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Biomedical subjects

H Kamiya

Publications and source records attributed to H Kamiya.

At least 505 records · Page 28Linked to original sources
PubMed1981

Application of live attenuated measles and mumps vaccines in children with acute leukemia.

Eight children with acute leukemia in remission were immunized with live attenuated measles vaccine and 4 with mumps vaccine. Immunological examinations before vaccination showed that the numbers of white blood cells, percentages of lymphocytes, levels of immunoglobulins and responses to skin tests with DNCB, PPD, PHA and varicella antigen were within normal ranges in most of these children. Chemotherapy against leukemia was stopped for 2 weeks, from one week before to one week after vaccination. One child had a transient fever 10 days after measles vaccination, but no side reactions were observed in the others. Seroconversion was observed in all but one child who received measles vaccine, and neutralizing antibodies have persisted for at least 4 weeks and at most 3 years, when this study was terminated.

Acute Disease↗
PubMed1980

Marine biopolymers with cell specificity. II. Purification and characterization of agglutinins from mucus of windowpane flounder Lophopsetta maculata.

The windowpane flounder, Lophopsetta maculata, was found to have proteins in the body mucus which agglutinate mouse leukemia cells, L5784Y but not L1210. They also agglutinate rabbit and mouse erythrocytes, a marine yeast and a bacterium, and have weak activity against mouse sarcoma 180 cells, human B, guinea pig, and horse erythrocytes. The hemagglutinating activity was not affected by the treatment with 2-mercaptoethanol, trypsin, or pronase, but was inhibited by a high concentration of N-acetylneuraminic acid. The major active component was purified and found to be a protein having a molecular weight of 68 000 which dissociates into subunits of equal size (16 000). Isoelectrofocusing gave two sharp bands, close together, at pI 4.7 +/- 0.1. The protein contains high amounts of aspartic acid, glutamic acid and glycine, and very little histidine and half-cystine.

Agglutinins↗
PubMed1980

[Fundamental and clinical studies of cefoperazone in pediatric patients (author's transl)].

1. Susceptibility, concentrations in serum and spinal fluid, and clinical effect of cefoperazone (CPZ), a newly developed cephalosporin in Japan, were examined in 28 infants from 2 days to 12 years of ages with various infections. 2. The overall clinical evaluation in 22 cases received CPZ alone was found to be markedly effective in 11 cases and effective in 6 cases; the efficacy rate was as good as 85.0%. 3. The mean half-life following a single intravenous injection of 25 mg/kg to 3 infants was 80.7 minutes. 4. The side effects observed during the therapy were 2 cases of rash and 1 case of vascular pain and these symptoms improved after interruption of therapy. The side effects of CPZ seemed to be not more noticeable than other cephalosporins.

Age Factors↗
PubMed1980

Annual fluctuation of Schistosoma japonicum infection in field rats, Rattus rattus mindanensis, in Dagami, Leyte, Philippines.

The annual fluctuation of Schistosoma japonicum infection in field rats, Rattus rattus mindanensis, in Leyte, the Philippines was investigated. One hundrend live-traps were set for one week every month from February, 1978 to February, 1979, in and around Central Elementary School II, Diagami, Leyte. Out of 199 rats, 163 (81.9%) were infected. The prevalence rate of S. japonicum infecton in rats was high during the relatively dry season, April to July, 1978. Meanwhile, the prevalence rate of schistosome cercariae in Oncomelania quadrasi of the study area increased during the relatively rainy season, October, 1978 to February, 1979. It is supposed that miracidia hatched from eggs discharged in the feces of rats during the relatively dry season would encounter snails, following which the emerging cercariae would penetrate the mammalian hosts, such as humans and rats, during the relatively rainy season. This might be the transmission dynamics of schistosomiasis in the endemic areas of Leyte. It is also suggested that this annual prevalence rate could be used as a parameter to formulate and evaluate control works. No infection was established in the youngest age group, the weanling. Then, the prevalence increased gradually by age. All rats of the older age group were infected. According to age composition, the field rat had no definite breeding season in Leyte. COP reaction was weak in sera of infected rats, but strongly exhibited in sera from rats possessing eggs in the spleen. Consequently, field rats not only maintain the infection as reservoir hosts, but also are an important source of infection as definitive hosts in the endemic areas of Leyte Island. Specifically, the rat role must be stressed, should human schistosomiasis ever be controlled.

Animals↗
PubMed1980

The emergence of Schistosoma japonicum cercariae from Oncomelania quadrasi.

The release of Schistosoma japonicum cercariae from Leytean Oncomelania quadrasi snails was observed under laboratory conditions. Two patterns of emergence were noted. The initial, nonperiodic emergence occurred immediately after submerging the snails in water and was followed by a periodic, diurnal emergence which peaked in the afternoon. The daily cercarial output of the periodic emergence appeared to be affected by exogenous light intensity. Furthermore, there was a cessation or reduction in cercarial output every 3rd or 4th day.

Animals↗
PubMed1979

Purification and characterization of an agglutinin in the red alga Agardhiella tenera.

The red alga, Agardhiella tenera was found to contain a glycoprotein which agglutinates mouse leukemia cells, L5178Y but not L1210. It also agglutinates guinea pig and rabbit erythrocytes, and has weak activity against human A, B and O, mouse, horse and sheep erythrocytes and hamster and mouse lymphocytes. The agglutination was not inhibited by simple sugars. The major active component was purified and determined to be a beta-structure protein containing 2.7% glucose as sugar moiety. The molecular weight was estimated to be 12,000 by gel filtration and 13,000 by polyacrylamide gel electrophoresis, in the presence of sodium dodecylsulfate. Its isoelectric point was 6.1, and it contained high amounts of glycine, serine and threonine, but no half cystine or histidine. It had no subunit structure, and the C- and N-terminal amino acids were threonine and arginine, respectively.

ABO Blood-Group System↗
PubMed1979

In vivo direct effects of cholinergic agents on the inferior mesenteric and cardiac ganglia with relation to their receptors in the dog.

The relative contribution of nicotinic and muscarinic receptors to the cholinergic transmission of the inferior mesenteric ganglion was studied in spinal dogs by recording changes in perfusion pressure of the inferior mesenteric artery as an indicator of ganglionic function. Preganglionic stimulation elicited a frequency (2.5--320 Hz)-dependent rise in the perfusion pressure, which was inhibited by i.v. hexamethonium (C6) (10 mg/kg) or atropine (0.1 mg/kg) administered after C6. Acetylcholine (ACh) (0.1--1000 microgram) administered into the inferior mesenteric artery to reach the mesenteric ganglion induced a dose-dependent rise in perfusion pressure and this dose-response curve was shifted to the right by C6 or atropine. Bethanechol (1--1000 microgram) i.a. produced a dose-dependent rise in the pressure, which was abolished after i.v. atropine. Tetramethylammonium (1--300 microgram) i.a. elicited an increase in the pressure thought the effects were decreased at larger doses, and these effects were strongly inhibited by i.v. C6. ACh (5--100 microgram) administered into the right subclavian artery to reach the cardiac sympathetic ganglia caused a dose-dependent positive chronotropic effect, which was inhibited by i.a. C6 or atropine. The results suggest that the inferior mesenteric ganglion seems to differ from the cardiac ganglia in relative contribution of nicotinic and muscarinic receptors to the cholinergic transmission.

Acetylcholine↗