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Biomedical subjects

H Huchzermeyer

Publications and source records attributed to H Huchzermeyer.

At least 55 records · Page 3Linked to original sources
PubMed1983

Single-drug and combined medication with cimetidine, antacids and pirenzepine in the prophylaxis of acute upper gastrointestinal bleeding.

For an analysis of the risk factors for stress bleeding, 24 risk factors selected from 202 clinical parameters were analysed, and their values determined in 586 medical and surgical intensive-care patients treated for at least six days between 1975 and 1980, who received no prophylactic medication. In 420 patients who received a prophylactic treatment with 800 mg or 1200 mg cimetidine, 2-hourly 30 ml antacids or 30 mg pirenzepine individually or in combination, the total risk scores were determined as the sum of the risk factors. This risk score served as the unit for comparison of the prophylaxis groups. Combined medication with two or three drugs proved to be significantly superior to treatment with either of the medicaments given alone.

Acute Disease↗
PubMed1983

[Does a stomach tube enhance regurgitation during general anaesthesia?].

The effect of a gastric tube on the competence of the lower esophageal sphincter was studied in 7 patients who underwent gastric resection. In 6 patients the maximal gastric volume until occurrence of regurgitation was lower in the presence of a gastric tube compared with the measurement without a tube. This shows the necessity to remove a gastric tube prior to induction of anaesthesia.

Adult↗
PubMed1982

The effect of pinaverium bromide (LA 1717) on the lower oesophageal sphincter.

An acute, double-blind study was carried out in 8 healthy male volunteers to investigate any effect of a new antispasmodic, pinaverium bromide, compared with placebo on the lower oesophageal sphincter. Manometric measurements showed no significant differences in resting pressures either after placebo or a therapeutic dose (200 mg) of pinaverium bromide, suggesting that the active drug does not cause any impairment of function of the lower oesophageal sphincter.

Adult↗
PubMed1981

[Indication and treatment with surgical therapy in primary non-epithelial cancers of the stomach].

The importance of surgical treatment in non-epithelial, primary malignant tumors of the stomach was investigated retrospectively in 27 cases. 85.2% of these tumors were non-Hodgkin lymphomas, 14.8% were leiomyosarcomas and Hodgkin's disease. There were no typical symptoms; those present resembled the symptoms of carcinomas and peptic ulcers. Most patients showed symptoms on average 6 months prior to diagnosis. Histocytological studies of endoscopic biopsies enabled a correct diagnosis to be made preoperatively in up to 75% of cases. The postoperative mortality was 14.8%; the 5-year survival rate was 56.2%. Thus the prognosis is significantly better than that of advanced cancer of the stomach.

Adult↗
PubMed1980

Laser coagulation in the upper GI tract: a preliminary light and scanning electron microscopic study.

Experimentally intact as well as artificially damaged mucosa of porcine stomach was endoscopically coagulated with Nd:YAG laser beams. Energy, intensity pattern, and time of application of the irradiation was varied and supracellular changes of the coagulated mucosa were subsequently investigated with the scanning electron microscope. The mucosa, damaged by laser beams, showed three typical zones: 1. a superficial, central carbonisation zone protected with a thin layer of coagulated mucus; 2. an elevated hyperemic ring with complete loss of superficial epithelium, but intact basement membrane and a blood clotting of the mucosal capillaries; 3. normal mucosa. After coagulating artificially induced bleeding of the mucosa the irradiated centre showed a deep depression with a carbonized surface. Two weeks later regeneration had occurred and there was complete reepithelialisation of the mucosa to about two-thirds of normal thickness.

Animals↗
PubMed1979

[The syndrome of acute fatty liver in pregnancy].

It is reported on the syndrome of the acute fatty liver of pregnancy and pointed out that early diagnosis, subsequent early termination of pregnancy and intensive treatment of complications, especially of hepatic and renal failure and disturbed blood clotting could reduce the mortality from almost 90 to 45 per cent within the recent years.

Acute Disease↗
PubMed1979

Follow-up study of chronic gastric erosions.

Chronic gastric erosions were detected with a frequency of 4.4% in 8,468 patients over the six year period from 1971 to 1977. The lesions were usually multiple, chain-like or clustered, along the greater curvature. The age group most often afflicted was the 50-60 year olds, and male predominance were three to one. In one-third of the cases, chronic erosions were found in combination with gastric or duodenal ulceration. Longterm observation of 64 patients over a period of four and a half years revealed no change in the condition in 50%, increase, decrease or complete disappearance of the lesions were found in the remaining 50%. In 10% chain-like multiple erosions developed into a persisting fold in the gastric mucosa. No evidence suggesting that erosive lesions lead to chronic ulceration or development of either polyps or malignancy within 4 1/2 years was recorded, nor was there any association with gastric protein loss.

Adolescent↗
PubMed1979

Endoscopic therapy of a congenital oesophageal stricture.

