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Biomedical subjects

H Hosaka

Publications and source records attributed to H Hosaka.

At least 91 records · Page 5Linked to original sources
PubMed1983

Intravenous administration of sulpiride and heat sensation on the body surface.

Sulpiride was administered intravenously to 19 patients in a depressive or hallucinatory-paranoid state. The sensation of heat appeared characteristic as a side-effect of intravenous sulpiride when viewed in terms of frequency (arising in 13 of 19 cases), the site of occurrence (symmetrical, often on the ventral side in the upper half of the body), and the mode of occurrence (changes in the site in a short period of time). The fact that the mechanism of this heat sensation remains obscure makes caution advisable in using the drug.

Adolescent↗
PubMed1977

Dissociation of sleep stages between the two hemispheres in a case with unilateral thalamic tumor.

A case with an astrocytoma in the right basal ganglia, suspected of having originated from the posterior ventro-lateral part of the thalamus, without any clinical findings indicating severe internal hydrocephalus and cortical damaged, showed dissociation of sleep stages between the two hemispheres, i.e., the affected side always fell earlier into deeper stages of sleep and was more difficult to arouse by sonic stimulations than the other side. It is assumed that this bilateral dissociation with ipsilateral deactivation is due to the severe unilateral reduction of EEG activating influences from the brain stem and a possible functional damage to the interthalamic commissures. This finding can be explained sufficiently by recent theories based on experimental results in animals. The clinical value of this findings is also discussed in this paper.

Adolescent↗
PubMed1976

Studies on the relationship between the histological changes and liver cell function or plasma proteins in hepatic diseases.

Histological changes of liver biopsy specimens were compared with functioning liver cell mass estimated by an index, ICG capacity, and with plasma levels of various proteins, in 85 patients with liver diseases. IGC capacity was inversely proportional to the degrees of liver cell degeneration and lymphocyte infiltration in the portal tracts and parenchyma, in contrast to plasma disappearance rate of ICG (K), which was inversely proportional to the degrees of portal tract fibrosis and bridge formation. Among the plasma proteins synthesized in the liver, the plasma levels of prealbumin, and alpha1-acid glycoprotein showed the tendencies to decrease with the increase in the degrees of liver cell degeneration. The levels of ceruloplasmin, haptoglobin beta1A/C and transferrin were proportional to the degree of the degeneration. Plasma albumin had no correlation to any histological change. The plasma levels of gamma-globulin and IgG were both proportional to the degrees of portal tract fibrosis and bridge formation. IgM also paralleled to the degree of the fibrosis. The level of IgA was inversely proportional to the degree of liver cell swelling. It was concluded that quantitative estimations of some histological changes in the liver are valuable for the estimations of liver function and the grade of the diseases of the liver.

Blood Proteins↗
PubMed1976

Part I: abnormal patterns and physiological variations in magnetocardiograms.

Magnetocardiograms (MCGs) of six subjects with representative cardiac abnormalities and of one well-studied normal subject are compared with the 12-lead ECGs and VCGs of these subjects. The MCGs are recordings of the component of the magnetic vector which is normal to the skin, measured across the chest on a 5 cm X 5 am grid; an example is also presented of a sequence of instantaneous MCG maps. The heart abnormalities include myocardial infarction, angina pectoris, intraventricular conduction disturbances, and ventricular hypertrophy. The various MCG maps of the normal subject show MCG changes as a result of changes in body morphology (loss of weight), changes in the subject's position during recording, and changes as a result of exercise. They are presented as a basis for understanding some of the variability of MCG maps.

Angina Pectoris↗
PubMed1976

Part II: magnetic field produced by a current dipole.

To understand the MCG, electrical models of the heart must be used in which the basic building-block is usually the current dipole. The dipole's magnetic field is generally made up of two parts: 1. the contribution by the dipole element itself, which is mathematically simple; 2. the contribution by the current generated in the volume conductor by the dipole, which is complicated and depends on the boundaries; for special boundaries this contribution is zero to Bz, the component of magnetic field which is normal to the boundary. This applies to the boundaries of the semi-infinite volume conductor, the infinite slab, and the sphere. This property allows great simplification in solving the magnetic forward and inverse problems. Because of its importance, it is proven with electrolytic tank experiments. Based on this property, a method is presented for estimating the presence of those dipole combinations which produce a suppressed surface potential; it consists of a visual examination of an "arrow" display of Bz.

Electromagnetic Fields↗
PubMed1976

Part III: the effect of the torso boundaries on the magnetocardiogram.

The magnetic field produced by a current dipole is made up of two parts: the field from the dipole element, and from the current generated by the dipole in the volume conductor. It was previously shown for the semi-infinite volume conductor, infinite slab, and the sphere that the volume-current contribution is zero to the component of magnetic field which is normal to the boundary. The volume conductor in the form of the human torso is here investigated by computer simulation. Three different heart-torso models are used. The contribution to the normal field component (Bn) by the volume current (via the boundaries) and by the heart dipoles are computed. For comparison, the boundary contribution to the surface potential (V) is also computed. For Bn the three models yield a ratio of boundary to dipole contribution in the same range, with 0.28 as the average. Simple subtractions can make this ratio negligible. For V the equivalent ratio is somewhat greater. The arrow map, developed previously to display Bn over special surfaces, is shown to be valid for the human torso, for visually estimating the heart dipoles.

Electromagnetic Phenomena↗
PubMed1976

Part IV: visual determination of generators of the magnetocardiogram.

Previously it was shown that Bn, the component of the heart's magnetic field which is normal to the chest, is in large part produced directly by the generators in the heart; the volume-current (or boundary) contribution to Bn is relatively small. It was also shown that the distribution of Bn across the chest could be displayed as an arrow map which visually reveals the underlying dipole sources, in particular those dipole combinations which produce suppresed surface potentials but undiminished Bn. Arrow maps of two normal and one abnormal heart subject are here presented. The purpose is to demonstrate that the generators of the MCG can be coarsely estimated by visual inspection of these maps. The generators of the normal hearts are visually determined by comparing their arrow maps with those computed from the Cuffin-Selvester model. The generators of the abnormal heart are visually determined by trial-and-error, with the aid of a simple computing program. These examples are the first determinations, however approximate, of multi-dipole generators of the actual MCGs. Some possible new information is indicated.

Electromagnetic Phenomena↗