The completeness of molecular biology.
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Models, Biological↗
Biomedical subjects
H J Morowitz
Publications and source records attributed to H J Morowitz.
Dr. Mitzkin's mistake.
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Literature, Modern↗
Between history and physics.
Biology has traditionally occupied a middle ground between the determinism of classical physics and the uncertainties of history. These issues are analyzed with respect to statistical laws which are applied to the prebiotic domain and strategy laws which characterize evolutionary biology. The differences in approach between biology and physics are discussed in detail. The origin of life is discussed in the context of physical chemical laws. A scenario for biogenesis is presented in terms of known molecular hardware. Evolutionary biology is then examined with respect to the kinds of laws that are possible in a domain where thermal fluctuations (mutations) have macroscopic effects. Game theory is employed to demonstrate the kinds of theory appropriate to this historical domain. The transition point between physics and history is the origin and development of the code. This is discussed and it is concluded that we are not yet able to assign the code to either the deterministic domain or to the arena of history.
Animals↗
How E. coli got its name.
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Escherichia coli↗
Much ado about nothing.
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History, 18th Century↗
Phase separation, charge separation and biogenesis.
The current view of bioenergetics postulates transmembrane charge separation as a primary mechanism of energy storage and transformation. Using that bioenergetic view we examine possible methods of photon driven transduction in primordial vesicles. Two possible types of proton pumps are analyzed and a method of anaerobic photophosphorylation is discussed. Using these principles we theorize about the formation of prebiotic photochemical vesicles utilizing the same transmembrane energy conversions characteristic of contemporary cellular systems.
Anaerobiosis↗
The phenomenon of man.
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Biological Evolution↗