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Biomedical subjects

H Kraus

Publications and source records attributed to H Kraus.

At least 73 records · Page 4Linked to original sources
PubMed1986

Wegener's granulomatosis with bilateral necrotizing scleritis, polyarthritis and renal failure efficiently treated with immunosuppressive therapy.

A case report of a female patient with Wegener's granulomatosis is presented. After an initial involvement of the upper respiratory tract in the form of a sinusitis, there followed a severe necrotizing bilateral scleritis necessitating the enucleation of the left eye ball. Renal involvement developed as late as 24 months after the onset of the disease and led to renal failure within three months. Throughout the duration of her disease, the patient had joint symptoms in the form of episodes of migratory nondeforming polyarthritis. The administration of corticosteroids alone in daily doses up to 60 mg prednisone failed to control the progression of the disease, while immunosuppressive therapy with cyclophosphamide combined with methylprednisolone pulse therapy and haemodialysis resulted in a marked improvement of renal function and in the subsidence of the ocular and articular symptoms.

Acute Kidney Injury↗
PubMed1986

[Value of plasma ribonuclease as a marker for gynecologic tumors and breast tumors].

In 151 patients the plasma-ribonuclease-activity was measured. The results of a control group of 47 patients were compared to the pretherapeutic values of 21 cases with cervical intraepithelial neoplasia, 83 cases with gynecologic cancer and 47 cases with breast cancer. The upper limit of the normal range was 300 ng/ml. The method is not appropriate for the detection of precancer of the uterine cervix or for breast cancer. For gynecologic tumors we found a sensitivity rate of 87% and a specificity rate of 85%.

Breast Neoplasms↗
PubMed1985

Papillomavirus infection of the lower genital tract: detection of viral DNA in gynecological swabs.

A total of 311 smears from the lower genital tract were examined by the filter in situ hybridization method to identify human papillomavirus (HPV) DNA. Of these 311 smears, 229 came from clinically and cytologically negative patients and served as a control group. In this group HPV-DNA was detected in 5 cases (2.2%). Of 82 cytologically positive cases (25 confirmed by histology) 56 (68%) contained HPV-DNA. A high prevalence of HPV 6/11 and absence of HPV 16/18 was found in cases with cytological signs of permissive HPV infection. In mild and moderate dysplasia all viruses occurred at almost the same frequency. In severe dysplasia/carcinoma in situ HPV 16/18 was found 5 times more frequently than HPV 6/11. HPV 16/18 was identified in all 4 invasive cancer cases. Cervical irrigation of colposcopically suspect areas was performed in 15 cytologically and HPV-DNA positive cases using the hydrodynamic filtration method. In 12 cases only the cells obtained from the colposcopically positive areas contained HPV-DNA. The sensitivity and reproducibility of the filter in situ hybridization was shown by: comparing the results obtained by HPV-DNA hybridization using Southern blot analysis of tumor biopsies; analysing the correlation of cytologic diagnosis and presence of HPV-DNA in follow-up examinations, and diagnosing presence or absence of HPV-DNA in parallel filters from the same patients.

Animals↗
PubMed1984

[Frequency, causes and results of dubious smear findings (Papanicolaou III group)].

Suspect smears of 842 patients from 1975-1981 were analysed for their causes and followed up until the definite cytologic or histologic result. The rate of suspect smears was between 1.44 and 0.5%. The most frequent reasons for the classification "suspect" were doubtful precancer, severe inflammatory, degenerative, or atrophic changes, abnormal glandular cells and metaplastic findings. 65% of all cases became negative under cytologic control; of these 83,6% converted to negative within half a year. Histological examination (35%) revealed cancer or precancer in 141 cases, i.e. 16.7% of the whole population. The rate of suspect smears of a laboratory should not exceed one per cent. All cases should be first controlled by means of cytology, if necessary after local treatment.

Atrophy↗
PubMed1984

[Comparative studies on general anesthesia versus peridural anesthesia in primary cesarean section].

