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H Kesteloot

Publications and source records attributed to H Kesteloot.

At least 37 records · Page 2Linked to original sources
PubMed2000

Cancers, mainly male, as population biomarkers for breast cancer mortality.

BACKGROUND: BCM correlates significantly with mor tality from other site-specific cancers and cardiovascular diseases for both sexes. These other mortalities could be used as independent biomarkers (predictors) of BCM allowing an evaluation of the importance of common etiological factors. METHODS: BCM (age-adjusted, 45-74 years), obtained around 1992 from 37 countries worldwide, was estimated in multivariate regression to identify the best predictors. RESULTS: Male and female biomarkers predicted BCM with a R(2) of 0.80 and 0. 69, respectively. Strongest correlation was obtained with male colon, prostate, lung, and rectum cancer and female esophagus cancer (R(2) = 0.84, P < 0.0001). The estimated independent mean percentage contribution +/- SD to BCM was 40 +/- 7 from prostate cancer, 38 +/- 9 from male colon, 13 +/- 6 from male lung and rectum cancer combined, and 9 +/- 3 from female esophagus cancer. The regression equation (1992 data) predicted mean BCM in 28 available countries from 1967 to 1991 with a mean error of 5%. BCM in individual countries was also reliably predicted from 1967 to 1991, r = 0.86 to 0.90 (P < 0.0001). In 1953, r was 0.74 (P < 0.0001). CONCLUSIONS: The evidence suggests a major influence of modifiable environmental factors common to BCM, its biomarkers, and both sexes: most likely nutrition, smoking, and alcohol intake. The results obtained with male data suggest a minor impact of sex-linked risk factors and, until recently, of treatment and early detection on BCM at the population level.

Aged↗
PubMed2000

Fish consumption is inversely associated with male lung cancer mortality in countries with high levels of cigarette smoking or animal fat consumption.

BACKGROUND: A striking difference in fish consumption and lung cancer mortality (LCM) exists among populations worldwide. This study investigated the relation between fish consumption and LCM at the population level. METHODS: Sex-specific LCM data, mostly around 1993 and fish consumption data for 10 periods 1961-1994 in 36 countries were obtained from WHO and FAO, respectively. RESULTS: A significant inverse correlation exists between log fish consumption and LCM rate in 9 out of the 10 time periods (r = -0.34 to r = -0.46, P = 0.044 to P = 0.005). After adjusting for smoking and other confounders, log fish consumption (% of total energy [% E]) was inversely and significantly associated with LCM rate (per 100 000 per year) in all 10 time periods (beta = -26.3 to beta = -36.7; P = 0.0039 to P < 0.0001). The stratified analysis showed that this inverse relation was significant only in countries with above median level of smoking (>2437 cigarettes/adult/year) or animal fat minus fish fat consumption (22.4% E). An increase in fish consumption by 1% E was calculated to reduce mean male LCM rate of the populations examined in the age class of 45-74 years by 8.4%. In women, no significant relation between fish consumption and LCM could be established. CONCLUSIONS: Fish consumption is associated with a reduced risk from LCM, but this possible protective effect is clear-cut only in men and in countries with high levels of cigarette smoking or animal fat consumption.

Aged↗
PubMed1999

Fish consumption and mortality from all causes, ischemic heart disease, and stroke: an ecological study.

BACKGROUND: The present study examined the relation between fish consumption and mortality from all causes, ischemic heart disease, and stroke. METHODS: The fish consumption data in 1961-1963, 1979-1981, and 1989-1991 and mortality data, age-standardized to 45-74 years, mean of the latest available 3 years, mostly around 1992-1993, in 36 countries, were obtained from the Food and Agriculture Organization and the World Health Organization, respectively. RESULTS: There exists an inverse univariate correlation between log fish consumption in 1961-1963, 1979-1981, and 1989-1991 and log all-cause (P < 0.01 to < 0.001) and ischemic heart disease (P < 0.05 to < 0.01) mortality in both sexes. An inverse univariate correlation between log fish consumption and log stroke mortality was found only for the period 1961-1963 in both sexes (P < 0.05). Log fish consumption was independently, significantly, and inversely associated with log all-cause (all P < 0.001), ischemic heart disease (P < 0.01 to < 0.001), and stroke (P < 0.05 to < 0.001) mortality in all three time periods in both sexes, after adjusting for confounding factors. These associations remained significant even after exclusion of Iceland and Japan, countries with the highest amount of fish consumption and the lowest all-cause mortality rate. CONCLUSIONS: Fish consumption is associated with a reduced risk from all-cause, ischemic heart disease, and stroke mortality at the population level.

