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Biomedical subjects

H Jensen

Publications and source records attributed to H Jensen.

At least 127 records · Page 7Linked to original sources

Evaluation of radiocardiographic methods for determination of cardiac output and right and left ventricular ejection fractions using a cardiac phantom.

Cardiac output and ejection fractions of the cardiac ventricles are valuable measures of cardiac function. Noninvasive radionuclide techniques for determination of these measures are based on analysis of different data: first passage low frequency, first passage high frequency and multigated equilibrium data. We have evaluated the principles of these methods using a dynamic cardiac phantom. Radiocardiographic determinations of cardiac output and right and left ventricular ejection fractions showed excellent correlation against true phantom values: r = 0.993 (p less than 0.001), r = 0.978 (p less than 0.01) and r = 0.943 (p less than 0.05), respectively. Thus, the findings of the present study demonstrate a high validity of current radiocardiographic measures of cardiac function.

Cardiac Output↗

Incidence of bilateral testicular germ cell cancer in Denmark, 1960-84: preliminary findings.

The incidence of a second primary testicular germ cell cancer in the contralateral testicle among 2338 men with a first primary testicular germ cell cancer diagnosed in the years 1960-79 in Denmark was established in this preliminary report. The material represents 83% of the total cohort followed until 31 December 1984. The relative risk for a patient with testicular cancer to get yet another testicular cancer was studied, taking into account the histology of the first primary testicular germ cell cancer. Based on fifty-eight nonsimultaneous contralateral testicular cancer cases and 19,995 'person-years at risk', the overall relative risk of invasive germ cell cancer in the contralateral testicle following a first germ cell testicular cancer was found to be 23.3 (95% confidence interval: 18-30). Among men with nonseminoma the risk was higher (relative risk = 27.5) than among men with seminomas (relative risk = 20.1). Overall, sixty-two (2.7%) patients developed a second cancer. In four of these patients bilateral tumours occurred simultaneously.

Denmark↗

Labor complicated by spontaneous emphysema.

Spontaneous subcutaneous and mediastinal emphysema is a rare but potentially dangerous complication of delivery. The condition was observed in a 24-year-old, small and slightly-built primipara after vaginal delivery of a large infant.

Adult↗

Determination of cardiac output by first passage radiocardiography: theoretical considerations and phantom studies.

Non-invasive determination of cardiac output by aid of precordial first passage radiocardiography may prove a useful tool in the management of cardiac disorders. The basic concepts of a method together with theoretical assumptions necessary for the clinical application of the method are described. The principle of the technique was tested in a cardiac phantom model with adjustable stroke volume and heart rate, in which background problems were avoided. First passage radiocardiography gave highly accurate cardiac output determinations compared with the 'true' phantom values, r = 0.998 (p less than 0.001).

Cardiac Output↗

Visual acuity in Danish school children.

The medical records of 8769 school children attending the 2nd-5th grades in the Municipality of Odense have been scrutinized with regard to visual acuity. 1216 children were subject to examination, of these 1034 were found to have reduced vision due to anomalies of refraction other causes. Bilateral reduction in vision of less than or equal to 6/18 was observed in 8 children corresponding to 0.09%. Unilateral reduction in sight of less than or equal to 6/12 (employed here as the definition of amblyopia) was seen in 1.07% of the children. This applied to 1.39% of the boys and 0.73% of the girls; the difference is statistically significant. The lower frequency of amblyopia as compared to earlier investigations is probably a consequence of better vision screening during preschool age.

Adolescent↗

Relationship of premorbid state of nutrition to endometrial carcinoma.

Women with endometrial cancer are often reported as being overweight. It is thus of some interest to examine a possible connection between body weight and development of cancer corporis uteri, since a positive result might be of significance in a preventive respect. A retrospective epidemiological study of 414 patients revealed a positive correlation between body weight and endometrial carcinoma. 73.4% of the patients were overweight and 55.8% were obese. The patients had a significantly greater absolute and relative weight than normal controls of corresponding age. There was a tendency for the patients to be taller than the controls. Endometrial carcinoma may have a hormonal etiology as a result of prolonged or increased estrogenic influence on the endometrium, possibly intensified by missing progesterone stimulation. As obesity contributes to an increased level of estrogen--androstenedione being converted into estrone in the fatty tissue--a hypothesis is advanced that the diet is of importance for the development of endometrial carcinoma, as dietary quantity and composition may influence the estrogen metabolism, and thus affect the endometrial mucosa.

Adenocarcinoma↗

Endometrial carcinoma. A retrospective, epidemiological study.

In a retrospective, epidemiological study of 414 patients with endometrial carcinoma, 73.4 percent were overweight and 55.8 percent were obese. The patients had a significantly greater absolute and relative weight than normal control subjects. A tendency was also apparent for height to be greater than in the controls. The patients had low fertility, early menarche and a tendency to late menopause, as well as a considerable premorbid consumption of estrogen preparations. Another characteristic of the patients was their low social class. The aetiology of endometrial carcinoma is presumably multifactorial. Long-term or increased estrogen stimulation of the endometrium plays a role, possibly potentiated by absence of progesterone influence. Obesity contributes to elevated estrogen level by the conversion of androstenedione to estrone in the fatty tissue. The diet depends on the social background and is significant for the development of obesity. Obesity, together with the amount and the composition of the food consumed, might predispose to endometrial cancer by elevated production of endogenous estrogen.

Adenocarcinoma↗