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Biomedical subjects

H Jacob

Publications and source records attributed to H Jacob.

At least 73 records · Page 4Linked to original sources
PubMed1976

[The neurobiology of the successive stages of life (author's transl)].

The neurobiological sciences deal with morphological, physiological, biochemical, and pharmacological investigations of neurobiological processes and mechanisms. In addition, they are interested in living organisms as action systems, with their forms of motion, types of behavior, and means of adapting to the environment. The topic "The Neurobiology of the Successive Stages of Life" covers the entire span of life, from the induction of the neural tube to senescence and death, i.e. the sum total of all continuous changes which are described by such terms as development, differentiation, specialization, individuation, functional maturity, and ageing. The following gives a survey from a special neurological-neuroanatomical point of view, it deals with the early development of prenatal activities, forms of movement, and refled differentiation cycles in regard to neurofibrillation, myelination, and cytological-cytoarchetectonic structures. Paul Yakovlev's and Peter Kuzmich Anokhin's interpretations of such selective morphological-functional maturation processes inherent in the system are discussed. There follows a brief survey of varying metabolic systems in close connection with the differentiation of nerve and glia cells and capillarization processes. The subject of early programmed cell death, nerve-cell degeneration, and heterotopia during the development, differentiation, and maturation of the central nervous system leads to a discussion of the likewise selective system-bound processes that take place during senescence of the central nervous system.

Adolescent↗
PubMed1974

Antiinflammatory effects of murine malignant cells.

Development of teratocarcinoma does not impair immunization of mice against Listeria monocytogenes. Endotoxin injection a short time before tumor cell inoculation allows the growth of teratocarcinoma in non syngenic mice despite immune stimulation. In contrast with this absence of impaired systematic immunity, teratocarcinoma cells were found to repulse macrophages in vitro. This effect on macrophages was also found with three other malignant cells and with trophoblast cells. In vivo, teratocarcinoma cells were found to impair local inflammation. These cells and other malignant cells are able to produce a compound(s) of molecular weight between 10(3) and 10(4), which prevents inflammatory reaction. These results suggest that mouse teratocarcinomas and other tumors by-pass the host immunological system of surveillance by at least two mechanisms: a direct toxic effect on macrophages and the release of an inhibitor of inflammation. The possible relations between these properties of malignant cells and physiological functions of trophoblast are discussed.

Animals↗