Age Distribution↗
PubMed1999

Intake of fatty acids in western Europe with emphasis on trans fatty acids: the TRANSFAIR Study.

OBJECTIVE: To assess the intake of trans fatty acids (TFA) and other fatty acids in 14 Western European countries. DESIGN AND SUBJECTS: A maximum of 100 foods per country were sampled and centrally analysed. Each country calculated the intake of individual trans and other fatty acids, clusters of fatty acids and total fat in adults and/or the total population using the best available national food consumption data set. RESULTS: A wide variation was observed in the intake of total fat and (clusters) of fatty acids in absolute amounts. The variation in proportion of energy derived from total fat and from clusters of fatty acids was less. Only in Finland, Italy, Norway and Portugal total fat did provide on average less than 35% of energy intake. Saturated fatty acids (SFA) provided on average between 10% and 19% of total energy intake, with the lowest contribution in most Mediterranean countries. TFA intake ranged from 0.5% (Greece, Italy) to 2.1% (Iceland) of energy intake among men and from 0.8% (Greece) to 1.9% among women (Iceland) (1.2-6.7 g/d and 1.7-4.1 g/d, respectively). The TFA intake was lowest in Mediterranean countries (0.5-0.8 en%) but was also below 1% of energy in Finland and Germany. Moderate intakes were seen in Belgium, The Netherlands, Norway and UK and highest intake in Iceland. Trans isomers of C18:1 were the most TFA in the diet. Monounsaturated fatty acids contributed 9-12% of mean daily energy intake (except for Greece, nearly 18%) and polyunsaturated fatty acids 3-7%. CONCLUSION: The current intake of TFA in most Western European countries does not appear to be a reason for major concern. In several countries a considerable proportion of energy was derived from SFA. It would therefore be prudent to reduce intake of all cholesterol-raising fatty acids, TFA included.

Adult↗
PubMed1999

Sex ratio of total energy intake in adults: an analysis of dietary surveys.

OBJECTIVE: The ratio of the total energy intake (TEI) reported by men and women in the same dietary survey varies considerably among dietary surveys. The purpose of our study was to investigate the potential value of the sex ratio of TEI as a measure of misreporting dietary intake by comparing it with the sex ratio of biomarkers such as the 24 h urinary excretion of sodium, potassium and total nitrogen. METHODS: The sex ratio (m/f) of TEI in adults was calculated from 81 dietary surveys performed in 28 countries. The surveys were conducted in healthy and free-living populations, using the same methodology in both sexes. RESULTS: A mean sex ratio of 1.35 (s.d., 0.13) and 1.33 (s.d., 0.10) was obtained at the individual survey level and at the country level, respectively. The sex ratio of 1.40 in the younger age class (< or = 60/64 y) was significantly higher than the sex ratio of 1.27 in the older age class (> 60/64y) (P < 0.0001). The dietary assessment methodology also influenced the sex ratio (P = 0.03). Compared with the INTERSALT study, the sex ratio of TEI was higher than the sex ratios of the 24 h urinary sodium (1.23), potassium (1.20) and total nitrogen (1.25), biomarkers of dietary sodium, potassium and protein intake. Therefore the dietary survey data indicate a mean TEI of 10 476 kJ/d for men and 7784 kJ/d for women, which gives a mean sex difference of 2692 kJ/d. However if the biomarker sex ratio of 1.23, mean sex ratio of the 24 h urinary sodium, potassium and total nitrogen, is correct and the TEI of men is correctly assessed at 10476kJ/d, the TEI of women should be 8517kJ/d, a difference of only 1959 kJ/d. CONCLUSIONS: Calculated from dietary surveys, the mean sex ratio of TEI is 1.35. This sex ratio decreases with age and depends on the dietary assessment methods used. In many dietary surveys, the sex ratio of TEI is likely overestimated.

Adult↗
PubMed1999

Anthropometric, lifestyle and metabolic determinants of resting heart rate. A population study.

