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Biomedical subjects

H Jonsson

Publications and source records attributed to H Jonsson.

At least 109 records · Page 6Linked to original sources
PubMed1988

The effect of age on clinical and serological manifestations in unselected patients with systemic lupus erythematosus.

In a unique series of 80 patients with systemic lupus erythematosus constituting all identified cases in a defined population, the effect of age, at onset and at diagnosis, on disease expression was examined. Contrary to current views, the incidence of the disease was similar among all age groups. The proportion of patients with serositis, secondary Sjögren's syndrome, and anti-SSA antibodies gradually increased with age, while that of cutaneous symptoms, antibodies to native DNA, and hypocomplementemia decreased. Serositis was common as the initial symptom in the elderly and serositis or musculoskeletal manifestations were the initial symptom in 88% of patients over 50 at onset of disease.

Adult↗
PubMed1988

Complement fixation by solid phase immune complexes. Reduced capacity in SLE sera.

We describe an ELISA for assessment of complement function based on the capacity of serum to support fixation of complement components to solid phase immune complexes (IC). Microplates were coated with aggregated bovine serum albumin (BSA) followed by rabbit anti-BSA IgG. The solid phase IC were reacted with human serum. The uptake of C3b, C4b and properdin was measured using biotinylated F(ab)2 antibodies to each of the proteins, avidin alkaline phosphatase, and paranitrophenyl phosphate. Serial samples obtained from 15 patients with systemic lupus erythematosus were investigated. Out of 72 sera, 24 showed a reduced capacity to support incorporation of C4b into solid phase IC. Thirty-one of the sera showed low C3b binding and 59 of the sera a reduced uptake of properdin. The incorporation into solid phase IC of C3b and C4b as well as of C3b and properdin were closely correlated at high disease activity. In general, patients with severe disease manifestations showed low values in the uptake assays. Judging from the results obtained by analysis of serial samples, the uptake of C3b, C4b and properdin, complement mediated solubilization of fluid phase IC and the concentrations of C1q binding IC were useful indicators of disease activity in the patients. The concentrations of circulating C4, C3 and properdin varied less consistently according to disease activity. The concentrations of serum properdin were never found to be low, which was in contrast to the finding of reduced properdin uptake by solid phase IC in most of the samples.

Adult↗
PubMed1987

Attempt at predicting paraphrenic outcome in young, first admitted schizophrenic patients.

A sample of 110 consecutive first admission young schizophrenic patients treated between 1964 and 1967 was rediagnosed in 1981. Among 92 survivors, 27 could be labelled as paraphrenics. From information available at inception 97 variables were coded covering such areas as personality, previous disturbances, age and type of onset, and symptoms around admission. Sixty-three out of 97 variables were hypothesized to differentiate, at admission, future paraphrenics from the rest of the sample. Paraphrenics were found to have had less contact disturbance, better self-esteem, less neurotic symptoms in adolescence and childhood, and less complaints of unhappiness when growing up. They had more regressive and paranoid symptoms at admission, were older at onset of the disease, which was more acute, more often connected with precipitating events, and confusion. Certain non-regressive symptoms such as brooding, anhedonia and concentration difficulties were less common. A discriminant analysis yielded a proportion of correct predictions = 0.64 (p less than 0.05). The results are in accordance with the theory of more favourable energetic and organizational capacity in paranoid schizophrenics as compared with non-paranoids.

Adult↗
PubMed1986

Patterns of self-destructive behaviour in schizophrenia.

Of 110 consecutive, young schizophrenic patients, 18 (16.4%) died during a follow-up period of 14-17 years from first admission. Fifteen of them met with a sudden death. Definite suicide was proven in 10 cases (9%). Suicide was associated with chronicity in course, social dependency, and lowered efficiency. Some type of warning was present in all suicide cases. The frequency of suicide thoughts and attempts was high in the whole material. Suicide attempts were associated with protracted non-regressive symptomatology, readmission to hospital, social intervention, and female sex. The disparity of characteristics between attempted suicide and definite suicide cases may partly be explained by the preponderance of women among the former and by the fact that only half of the suicidal deaths occurred when the frequency of attempts was at its peak. In attempted suicide in men their characteristics were compatible with those of the whole group, as well as with those of the suicide cases.

Adult↗
PubMed1986

Non-regressive schizophrenia: prediction of regressive course.

