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Biomedical subjects

H Ippen

Publications and source records attributed to H Ippen.

At least 91 records · Page 5Linked to original sources
PubMed1979

[Allergic skin reactions in metallurgic industries (author's transl)].

The sensitizing properties of additives to cooling emulsions are reviewed. Presently the majority oft skin disorders due to cooling emulsions is of toxic and not of allergic origin. However, the introduction of new chemical substances either as substitutes of nitrites or for a more effective preservation may reverse this ratio especially if potent allergens are used unitentionally. In evaluating the advantage of a new additive its possible sensitizing properties has to be considered.

Dermatitis, Occupational↗
PubMed1979

[Acute axillary eczema caused by mercury compounds].

Not every axillary dermatitis is caused by an allergy against corresponding cosmetics (deodorants or anti-perspirants). This is shown in a 24-year-old man with an acute contact dermatitis in the left axilla. Sensitization probably developed against mercury salts due to the regular use of thermometers which were kept in a disinfecting solution containing phenylmercuric borate. The patient was in two hospitals for a check up before heart surgery and temperature was regularly measured in the left axilla. In both clincis phenylmercuric borate was used for desinfection of the thermometers. The sensitivity was proofed by positive patch tests.

Adult↗
PubMed1978

[Porphyria erythropoietica congenita Günther and chloroquine (author's transl)].

Treatment of a six-year-old boy with porphyria congenita (Günther) by small amounts of chloroquine was followed by a sharp but transient increase of the urinary excretion of porphyrins. Moreover, a nearly complete normalization of the previously observed rigidity of the erythrocytes occurred. With respect to the possibility that this elevated rigidity plays an important role for the typical hemolysis connected with this porphyria, the application of chloroquine could be of therapeutic value for this disease.

Child↗
PubMed1978

[Skin lesions in metal working (author's transl)].

The results of inspections of several workshops, of examinations of patients with skin lesions, and of skin tests made with different cutting fluids have been compiled in a survey of the factors that may enhance the development of skin lesions in metal working. Some recommendations how to reduce the relatively small number of skin lesions which may however accumulate, are made and directed to the manufacturers of these cutting liquids, their users, and the individual worker.

Dermatitis, Contact↗
PubMed1978

[Contact eczema caused by 1,4-bis-chloromethylbenzene].

Approximately 3 days of contact to 1,4-bis-chloromethylbenzene of a 24-year old chemistry student led to a bullous contact eczema within approx. 10 days. Patch tests with the substance proved definitely positive. A weak reaction also occurred with 1,4-bis-mercaptomethylbenzene, for the synthesis of which the chloromethyl derivative had been synthesized.

Adult↗
PubMed1978

The variability of the protection factors for sunscreening products.

The variation of the preotection factors for a sunscreening product as determined for different test subjects can be described by a logarithmic normal distribution. It is therefore more appropriate to use logarithmically transformed data for statistical analyses. By means of an analysis of variance it was shown that the influence of the subjects is responsible for only 12% of the total variance, whereas the remaining 88% is due to experimental error. Therefore, the difficulties in determining precise protection factors must be ascribed to deficiencies in the method itself. It was further concluded that correcting the protection factors with respect to a simultaneously measured reference preparation is not a means of improving the precision of the data. The reference substance, if it is included in every measuring series may, however, be used to check the long-term constancy of the method and to compare results from different laboratories.

Analysis of Variance↗
PubMed1978

Influence of a systemically administered aromatic retinoid (Ro 10-9359) on the light sensitivity.

The light sensitivity was determined on 14 psoriasis patients using two different light sources before, and after a three week period of systemic administration of 75 to 100 mg daily of the aromatic retinoid (ethyl ester of all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid, Ro 10-9359 [1]). The results indicate that with this therapy, the light sensitivity remains unchanged or even decreases; there is thus no contraindication to the simultaneous application of phototherapy and the systemic administration of this retinoic acid derivative.

Administration, Oral↗
PubMed1978

[Erosions caused by crystalline substances. Report of 3 iatrogenic cases].

Three examples demonstrate how therapeutics (potassium permanganate and silver nitrate), improperly applied, can lead to erosions the determination of which is difficult if a relatively low water solubility causes a prolonged latency between impact and perceptible consequence. This latency can be considerably extended by a slight development of subjective symptoms of such erosions. Two of the cases show that the prescription of granulated potassium permanganate requires an accurate information of the patient.

Adult↗
PubMed1977

[Treatment of photodermatoses with carotinoids (author's transl)].

39 patients were treated with carotinoids (beta-carotene alone or combined with canthaxanthine) with an oral dose of 50-150 mg/d, some of them for a period of several years. 23 of these were patients with porphyria (erythropoietic protoporphyria [EPP] 20, congenital erythropoietic porphyria 2, erythropoietic coproporphyria 1); 16 patients were suffering from various photodermatoses (solar urticaria 6, actinic reticuloid 5, UV-A intolerance 1, unclassified photodermatoses 4). Tolerance of the carotinoids was very good; no side effects were seen except for a yellow discoloration of the skin. In 19 of 20 EPP patients the result of the treatment was good, whereas no improvement was seen in the other kinds of porphyria. Of the 16 cases of photodermatoses not caused by porphyrinopathy, 6 responded to the therapy (solar urticaria 2, actinic reticuloid 2, UV-A intolerance 1, unclassified photodermatosis 1). Some cases showed great improvement as a result of the treatment.

Adolescent↗