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Biomedical subjects

H Ippen

Publications and source records attributed to H Ippen.

At least 73 records · Page 4Linked to original sources

[Burn scar carcinoma (author's transl)].

A patient suffering extensive burns on the back of the head from a heavy current accident in 1946 later had to undergo a craniotomy in this region. An ulcer later formed in the scar leading to a great defect of the cranial bone. 35 years after the accident a squamous cell carcinoma was established for the first time in the rim of the scar ulcer. The patient died in August 1981 of an acute coronary-artery insufficiency. In the autopsy an osteomalacia of the whole cranial bone after removal by operation of a horny squamous cell carcinoma, as well as a cerebral malacia were found. Based on the literature (31 references) on relations between burn scars and the later formation of carcinoma, the carcinoma was recognised as resulting from the accident.

Aged↗

[Phototoxic reaction to figs].

In several patients the effect of a phototoxic reaction to the juice of fresh figs (ficus carica) was observed as a striped pigmentation on the arms (after rubbing in the fruit juice followed by exposure to the sun), or as a patchy pigmentation of the face after eating fresh figs. Reference is made to the pathogenetic identity of this furocoumarin phototoxic reaction and the clinical transition of ficus dermatitis both to "Berloque dermatitis" (from the oil of types of citrus) and to bullous meadow dermatitis (from the juice of types of heracleum). Reference is also made to the similarity of the therapeutic furocoumarin reaction in PUVA therapy.

Adult↗

[Contact allergy to dexpanthenol (author's transl)].

During the testing for skin irritation of a sun protective and baby care lotion in epicutaneous tests over 24 hours, an eczematous test reaction appeared on a 30 year old physiotherapist. Testing of the single ingredients of both lotions showed the presence of contact allergy to Dexpanthenol.

Adult↗

[Hair growth, liver function and light sensitivity during oral retinoid therapy for psoriasis (author's transl)].

In a multicentre, cooperative study into the treatment of extensive psoriasis with a new aromatic retinoid (Ro 10--9359) trichogram, liver function tests and the light erythema threshold were investigated. In some of the patients hair loss occurred, usually in the fifth to eighth week after a total dose of 1.9 g retinoid. In all cases this improved an average of six weeks after dose reduction or cessation of treatment. The trichogram in 27 patients showed a diffuse toxic hair loss. In 70% the effluvium was telogenic, in 22% telogen-dystrophic. GPT, GOT, alkaline phosphatase and prothrombin index showed no significant alterations during retinoid treatment. However, in individual cases there was a rise in GOT and GPT up to 80 U/l. Furthermore there was a statistical tendency in rising bilirubin levels. Finally there was no evidence for an increase in light sensitivity after three weeks of retinoid treatment. Measurement of the erythema threshold showed rather more a reduction in light sensitivity under treatment.

Alanine Transaminase↗