A sixteen months old girl with Down's-Syndrome suffered from congenital oesophageal membrane and segmental oesophageal stricture. In the neonatal period, two other associated malformations of the gastrointestinal tract (malrotation of gut and duodenal web) had been operated successfully. The first endoscopic examination of the eosophagus was performed at the age of sixteen months because of increasing dysphagia. A solid membrane in the lower part of the oesophagus was incised by diathermy. The associated segmental stenosis necessitated repeated bougienages. After this treatment the child developed well without clinical signs of dysphagia.

Down Syndrome↗
PubMed1979

[Endoscopic retrograde cholangiopancreaticography (ERCP) and percutaneous transhepatic cholangiography (PTC) in cholestatic syndromes of children and adolescents (author's transl)].

Conventional cholangiography had failed to establish a diagnosis in 5 children aged 6 weeks to 14 years and in 6 adolescents aged 14 to 18 years suffering from cholestasis; therefore endoscopic retrograde cholangiopancreaticography (ERCP) was performed, allowing to establish congenital biliary tract anomalies, cholelithiasis and benign obstruction of the extrahepatic biliary tract as causes of the cholestatic syndromes. Thus ERCP again turned out to be a valuable diagnostic procedure. Percutaneous transhepatic cholangiography (PTC) using the Chiba technique has not yet been applied in infancy to a great extent. Application of PTC however should be considered as well in cholestasis. It cannot yet be decided, if ERCP or PTC is to be prefered in neonatal cholestasis; further investigations are needed to clear up this point.

Adolescent↗
PubMed1979

[Preoperative detection of antrum mucosa in patients with peptic ulcer following gastric secretion -- indication for reintervention?].

In 6 of 23 patients with marginal ulcer after gastric resection (B II and Roux-Y anastomosis) a retained ("excluded") gastric antrum attached to the duodenal stump was detected by 99mTC pertechnetate scintiphotography; serum gastrin levels were normal in two of those cases. Resection has been abandoned as a treatment method, and transthoracic vagotomy is recommended for this disease.

Adult↗
PubMed1978

Response of basal and pentagastrin-stimulated gastric secretion and of serum gastrin to short- and long-term intravenous infusion of salmon calcitonin in hyperchlorhydric subjects.

In 23 volunteers with gastric hyperchlorhydria the effect of intravenous administration of salmon calcitonin (SMC) on basal (n = 11) and pentagastrin-stimulated gastric secretion (n = 12) and on immunoreactive serum gastrin (n = 11) was studied under various experimental conditions. SMC (0.075 microgram . kg(-1) . 2h(-1) and 0.3 microgram . kg(-1) . h(-1)) caused a statistically significant reduction of HCl output of 75% and 80% and of pepsin of 55% and 90%. Serum gastrin concentration showed a dose-dependent decrease of 17% and 31% respectively. Pentagastrin-stimulated acid secretion was moderately inhibited by short-term administration of SMC (0.15 and 0.30 microgram . kg(-1) . 30 min(-1)), the effect being confined to the period of application of the hormone. Long-term infusion of the smaller dose for 2 1/2 h induced a sustained decrease of HCl output by 55%. It is assumed that SMC inhibits gastric secretion mainly by interfering with the production or liberation, or both, of gastrin. Whether long-term administration of SMC has advantages over substances currently used as therapeutic inhibitors of gastric secretion, e.g. in gastroduodenal bleeding, has yet to be investigated.

Adult↗
PubMed1977

Endoscopic results in five patients with Crohn's disease of the esophagus.

In our experience with five cases of Crohn's disease of the esophagus, the endoscopic appearance has been demonstrated. Corresponding to the basic pathological changes, the findings are very different, but two stages may be differentiated: Stage I in which inflammatory changes predominate as a mild or more often erosive-ulcerative esophagitis. Stage II is a stenosing form similar to a peptic stenosis or to a stenosing tumor. The morphological changes are predominantly limited to the lower part of the esophagus with a tendency to extend to the proximal regions. The diagnosis may be established endoscopically only in special cases with shallow ulcerations within a normal mucosa or with cobble-stone relief which is usually seen in the colon. In all other cases, a specific macroscopical appearance of Crohn's disease of the esophagus does not exist and no specific differentiation is possible from other forms of esophagitis. Only by a combination of endoscopy, radiology and histology can the diagnosis be suspected. Guided biopsies are not able to confirm the diagnosis histologically. The exact diagnosis of Crohn's disease of the esophagus is only possible by histological examination of the resected esophagus.

Adult↗
PubMed1977

Dilatation of benign esophageal strictures by peroral fiberendoscopic bougienage.

A low risk procedure for dilation of esophageal strictures is peroral bougienage under direct endoscopic vision with a flexible fiberscope. First the stricture is inspected using the foreward lens of the fiberscope, and then dilated with conventional bougies according to its nature and size under direct visual control. In this paper we report on the treatment of 16 patients with inoperable advanced benign stenosis. In a total of 86 sittings an average of three bougienages each were performed without complication.

Dilatation↗