In a prospective interdisciplinary study involving the departments of gynaecology, anaesthetics and paediatrics, the influence on both the mother and neonate of general as opposed to epidural anaesthesia was compared in 47 planned caesarean sections. Neither maternal or foetal risk factors were present in these cases, and the cardiotocogram was always normal before the anaesthetic was applied. Methods. Systolic and diastolic blood pressure were carefully monitored. Under an identical infusion regime the following parameters were estimated in maternal blood: blood gas and acid-base status, blood sugar, lactate, beta-hydroxybutyric acid, ACTH and cortisol. These same parameters were also estimated in cord blood taken at delivery. The Apgar score at 1, 5 and 10 minutes, and a complete paediatric assessment including neurostatus at 15 minutes, 24 hours and 7 days of age were used to assess neonatal status. Some of the women given a general anaesthetic initially had marked increases in blood pressure and pulse, while about a third of the epidural cases showed a blood pressure fall despite positioning in the left lateral position in order to prevent the aorto-caval syndrome. An increase in lactate, ACTH and cortisol was found in both groups up to the time of delivery, when the ACTH level of the general anaesthetic group was significantly higher. Acid-base and PCO2 values were not markedly influenced by either of the techniques used, but the maternal capillary PO2 levels were very much higher in the general anaesthetic group. The neonates born under general anaesthetic had a lower 1 min Apgar score, as a result of the relatively long induction-delivery time, of on average 17 min. The 5 and 10 min Apgar scores and the neurophysiological development of the babies revealed no differences between the two groups.

Adult↗
PubMed1983

[Normal cells and dykaryoses in vaginal smears using a high- resolution system for quantitative analysis].

In pap-stained cervical smears the cells were identified, destained and afterwards stained according to the Feulgen procedure. The measurements of the nuclei were performed on a scanning microscope photometer and 4 features were extracted for cell classification: total DNA-amount, nuclear area, degree of condensation of chromatin and granularity of chromatin. The comparison and separation of the cell groups was performed at the Computing Center of the Univ. of Ulm by 2 programs, a discriminant analysis and a specially adapted histogram. The distinction of normal cells and dyscaryoses was possible to a high degree by the features total DNA-amount and nuclear area; the 2 parameters describing the chromatin structure proved to be useless in these cases. Nuclear structure parameters were helpful in distinguishing certain types of normal cells.

Cell Nucleus↗
PubMed1983

[Complete and incomplete removal of precancerous conditions by conization].

673 patients with cervical lesions ranging from mild dysplasia to microcarcinoma have been treated by cone biopsy. There was a complete removal of the premalignant or malignant tissue in 70% of the cases, depending on the degree of severity of the lesion. In 42% of the cases (166 patients) in which hysterectomy was performed for incomplete conisation, no rests of the epithelial lesion could be found. Therefore it is recommended to follow these patients by means of cytology and colposcopy without immediate hysterectomy, especially in women who desire further pregnancies. Among 28 patients followed in this way there was recurrency only in 2 cases. In spite of "complete" conisation there were rests of cancerous tissue in 11 of 66 cases. The latter results show the necessity of a consequent follow-up also for these patients.

Carcinoma in Situ↗
PubMed1983

Evaluation of an exercise program for back pain.

A six-week exercise program for people with low back pain was established at YMCAs throughout the United States. Classes met twice weekly with trained instructors. Participants exercised at home as well. About 80 percent of the nearly 12,000 participants reported a decrease in discomfort, including those who had previously undergone back surgery. A decrease in pain correlated with adherence to the program and with measured improvement in strength and flexibility.

Back Pain↗
PubMed1983

Discrimination of normal and dyskaryotic cells with a new high-resolution system (CIALIS).

Measurements on Feulgen-stained nuclei were performed with a new high-resolution system. Squamous intermediate cells and dyskaryotic cells in cervical smears were compared, based on nuclear features: DNA content, area and two features describing nuclear structure. For data evaluation, a histogram and a linear discriminant analysis were used. The discrimination of the two cell types based on the DNA content and nuclear area was possible to a high degree. A classification based only on the two chosen descriptors of chromatin patterns was not possible.

Cell Nucleus↗