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Biomedical subjects

H Kaiser

Publications and source records attributed to H Kaiser.

At least 127 records · Page 7Linked to original sources
PubMed1983

Magna-field irradiation and autologous marrow rescue in the tratment of pediatric solid tumors.

Marrow ablative therapy has been given to pediatric patients with a variety of disseminated tumors. Eight patients with advanced neuroblastoma received autologous marrow reinfusion after intensive therapy. Three of eight are in continus complete remission for 7 to 60 months. An additional four patients received allogeneic marrow transplantation and two remain in continuous complete response at 21 and 39 months. Intensive therapy and autologous marrow reinfusion have been applied to Ewing's sarcoma, but only preliminary results are available. Six patients with disseminated rhabdomyosarcoma and extra-osseous Ewing's sarcoma received conventional chemotherapy followed by sequential hemi-body irradiation. Four of six patients received autologous marrow rescue. Their median disease-free survival is 17 months. This preliminary experience demonstrates the feasibility of using marrow ablative therapy with autologous marrow transplantation in the treatment of pediatric solid tumors. Continuing Phase II studies are required to substantiate its efficacy.

Adolescent↗
PubMed1983

Development of tolerance during nitrate therapy: dissociation of arterial and venous effects. A doppler echocardiographic study.

Using pulsed Doppler echocardiography as a noninvasive method to assess central venous return, nine healthy volunteers were studied before and after isosorbide dinitrate given four times daily for 8 days. First dose isosorbide dinitrate led to a drop in heart rate and mean arterial pressure, and right ventricular inflow velocities decreased. With sustained treatment effects on systemic venous return remained unaltered, whereas reduction in heart rate and in mean arterial pressure was lost. Regarding this disappearing response as indicating a form of tolerance, venous hemodynamic nitrate effects were unaltered by development of tolerance on the arterial side.

Adult↗
PubMed1982

The forearm ischaemic work test--hazardous to McArdle patients?

A 57-year-old patient suffering from late-onset McArdle's disease developed myoglobinaemia, massive myoglobinuria and marked serum creatine kinase elevation subsequent to a routinely performed forearm ischaemic work test. Twenty hours after the test, enhancement of 99mTc methylene-diphosphonate activity was demonstrated exclusively in the tested forearm. It is concluded that the forearm ischaemic work test is potentially hazardous to McArdle patients, as it might induce myoglobinuria sufficient to result in acute myoglobinuric renal failure.

Exercise Test↗
PubMed1981

Increased ammonia production during forearm ischemic work test in McArdle's disease.

A patient with typical features of late onset McArdle's disease is described. During forearm ischemic work test the patient exhibited an exaggerated increase in ammonia release, largely exceeding normal values. It is suggested, that this is due to an activation of the myokinase/myoadenylate deaminase pathway. Besides lack of lactate release increased ammonia release during ischemia may be a typical feature of McArdle's disease.

Ammonia↗
PubMed1981

[Drug interactions with corticoids].

Corticosteroids, as far as they are not being used as endocrinological substitutes, are usually prescribed in combination therapy with other non-steroidal drugs in order to cut down on the well known side-effects of a steroid therapy. Most of the patients needing cortisone derivatives also require additional drugs to therapy other diseases of which they are suffering at the same time. Because of this fact, the possibility of drug interactions is indeed a great one. Even though, theoretically, these may be numerous, however, only a few are of practical relevancy. Caution is recommended when simultaneously giving corticosteroids and barbiturates, anticonvulsive agents, rifampicin, cholinesterase inhibitors, non-steroid antirheumatics, and last, but not least, saluretics and laxatives. Patients having low serum protein levels must also receive lower cortisone dosage.

Adrenal Cortex Hormones↗
PubMed1981

[Myoglobinuria in malabsorption after small bowel resection].

A patient with subtotal small bowel resection after mesenterial vein thrombosis presented with muscular weakness and pain. An increase in the activities of enzymes of muscular origin and of myoglobin in serum was found and myoglobinuria was detected. Muscle damage in this patient is attributed to electrolyte disturbances following extensive small bowel resection.

Aged↗
PubMed1981

[Myoglobinuric renal failure in hyperosmolar diabetic coma (author's transl)].

Acute rhabdomyolysis with myoglobinuric renal failure occurred in a 66-year-old woman who was in hyperosmolar non-ketotic diabetic coma. No previous description of such a case has been found. The clinical picture was characterized by the typical findings of hyperosmolar coma, in addition to excessive serum creatine kinase and myoglobin levels and massive myoglobinuria with acute renal failure. The rhabdomyolysis became fully manifest only under insulin treatment, possibly the result of insulin-induced hypophosphataemia, which seems to be of importance in the causation of the rhabdomyolysis.

Acute Kidney Injury↗
PubMed1981

[Elevated serum myoglobin in renal failure (author's transl)].

In 44 patients with chronic renal failure of varied etiology serum immunoreactive myoglobin was measured and compared to values obtained in patients with normal renal function. Irrespective of the underlying disease a highly significant linear correlation was found between serum immunoreactive myoglobin and serum creatinine concentration. In patients with serum creatinine concentrations above 550 mu mol/1 (6.2 mg%) serum myoglobin was as a rule elevated above the range found in the controls with normal renal function. This was also true in dialysis patients. These result demonstrate that serum myoglobin may only be used with restrictions in the diagnosis of myocardial infarction in patients suffering from advanced chronic renal failure.

Humans↗
PubMed1981

[Early prediction of infarct size by serial determination of serum myoglobin (author's transl)].

40 patients with acute myocardial infarction had serial determinations of CK, CKMB and an addition of serum myoglobin (SMb) by radioimmunoassay. In 10 patients with normal values on admission SMb rose earlier than CK and CKMB. In another 20 patients SMb was pathologically increased while CK and CKMB were normal and in 10 patients all parameters were elevated on admission. In all 40 patients SMb was significantly elevated in between 10 hrs after beginning of angina, and peak myoglobin occurred 10 hrs before CK and CKMB. In 10 patients peak SMb correlated with infarct size as determined by angiocardiography in the chronic stage (r = 0.863; p less than 0.01). Peak SMb also correlated with infarct size as estimated by CK release (r = 0.73; p less than 0.001). Thus determination of SMb is a sensitive method in diagnosing early myocardial infarction, and peak serum myoglobin allows early prediction of infarct size.

Acute Disease↗
PubMed1980

[Antirheumatics - Which to choose].

The vast amount of so-called antirheumatics that have flooded the pharmaceutical market in recent time makes it practically impossible for the physician to distinguish between positive and negative therapeutical effects of these drugs. We have therefore tried, based upon the pharmaco-dynamical and pharmaco-kinetical results as well as clinical experience, to give rational advice as to application of antirheumatic substances in general practice. It has shown, that as in all of the subdivisions of pharmatherapeutics the best therapy is to treat patients with only a small contingent of name drugs, whose side-effects and dangers are exactly known.

Anti-Inflammatory Agents↗