Regressive course during a 14-17 year follow-up in 54 non-regressive (pseudoneurotic, borderline, latent) schizophrenic subjects was predicted from about 100 variables studied on first admission. A significant prediction could not be achieved. This finding lends additional support to our previous interpretation that patients with a non-regressive syndrome are schizophrenics. A large number of them will run a typical schizophrenic course, but we are unable to predict from initial data who will do so. The few possibly predictive variables seemed to be of an unspecific, quantitative and longitudinal nature. They may act in a cumulative manner to increase the vulnerability to psychotic decompensation.

Borderline Personality Disorder↗
PubMed1986

Symptomatic secondary Sjögren's syndrome in patients with systemic lupus erythematosus (SLE). Relation to anti-SS-A and anti-SS-B autoantibodies.

The prevalence of symptomatic secondary Sjögren's syndrome in 66 patients with SLE recruited from a defined population in southern Sweden was 59%. In 26 patients (39%) the symptoms were mild and variable, related to disease activity, while in a smaller group (20%) the symptoms appeared to be constant. The latter patients had an increased frequency of thyroid disease and autoantibodies to SS-A. The patients in this group were older, but did not seem to differ in regard to other disease manifestations.

Antibodies, Anti-Idiotypic↗
PubMed1984

Prediction of outcome in schizophrenia.

Prediction of 5-8 year outcome from presenting symptoms and background data was attempted in a sample of 110 first-admitted schizophrenics. Correlations between outcome criteria and single predictors as well as factor analytically derived clusters of predictors were studied. A rather consistent pattern of symptom variables as well as personality and social variables was found to be predictive of outcome. 'Atypical' symptoms were associated with good prognosis while longitudinal variables indicative of 'high-risk personality', or duration and severity of illness, were related to bad prognosis. Overt psychotic symptoms usually gave no correlations with outcome. A discriminant analytical approach was also used to predict outcome from combinations of predictor variables. When all variables were used to predict a combined outcome score, a high accuracy was achieved.

Adult↗
PubMed1983

Differential evaluation of outcome in schizophrenia.

State of health, work and social relations functioning as outcome measures in 95 survivors out of 110 schizophrenic probands proved to be only moderately intercorrelated at follow-up 6-9 years after first hospital admission. Total sick-leave time was the only treatment measure mirroring combined outcome, while the hospital treatment variables were connected only to working and self-supporting ability. Among social competence data, only living in partnership, and producing children after falling ill were associated with a favourable outcome. Self-reports and simple judgements by near relatives in response to precise questions provided reliable information. Attitude questions were completely unrelated to outcome. Outcome did not vary with type of initial symptomatology (regressive/non-regressive) but long duration of regression meant an unfavourable outcome. A better outcome in women as to social competence, working ability and degree of psychopathology stresses the necessity of noting the sex composition of materials in prognostic investigations.

Adult↗
PubMedDate not supplied

Changes in the lipids of human articular cartilage with age.

Histochemical and chemical studies demonstrated a significant increase in the lipods of articular cartilage with advancing age. Triglycerides, cholesterol, and phospholipids were identified chemically and were shown by comparative staining procedures to be present in intracellular and extracellular lipids. The distribution and the composition of the extracellular lipids were interpreted as indicating that the extracellular lipids are of cellular origin. Glycolipids were extracted from cartilage of all ages and were shown to account for a portion of the increase in total lipid with age. Glycolipids extracted from aged cartilage were partially characterized. Cerebrosides, sulfatides, and gangliosides were detected. Glycolipids were estimated to comprise from 5 to 10% of the total lipid of articular cartilage. Arachidonic acid concentrations increased maredly with age in the surface of cartilage but were present in trace amounts in deep cartilage, demonstrating clear-cut differences in the levels as well as the location of this fatty acid precursor of the prostaglandins (PGE2 and PGF2alpha).

Adolescent↗
PubMedDate not supplied

'Aggressive' low grade lymphocytic lymphomas can be identified by flow cytometric S-phase determinations.

Forty-five patients with low grade non-Hodgkin's lymphomas were studied with respect to the fraction of S-phase cells in fresh tumour material by flow cytometric analysis. Patients with stage I lymphomas were treated with radiotherapy, patients with stage II-IV lymphomas with Prednimustine (Sterecyt). Patients with lymphocytic lymphomas of CLL type were only treated if they had symptoms. Median S-phase fraction in the samples was 2.0 per cent. A significantly shorter survival was found for patients with lymphocytic lymphomas with S-phase fractions > 2.0 per cent compared with cases showing lower S-phase fractions. No significant difference in survival was found in the subgroups of immunocytic or follicular and follicular/diffuse centroblastic/centrocytic lymphomas. In a Cox multivariate analysis, in which also age, constitutional symptoms, stage and morphology were included, the fraction of S-phase cells was found to be a statistically significant, prognostic parameter for low grade lymphomas, mainly due to the result in the subgroup of lymphocytic lymphomas.

