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Biomedical subjects

H Hoffmann

Publications and source records attributed to H Hoffmann.

At least 307 records · Page 17Linked to original sources
PubMed1976

[Age-dependence of catecholamine effects in man. IV. Effects of specific inhibitors on the lipolytic action of alpha and beta adrenergics].

In order to characterize age differences in the lipolytic effect of catecholamines on tests of subcutaneous adipose tissue of test persons aged from 0.1 to 10 years, from 20 to 40 years, and from 60 to 75 years the influence of propranolol, phentolamine and theophyllin on the release of glycerol by isoprenalin and adrenalin was investigated. Propranolol (10(8) and 10(5) mol/1) inhibits the lipolysis in the adipose tissue of all age groups stimulated by isoprenalin (10(6)and 10(5) mol/1). The following Ki-values were calculated: 2x10(6) mol/1in the tissue of adults, 0.5 x 10(6) mol/1 in the infantile adipose tissue, 0.2 X 10(6) mol/1 in the tissue of old persons. Phentolamine (10(5) mol/1) increases the lipolytic effect of adrenalin (10(5) mol/1), there are no age differences. Theophyllin (10 (2) mol/1) increases the release of glycerol induced by isoprenalin (10(5) mol/1) in infantile and adult adipose tissue, however, it has no influence on them in the adipose tissue of old man. The findings suggest the higher sensitivity of the fat cells of the ageing organism to beta-adrenergics underlies a higher affinity of the adrenergics to the specific beta-adrenoceptors in the cytoplasm membrane of the adipocytes. The more intensive lipid mobilization in old age by beta-adrenergics is explained by a low activity of the cAMP-phosphodiesterase of the fat cells and by the higher and possibly longer lasting increase of intracellular cAMP in this age group.

Adipose Tissue↗
PubMed1976

[The effect of etiroxate on serum lipids after myocardial infarction or in angina pectoris].

The lipid-lowering effect of etiroxate was studied in a double-blind cross-over trial comprising 183 patients with hyperlipoproteinaemia, most of whom had suffered myocardial infarction or exhibited confirmed coronary insufficiency. Etiroxate (40 mg daily) and placebo were administered for a period of 12 weeks each. In approximately 60% of the cases with Type IIa/IIb hyperlipoproteinaemia the cholesterol level fell by more than 10%. As regards the frequency of heart complaints, the consumption of nitroglycerine capsules, and heart rate, there were no statistically significant differences between the placebo and etiroxate phases. Thus etiroxate did not have any unfavourable cardiac side-effects in the patients of this study. No negative effects on hepatic and renal function or the peripheral blood count were observed.

Angina Pectoris↗
PubMed1976

[Age-dependence of catecholamine effect in man. III. Influence of alpha- and beta-adrenergic agents on the lipolysis in the adipose tissue in vitro].

With the help of subcutaneous adipose tissue performed on 0,1- to 10-, 20- to 40- and 60- to 75-year-old test persons the effect of isoprenalin, adrenalin and noradrenalin on the release of glycerol or the unesterified fatty acids was investigated. Independent on age the quantity of the isoprenalin-stimulated lipolysis increases with the size of the fatty acids of the incubated tissues. The specimens of adipose tissue used do not show any differences in the size of the adipocytes between the individual age groups. Amaximum release of glycerol is achieved in a concentration of the medium of 10(-5) mol/l (isopernalin) to 10(-4) mol/l (adrenalin). Isopernalin effects an altogether larger increase of lipolysis in the adipose tissue of the human being of old age in already smaller concentrations compared with other age groups. These findings refer to a higher affinity of adrenergic beta-receptors of the adipocytes in this age period, but also to possible age differences in the chain of lipolysis mediated by cAMP.

Adipose Tissue↗
PubMed1976

Treatment effectiveness as judged by successfully and unsuccessfully treated alcoholics.

Thirty-seven successfully and 46 unsuccessfully treated male alcoholics were asked to judge the effectiveness or ineffectiveness of six treatment methods routinely offered by a state hospital. For each treatment method, the total frequencies of judgments of most and least helpful, respectively, were as follows: detoxification (16%, 14%), lectures (16%, 20%), group therapy (54%, 7%), individual counseling (26%, 6%), work therapy (17%, 22%) and family therapy (13%, 14%). The two groups of subjects differed significantly in the frequencies of treatment methods judged to be "least helpful", but not in the frequencies of "most helpful" treatment. The similarity between the judgments of successfully and unsuccessfully treated alcoholics might reflect the positive effects of previous treatment in the unsuccessful group.

Adult↗