AIM: To clarify the determinants of resting heart rate at the population level in a random sample of the Belgian population. METHODS AND RESULTS: Data of 5027 men and 4150 women aged 25-74 years obtained from a Belgian nationwide survey were analysed. In multivariate analysis, blood pressure strongly correlated with heart rate in men (t = 12.4 for systolic; t = 8.8 for diastolic) and women (t = 12.0 for systolic; t = 7.7 for diastolic). Age (t = -3.4 in men; t = -8.1 in women) and height (t = -3.7 in men; t = -3.1 in women) correlated negatively with heart rate. Smoking raised heart rate in men (1-19 cigarettes.day-1, t = 6.1; > or = 20 cigarettes.day-1, t = 10.3) and women (> or = 20 cigarettes.day-1, t = 3.5). Serum phosphorus correlated negatively with heart rate (t = -3.5 in men; t = -8.3 in women). Serum log alkaline phosphatase (t = 6.7 in men; t = 7.2 in women) and serum protein (t = 5.3 in men; t = 4.4 in women) correlated positively with heart rate. CONCLUSION: At the population level, blood pressure, cigarette smoking, serum alkaline phosphatase and serum protein correlate independently, significantly and positively with heart rate, and age, height and serum phosphorus negatively.

Adult↗
PubMed1999

[Female mortality: lessons from geopathological comparisons].

Worldwide a highly significant correlation exists between male and female mortality, particularly for all-cause, cardiovascular and cerebrovascular mortality, but to a lesser degree for cancer. This shows that the same factors are the major determinants of mortality in both sexes. Mortality from all causes over the age range 35-84 years can adequately be expressed by Gompertz equations (log mortality versus age), of which the intercepts are lower and the slopes higher in women compared to men. The demonstrates that ageing progresses more slowly in women. Maximum life expectancy is slightly higher in women. The various causes of mortality are competitive.

Adult↗
PubMed1999

On the determinants of mortality at the population level.

To attain a long and healthy life has always been one of the major goals of humanity. The Chinese emperors, the Egyptian pharaohs and the Aztec kings all aspired to become immortal. To try to avoid mortality and to decrease morbidity at the population level is the role of public health, taken in its broadest sense, including both preventive and curative medicine. In this review we will try to identify the major determinants of mortality. Only when we are able to identify the major causes of mortality and morbidity can public health be approached in a rational way. The emphasis will be on mortality because, in our opinion, populations with a long life expectancy also have a low age-specific morbidity.

Cardiovascular Diseases↗
PubMed1999

Regional differences in mortality: a comparison between Austria, Hungary and Switzerland.

BACKGROUND: Important differences in mortality rates exist even between neighbouring countries. This should facilitate the identification of the lifestyle parameters underlying these differences. The mortality rates obtained in Hungary, Austria and Switzerland were compared. METHODS: The mortality rates for all-cause, total cardiovascular, total cancer and stroke mortality were obtained from a special tape from WHO. Nutritional data were obtained from FAO food balance sheets and from dietary surveys. Gompertz and polynomial equations were calculated from the age-specific mortality rates. FINDINGS: Great differences in mortality exist between the three countries. In the period from 1950 until 1995 mortality decreased in Austria and Switzerland, but increased in Hungary. In men, total cancer and total cardiovascular mortality also increased markedly in Hungary during the last 20 years. Hungary has a lower dietary P/S ratio, a higher level of animal/vegetal fat and a lower consumption of fruit than Austria and Switzerland, combined with a high level of salt consumption. The level of cigarette smoking is similar in Hungary and Switzerland. The increase in mortality rate in Hungary is less pronounced in women than in men. INTERPRETATION: The major differences in lifestyle between the three countries concern socio-economic and nutritional patterns. Epidemiological evidence favours nutrition as the most important determinant of the differences in mortality rates between the three countries.

Adult↗
PubMed1998

Nutritional habits and serum lipid levels in a low-fat intake Chinese population sample.

The dietary intake of macronutrients and of specific minerals and vitamins was measured in a low-fat intake adult population living in a rural area in northwestern China. The total intake of fat amounted to +/- 12% of total energy. The P/S ratio was 2.5 and the U/S ratio 3.8. Carbohydrates provide about 75% of total energy. The mean total serum cholesterol was 148 mg/dl in men and 163 mg/dl in women. The mean HDL-cholesterol level was 38.6 mg/dl in men and 39.4 mg/dl in women, confirming the absence of a significant sex difference in HDL-cholesterol in low-fat consuming populations. Triglyceride levels were similar to those of Western populations. For both sexes taken together a positive correlation was found between the serum cholesterol level and saturated fat intake (p < 0.001) and a negative correlation with the P/S ratio (p < 0.05). Calcium intake was low: 346 mg/d in men and 245 mg/d in women.

Adult↗