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Biomedical subjects

H Koch

Publications and source records attributed to H Koch.

At least 325 records · Page 18Linked to original sources
PubMed1980

[Vascularization of the Papilla Vateri and bleeding risk of papillotomy (author's transl)].

The vascularization of the Papilla Vateri was investigated by angiography, histology and morphometry in 55 samples obtained at autopsy; four main types may be distinguished. The bleeding risk accompanying endoscopic papillotomy in general is low because of the anatomy of the arterial supply of the papilla. The average diameter of the vessels in the plexus arteriosus papillae is about 0,98 mm, it is only 0,43 mm in the proximal part of the papilla (that is to say, the part adhering to the bile duct). The arteria retroduodenalis crosses the ductus choledochus on the average 37.5 mm from the tip of the papilla. In rare cases more excessive arterial bleeding may occur, since there is a crossing of the arteria retroduodenalis through the region of papillotomy in about 4% of the cases. A high bleeding risk exists during 8 days after the first of a multiple step papillotomy procedure, since during this period vascularization of the granulating tissue is still extensive.

Ampulla of Vater↗
PubMed1980

[Testing of bacterial mutants as potential vaccine strains].

The most important expectations made on the development of live vaccines are expounded, before a certain order is proposed according to which mutants should be tested. First, the characteristic features of the mutants should be determined with high accuracy, and the stability of these features should be established by repeated tests. Testing for harmlessness should not be undertaken until in vitro stability of a given mutant is established with certainty. The problems and possibilities associated to such tests are described by examples of Escherichia coli and Salmonella mutants. Immunogenic effectiveness of a given mutant has to be verified, after the harmlessness of the same mutant has been confirmed. Actual choice for potential use as vaccine strain will have to depend primarily on the results of an active protection experiment. The results obtained from Escherichia coli, Shigella, and Salmonella mutants are compared to those recorded from inactivated antigens.

Animals↗
PubMed1980

[Studies on tissue compatibility of d-limonene as a dissolving agent of cholesterol gallstones (author's transl)].

A 97% d-limonene preparation was injected as a bolus into the biliary tract of cats. Depending on volume, contact time, and flow direction of the solution, acute or chronic inflammatory damages for varions degrees were found in the hepatobiliary tissues of all animals treated with the d-limonene solution. These observed histopathological changes due to contact with the terpene compound, restrict the value of the d-limonene preparation as described by Igimi et al. for dissolving cholesterol gallstones retained in the human common bile duct.

Animals↗
PubMed1979

Silymarin, an inhibitor of lipoxygenase.

Silybin (I), silydianin (II) and silychristin (III), the constituents of silymarin, non-competitively inhibit the lipoxygenase from soybeans (EC 1.13.11.12) in vitro.

Flavonoids↗
PubMed1979

Silymarin, an inhibitor of prostaglandin synthetase.

Silybin (I), silydianin (II) and silychristin (III), the main constituents of silymarin, inhibit the formation of prostaglandins in vitro. The inhibition is log-linearly dependent on the concentration of the effectors.

Animals↗
PubMed1979

[Endoscopic papillotomy (author's transl)].

Endoscopic papillotomy is a method of incising the papillary spincters without opening the abdominal wall or the duodenum. It is successful in over 95% of cases. In over 80% of cases passage of choledochus concrement occurs, about half of these stones being excreted spontaneously and the rest having to be extracted actively with a small Domia basket. For large concrements which cannot be removed endoscopically even after wide papillotomy incision, there is the electrohydraulic lithotrite which crushes them so that they can be passed spontaneously or be actively extracted. Dissolution by a substance instilled through a catheter passed through the papilla into the common bile duct is still in the experimental stage. Altogether for this reason endoscopic papillotomy and removal of stones is an advance for the patient at risk, as it involves a lower lethality than the corresponding surgical method.

Ampulla of Vater↗
PubMed1979

Individual messenger RNA half lives in Saccharomyces cerevisiae.

We have measured the decay half-life of functional messenger RNA (mRNA) for some thirty different proteins in the yeast Saccharomyces cerevisiae. Production of newly synthesized mRNA was halted by raising the temperature of a culture of a temperature-sensitive mutant, ts 136. Aliquots of this culture were pulsed-labelled with [35S]-methionine at various times after the temperature shift and the radioactive proteins separated on the two-dimensional gel electrophoresis system of O'Farrell. We find a range in the decay half lives of individual mRNA species which varies from 3.5 min to greater than 70 min. We find three general classes of decay curves, (a) simple exponential (first order); some of these showed a shoulder before onset of exponential decay; (b) bi-component or multi-component concave upward; (c) initial stimulation of rate of mRNA synthesis, followed by virtually undetectable decay.

Electrophoresis↗
PubMed1979

Pharmacokinetics and metabolism of taglutimide (K-2004) in the rat.

Absorption, blood level course, renal, fecal, and biliary elimination and the metabolisation of 2-(bicyclo[2,2,1]-heptane-2-endo-3-endo-dicarboximido)-glutarimide (taglutimide, K-2004), a new hypnotic-sedative substance, were studied in the rat, and the pharmacokinetic constants were calculated. After oral administration of 10 mg per animal, which corresponds to the 7- to 10-fold human dose, a fast and practically total absorption and a quick and complete excretion was observed. Within 1 h 82% of the dose given were absorbed, and 12 h after the dosing 88% had been excreted again. The elimination was effected nearly exclusively (over 95%) via the urine. Besides 10 defined metabolites only 10% of the drug appeared unchanged.

Animals↗
PubMed1979

[Chronic pancreatitis: diagnostic value of endoscopic retrograde pancreaticography, of pancreatic sonography, and of secretin-pancreozymin test corrected for volume losses (author's transl)].

Endoscopic retrograde pancreaticography (ERP) and secretin-pancreozymin test corrected for losses (SP test) were performed in 153 patients suspected to have pancreatic disorders in order to evaluate diagnostic significance of these procedures. Pancreatic sonography was done in addition in 110 of these patients. If pancreatic excretion was normal, ERP results turned out to be normal in the same patients as well. SP test involves rather extensive laboratory work-up, but it does yield the most precise results as far as diagnosis of chronic pancreatitis is concerned. For this reason, and because of the possible complications caused by ERP, ERP should be applied only, when surgery is considered. Results of SP test and sonography coincided rather well. Therefore, sonography, not doing any harm to the patient, does have its place in the diagnosis of chronic pancreatitis.

Cholecystokinin↗