Biomedical subjects
H Kaur
Publications and source records attributed to H Kaur.
Bronchopulmonary candidosis.
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Serological study of brucellosis in man in Punjab.
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Ankyloblepharon filiforme adnatum, case report.
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Segregation distortions for the ABO system in pairs of sibs.
The influence of maternal phenotype was observed in 471 consecutive sib pairs to explore the segregation distortions for the ABO system. The ABO typing was done using the standard technique of haemagglutination reaction and the sib pairs were named according to their phenotypes. Thus A-B is the pair where first sib was A and the consecutive one was B. The statistical computations involved calculations of ABO gene frequencies, and application of chi-square and Z test for proportions to study the segregation distortions in sibs. A significant excess of B gene in the first sib and reduction of O in the second sib was observed when the Z test was applied to study the covariance, whereas no significant distortions were observed with simple Chi-square test. Heterozygote AO mothers segregated insignificantly in favour of A allele whereas BO mothers segregated significantly in favour of B allele in the first as well as in the second sib indicating that selection is favouring the B gene in our population.
True heartburn: a case of gastropericardial fistula.
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Seroprotection following Enivac-HB, a recombinant hepatitis B vaccine.
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Tumors of the liver, bile duct, and pancreas.
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Lipoprotein(a) as an independent risk factor for coronary artery disease in patients below 40 years of age.
Coronary artery disease has assumed alarming proportions in Indians and often affects people at younger age. Traditional risk factors fail to explain the high incidence of disease. Although lipoprotein(a) has been shown to be a powerful risk factor for atherosclerosis, there is very limited data with regard to its significance in premature coronary artery disease. The present study was therefore undertaken to assess lipoprotein(a) levels and its role as a marker of coronary artery disease in patients below the age of 40 years. Lipid profile and lipoprotein(a) levels were estimated in 50 patients of angiographically proven coronary artery disease and an equal number of age-matched healthy controls. There was no significant difference in the family history of coronary artery disease, body mass index and waist-hip ratio between the two groups. Total plasma cholesterol, triglyceride and LDL-cholesterol levels were significantly higher and HDL-cholesterol significantly lower in patients as compared to controls. In patients of coronary artery disease, mean lipoprotein(a) levels, measured by ELISA method, were 35.0 +/- 32.4 mg/dL and the median was 26.7 mg/dL. These values were significantly higher than the mean of 20.3 +/- 17.0 mg/dL (p < 0.002) and the median of 13.8 mg/dL (p < 0.015) in controls. Multiple regression analysis, to assess the influence of various risk factors, showed that low HDL-cholesterol (odds ratio 4.62, 95% CI 1.84-11.60; p < 0.015) and elevated lipoprotein(a) levels (odds ratio 3.06, 95% CI 1.24-7.55; p < 0.001) were independent risk factors, whereas high total cholesterol and triglyceride levels did not have any independent influence on premature coronary artery disease. Our data thus suggest that lipoprotein (a) levels are elevated and constitute an independent risk factor in patients with premature coronary artery disease below 40 years of age.
Maternal mortality -- aetiological factors: analytic study from a teaching hospital of Punjab.
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Role of sonography in placenta previa.
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Epidemiology of hepatitis E and A in Ludhiana.
AIM: To study the epidemiology of hepatitis E and A in Ludhiana. METHODS: A retrospective analysis of laboratory data of the year 2001 was done, to study the epidemiology of hepatitis E and A in Ludhiana in relation to prevalence, age, sex, area of residence and seasonal variation. RESULTS: Prevalence of HEV was 13.9%. Infection with it occurred through out the year with no preponderance of cases following the monsoons. Young male adults between 20-40 years of age were predominantly affected. Prevalence of HAV was 5.5% affecting mainly children below 14 years of age. Population of urban areas around "Gandha Naliash" (a large open sewer) was at high risk as there was clustering of HEV & HAV cases around that area.
Cryptosporodium infection in patients of diarrhoea in Ludhiana.
