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Biomedical subjects

H Keller

Publications and source records attributed to H Keller.

At least 271 records · Page 15Linked to original sources
PubMed1982

[Results of continuous permanent irrigation in diffuse purulent peritonitis].

In a prospective study continuous peritoneal lavage was carried out in 30 patients with diffuse purulent or fecal peritonitis using a volume of 20-50 1/24 h during 5-7 days. Bacteria were recognised in the effusate until day 5. Protein losses per 24 hours amounted to 4,1-46 g. A mean value of 14,5 +/- 14 g was determined. The fractional protein clearance of IgG had increased compared to other proteins. A mortality of 26,7% was obtained. Death causes were the consequences of septic shock. In none of the investigated cases remaining empyemas in the peritoneal cavity could be shown. There was no support for the establishment of lavage tracks.

Adolescent↗
PubMed1981

[Inquiry on the use of cephalosporins in Switzerland].

In July of 1980 an inquiry was conducted on the use of cephalosporins (CS) in Swiss hospitals. 387 senior physicians answered the questionnaire with reference to the following points: -- Frequency of CS administration compared with the use of aminopenicillins and of combinations of several penicillins. -- Reasons for switching from one CS to another CS derivative. -- Major indications and principles of CS administration. -- Frequency of oral administration of CS. -- Use of CS in bacterial meningitis and in infections by anaerobic bacteria. -- Combination with aminoglycosides. -- Preference to particular CS derivatives. In the light of practical experience and a multitude of additional comments by the respondent physicians, an attempt is made to define guidelines for CS application.

Administration, Oral↗
PubMed1981

[Haemodynamic effects of intraarterial contrast injections (author's transl)].

Intra-arterial contrast injections have well known systemic and pulmonary vascular effects; in addition there are local haemodynamic changes which begin immediately after the injection and last for several seconds. Three phases can be recognised: Phase 1 Increased flow, pressure and turbulence due to transmission of kinetic energy from the contrast medium to the vessel contents. Phase 2 Reduced flow due to the high viscosity of the contrast medium. Phase 3 Increased flow, probably a pharmacological results produced by contrast (osmolarity). The effects of contrast injection can be altered by changes to the catheter or to the properties of the contrast medium. This has practical consequences for injection techniques and for flow measurements. While assessing the clinical usefulness of the "spill over" flow measurements described by Olin and Redman in 1966, we concluded that the haemodynamic effects of the contrast lead to significant falsification of the measurements, and this also has some significance for the performance of angiography. We have therefore studied this phenomenon, its causes and the factors which influence it, on a model and in animal experiments. In order to quantify changes in flow caused by the injection during animal experiments, a study was carried out on the effects of contrast media on electromagnetic measurements.

Angiography↗
PubMed1981

Automated pattern analysis of growing rat lung.

This study discusses the use of automatic image analysis equipment in quantifying the structural changes during growth of rat pulmonary parenchyma. At birth the latter consists of primary septa delineating a coarse structure of alveolar sacs which are then subdivided into alveoli by outgrowth of secondary septa from day 4 onwards. This process is followed by internal restructuring of the septa in the third week which further increases the surface area by formation of small irregularities. A partial quantification of these processes was obtained by measuring the full set of parameters available with the Quantimet 720 using light microscopy on rat lung sections at the ages of 4, 10 and 21 days. This yielded basic data, e.g. volume and surface densities of air space and tissue. Using closure and opening as preprocessing operations made it possible to split up such parameters into contributions from different ranges of detail resolution. The mass of eighty-four variables obtained could be reduced to six independent factors by Factor Analysis techniques. Interpretation through their correlation with the original variables yielded septal surface, septal volume, minor and major axes of the large air spaces, and surface detail as important structural descriptors explaining 70% of total variance. The remainder is attributed to between-field variations.

Animals↗
PubMed1981

The likelihood quotient line, a tool for the assessment of diagnostic validity of clinical chemical tests.

A detailed study of decision criteria for detection of Edema Proteinuria Hypertension (EPH) gestosis on the basis of uric acid concentration in serum has been recently described by Haeckel et al. (1981) J. Clin. Chem. clin. Biochem. 19, 173-176). These authors compared Receiver Operating Characteristic (ROC) Curve analysis, the determination of maximum efficiency, and the maximal information content. We recently developed a method of resolving this type of decision problem using the so-called Likelihood Quotient line (LQ line) which is also useful for assessing the validity of quantitative tests with respect to particular clinical decision problems (Keller, H & Gessner, U. (1981) Med. Lab. 34, 3-7; 31-39; Z. Med. Lab. Diagn. 22, 179-188). In this communication we demonstrate our approach using the same example as Haeckel et al., compare the results, and discuss further advantages of the LQ line.

Clinical Laboratory Techniques↗