFAP) staining of mirror sections was performed. In four cases no neoplastic cells were stained with alpha-1-ACT. The other 11 cases displayed minute accumulations of immunostained neoplastic cells in spongiotic foci. Some scattered immunostained cells not differentiable from neoplastic cells were noticed. Staining of neoplastic as well as branched intratumoral astrocytes for alpha-1-ACT and GFAP of equal distribution and intensity was detected in one case. The alpha-1-ACT immunostaining of peritumoral reactive astrocytes has been observed in 8 cases, 7 of them, however with a smaller amount of cells, entirely corresponding to the distribution and intensity of GFAP. This might represent the absorption of antigen by degenerating cells.

Brain Neoplasms↗
PubMedDate not supplied

Disseminated melanomatosis of the central nervous system and other organs: a case report.

This case represents an example of clinically occult, disseminated neoplastic disease with almost asymptomatic but severe involvement of the central nervous system. The only helpful diagnostic investigation appeared to be cerebrospinal fluid cytology. Extensive post mortem examination was inconclusive as to whether the widespread CNS involvement with melanoma was primary or secondary.

Brain↗