Cell Cycle↗
PubMedDate not supplied

Development of two novel CYP-antibodies and their use in a PCB exposure experiment with Mytilus edulis.

In an attempt to learn more about the cytochrome P450 (CYP) system of mussels, we used protein databases and alignment software to extract highly conserved CYP sequences. From these alignments synthetic peptides were produced and used for rabbit immunisation, which yielded polyclonal antibodies against the CYP families 2 and 4. The antibodies were evaluated with Western Blot and ELISA assays, using digestive gland microsomal samples from the mussel Mytilus edulis. Western Blots revealed immunoreactions for both antibodies. The anti-CYP2 sequence rendered one major immunopositive protein of approximately 49 kDa size, and weak signals for proteins of approximately 41 and 56 kDa size. The anti-CYP4 sequence rendered two major bands of approximately 56 and 59 kDa size, and also a weak immunoreaction with a protein of approximately 43 kDa size. ELISA rendered only weak signals even with a 1:50 dilution of IgG-purified serum. A 10-day exposure to Aroclor 1254 did not appear to affect any of the immunopositive proteins, while total PCBs in soft bodies increased from 14-40 ng/g DW in controls to 373-638 ng/g DW in exposed mussels.

Amino Acid Sequence↗
PubMedDate not supplied

Hand radiology characteristics of patients carrying the T(303)M mutation in the gene for matrilin-3.

OBJECTIVE: To determine whether the recently described hand osteoarthritis (HOA)-associated T(303)M mutation in the gene for matrilin-3 (MATN3) is associated with specific radiological changes on hand radiographs. METHOD: Standard hand radiographs from 26 HOA patients carrying the T(303)M missense mutation in the MATN3 gene (T(303)M patients) were compared with those from 52 HOA controls matched for sex, age, and clinical disease severity. Two blinded readers scored the radiographs, using the Verbruggen-Veys anatomical scoring system for the interphalangeal and metacarpophalangeal joints and the OARSI atlas scoring system for the first carpometacarpal (CMC1) joints. A scoring system based on the latter was used for the scaphoid-trapezoid-trapezoideum (STT) joints. RESULTS: No particular distinguishing features were found in the T(303)M patients and the prevalence of erosive and cystic changes was similar to the control group. As a group, however, the T(303)M patients had more severe thumb-base affection, particularly in the STT joint. Thus, definite radiological OA in both CMC1 and STT joints and higher STT scores compared with CMC1 were significantly more common in patients carrying the T(303)M mutation. Radiological scores for joint-space narrowing (CMC1 and STT) and osteophytes (STT) were also significantly higher in the T(303)M patients. CONCLUSION: Patients carrying the T(303)M mutation in the gene for matrilin-3 express a form of HOA that is radiologically indistinguishable from idiopathic HOA in individual patients but they have more severe thumb-base involvement, particularly in the STT joint. This is the first described genetic mutation that is associated with a common form of osteoarthritis.

Adult↗
PubMedDate not supplied

Social support and the development of immune function in human immunodeficiency virus infection.

A psychosocial investigation offered to all human immunodeficiency virus (HIV)-infected men with moderately severe or severe hemophilia in Sweden was made in 1986. Most of these men had been infected in the years 1980 to 1984 and told about their infections in 1985. Forty-nine subjects had answered questions in regard to sources of emotional support in their life situation. Based on the responses to these questions a score of "availability of attachment" (AVAT) was calculated, and two groups of patients were identified: one with high AVAT and one with low AVAT scores. The subjects were followed with regard to the state of their immune system, as reflected by CD4 counts, until 1990. The results indicated that a low AVAT score in 1985 was associated with a significantly more rapid progressive deterioration in CD4 count during subsequent years. The mechanism behind this association is unknown. Several possible confounders were not studied. However, if the association between a poor AVAT score and rapid CD4 deterioration after HIV infection is replicated in other samples, it could be important to the future clinical care of HIV-infected subjects.

Adolescent↗