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Induction of lepromin positivity by a candidate anti-leprosy vaccine Mycobacterium w in lepromin negative healthy contacts of multibacillary leprosy patients.
In a hospital based study, 362 household contacts of multibacillary leprosy patients were screened for evidence of leprosy and 54 (14.9%) were found to be having leprosy. The remaining 308 apparently healthy contacts were lepromin tested and 109 (35.4%) were observed to be negative to Mitsuda lepromin. M.w vaccine was administered intradermally to 95 of these 109 lepromin negative contacts. Sixty eight of them could be retested for lepromin A reactivity. Fifty six (82.35%) manifested lepromin conversion. The twelve subjects who did not show lepromin conversion, received a second dose of the vaccine, and eleven subsequently became lepromin positive. The overall lepromin conversion rate was thus 98.5% (67 out of 68). Follow-up of these contacts upto a period of 30 months did not demonstrate reversion of lepromin positivity back to negativity status. No untoward effects of vaccination were observed except for local ulceration at the site of vaccine administration.
Neuronal conduction studies of the median nerve in non-impaired humans: a comparison of accepted techniques.
BACKGROUND AND PURPOSE: There are two commonly accepted techniques used for distal electro-stimulation placement when performing median motor nerve conduction studies. The purpose of this study was to compare latency using two commonly accepted sites of distal stimulation of the median nerve when performing motor nerve conduction studies on non-impaired adult humans. PARTICIPANTS: The sample consisted of 36 non-impaired participants (15 female, 21 male) aged 20 to 40 years. METHODS: Participants were randomly assigned to two groups and tested bilaterally for the median motor nerve. For distal stimulation of the median motor nerve, in the first group, 8 cm was measured from the center of the muscle diagonally to arrive at a point between the flexor carpi radialis and plamaris longus tendons. In the second group, 3.5 cm was measured from the distal wrist crease proximally along the median nerve for the distal stimulation of the median motor nerve. Distal latency of both techniques was obtained. Surface skin temperature of the palm was recorded throughout the procedures. RESULTS: No significant differences were found between the 8 cm and 3.5 cm techniques at p < or = 0. 05 level. COMMENT: Even though no differences were found between the two techniques, the 3.5-cm technique is recommended because of its consistency as an anatomical landmark reducing the potential for measurement error.
A microbiological study of bottled mineral water marketed in Ludhiana.
The microbiological quality of bottled mineral water marketed in Ludhiana was examined, Twenty three brands were analyzed for presumptive coliform count by multiple tube tests, and E. coli count was confirmed by Eijkman test. Bacterial and fungal loads were tested by membrane filtration test. Out of 23 only one sample (4.4%) showed the presumptive coliform count to be 460 most probable number (MPN)l 1 00ml,and 1 was found to be positive when tested by Eijkman test for Ecoli. In the membrane filtration test three samples (13%) showed more than two types of bacteria. Different types of bacteria isolated included Bacillus sp (19/23). Pseudomonas spp (13123), Ecoli, Klebsiella sp and S.albus one each Fungi was isolated from five of twenty three. (22%) samples. Only one brand of mineral water was unfit for human consumption. The rest of the samples were contaminated with non pathogenic flora.
Sciatic nerve in experimental leprosy.
Swiss albino mice were inoculated with Mycobacterium leprae obtained from untreated lepromatous patients. Histopathological study of sciatic nerves showed no abnormality. However a few free acid fast bacilli (AFB) were detected in the sciatic nerves taken from the inoculated limbs during the early stages of infection, suggesting the nerve-fibre route of travel as seen in humans in experimental leprosy, too.
Circulating immune complexes in normal and immunosuppressed mice infected with Mycobacterium leprae.
Mycobacterium leprae infection was produced through the footpads in normal and immunosuppressed mice. Circulating immune complexes were detected by specific binding test and by conglutinin binding assay for specific and total immune complexes respectively in the sera of these mice during different periods of infection. Out of the total 30 samples tested from the infected groups, 3 were positive by specific binding test and 5 by conglutinin binding ELISA. The implications of the findings in relation to human leprosy are discussed.