Biomedical subjects
Publications and source records attributed to H J Klein.
Explore the source record for details and available documents.
Diabur-test 5000, a new test strip for estimation of urinary glucose, was compared with the hexokinase glucose-6-phosphate dehydrogenase method in more than 2500 urine samples. By combination of two test ranges glucose concentrations of up to 5% can be detected by the strip test. After a reading time of 2 minutes, very precise estimation of urinary glucose is possible in eight steps from negative to 5%. False estimations of more than one color step virtually do not occur. Ketone bodies, salicylic acid and several antibiotics do not influence the test strip. Ascorbic acid shows a slight influence only in concentrations above 40 mg/dl. This influence disappears with glucose concentrations of more than 0.5%. Good correlation with the reference method, wide range of readings and simple handling make the test strip suited for the laboratory and particularly for self control of diabetic patients.
The efficacy of bezafibrate in the treatment of hyperlipoproteinaemia was investigated in a controlled therapeutic study and compared with "essential" phospholipids (EPL) and placebo. The investigation involved 120 patients, 87 trial protocols could be evaluated statistically. During pretreatment with bezafibrate for three months cholesterol, triglycerides and fasting blood sugar decreased significantly, HDL-cholesterol increased significantly. During continued treatment with bezafibrate the investigated parameters remained at their achieved levels, whereas with both EPL and placebo there was a renewed increase of cholesterol, triglycerides, fasting blood sugar and HbA1 and a decrease of HDL-cholesterol to values before bezafibrate treatment. There were no differences between placebo and EPL. Both bezafibrate and EPL were tolerated well.
With the application of neomycinsulfat (Nebacetin) during neurosurgical operations the authors observed an infection rate below 1%. The form of application is intracerebral, epidural or intramuscular depending on the operation itself, wound infections and serum concentrations of neomycinsulfat are reported separately.
Explore the source record for details and available documents.
The clinical and angiographic findings in a 23-year-old patient with hyperlipoproteinaemia type IV are described. The patient had suffered repeated, transitory attacks of focal cerebral ischaemia. During angiography, occlusion of a branch of the left middle cerebral artery occurred. This was followed by severe neurological deficit, which, however, recovered completely after three days. The pathogenesis of the angiographic findings and of this complication are discussed.
Explore the source record for details and available documents.
191 migraine patients reported previous allergic diseases, tendency to vertigo and collapse, attacks of tachycardia, blood coagulation disorders, surgically treated cysts and fibromas and inflammatory diseases of various organs significantly more frequently than a control group similar in age, sex and social standing (N equal to 150). 140 patients reported retrospectively on the efficacy and side effects of different drugs. Ergotamine preparations showed a significantly better effect than others. The shorter the untreated attack, the more effective the preparations appeared to be. The younger the patients the better the effect of Dihydergot for interval treatment of migraine. Acupuncture was not successful. 16% of the patients abused their drugs.
In our series of patients, blood lactate is investigated in type II-diabetics under sulfonylurea or sulfonylureabiguanid treatment. Under biguanides a statistically significant increase of blood lactate is found dose-dependent, but independent of the type of biguanides used.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The high incidence of consumption coagulopathy in active liver cirrhosis prompted us to introduce low-dosage heparin therapy (LDHT) in the management of this condition. An investigation was carried out on 109 patients with clinical and biochemical evidence of progressive liver cirrhosis, which was designed to evaluate whether in addition to basic LDHT, the administration of either vitamin K1, human fibrinogen or partial prothrombin complex (Prothromplex 500) enhanced the results obtained with LDHT alone. The normotest, PTT, thrombin coagulase activity, fibrinogen and platelet count were determined at regular intervals. A significant increase in fibrinogen and platelet count was obtained within 14 days of LDHT in about 75% of the patients and the consumption coagulopathy was halted. Additional treatment with vitamin K1 did not bring about any further increase in the prothrombin complex. Substitution therapy with factors II, IX, X and fibrinogen combined with LDHT brought the expected results. The results reported in the literature and the aims of, and indications for LDHT are discussed.
INTRODUCTION: People who spend their entire lives in highly industrialized regions are in danger of accumulating trace elements by inhalation as a result of the increased amounts of factory-produced smoke. In order to test the environmentally accumulated trace elements in lungs, lung samples of patients who lived their entire lives in the industrial area of Duisburg were compared with those of patients from the less industrialized areas of Cologne and surroundings. MATERIAL AND METHOD: Five patients were studied who lived in Duisburg and died at 50-68 years but not primarily as a result of lung diseases. From each patient five samples of the left lung were removed at autopsy. Lungs from 18 patients who died in Cologne were also examined. From each of the latter 2 samples were removed from the left lung. All samples were studied by means of neutron activation analysis and the following elements analysed: Co, Fe, Rb, Se, Cr, Cs, Sb, Sc, Zn and Al. The Al-concentration was analysed only in patients aged 50-68 years. RESULTS: The values of the non-essential Sc, Al and Cs and of the essential trace elements Co were found to be appreciably higher in the samples from Duisburg than in those from Cologne. Sc in the samples from the highly industrialized area was increased up to a factor of 100, Cs, Al and Co to a factor of 10. In the lungs of adults in Duisburg, aged 50-68 years, the concentration of Sc was more than 1,000 times greater than in lungs of children in Cologne, aged 0-10 years. In all samples from Duisburg, the rare element Eu was detectable by means of neutron activation analysis but could not be detected in a sample from Cologne. DISCUSSION: It is likely that the different uptakes of trace elements in the lungs depend on correspondingly different concentrations of the elements in the air. The extensive accumulation, especially of the non-essential elements, in the lungs should be an incentive to examine possible detrimental effects on human health in the future. The element Sc which was strikingly accumulated in the lungs and which can be easily measured by neutron activation analysis might be used as a standard for estimating the extent of environmental pollution.
In 80 patients suffering from liver cirrhosis and coagulation disorders a rapid and significant restitution of the disturbed coagulation system can be expected by a therapy with low doses of Heparin.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.