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Biomedical subjects

H Hoffmann

Publications and source records attributed to H Hoffmann.

At least 289 records · Page 16Linked to original sources
PubMed1979

[Pharmacological and toxicological study of turimycin].

Turimycin is characterised by low acute toxicity. Mean lethal doses for mouse and rat are 750 mg/kg body weight for intraperitoneal application of something in excess of 3,000 mg/kg for oral administration. The blood pressure of anaesthetised cats may be reduced by amounts depending on intravenous Turimycin doses (between 10 and 50 mg/kg). The hypotensive effect of Turimycin is attributable to its negative inotropic effect on the heart and its spasmolytic action on the unstriated muscles. Reversible reduction of urine and ion excretion of rat following intraperitoneal application of 50 mg/kg body weight of Turimycin is interpreted as a consequence of such action upon blood pressure. A preliminary study was conducted into dogs which had orally received daily Turimycin doses of 50 or 125 mg/kg body weight over twelve months. No substance-depending functional or morphological damage was recorded.

Animals↗
PubMed1979

Mortality of preoperative peritonitis in newborn infants without intestinal obstruction.

Within a period of 15 years 649 neonates were subjected to laparotomy; 60 (9%) of these patients died. Eighty-seven of the patients had a peritonitis already preoperatively without intestinal obstruction. Many of these were cases of ruptured omphaloceles or gastroschisis. In 17 infants a spontaneous intestinal perforation was the cause of the peritonitis. In 13 there was a preexisting meconium peritonitis. Seven children suffered from gangrenous intestine. Further causes for preoperative peritonitis were a complicated enteritis in 7 and a perforated appendix in 2 cases. Twenty-five or 29% of the children died. The highest mortality was found in children with ruptured omphalocele. It was 50% followed by gastroschisis with 36%. The mortality in patients with spontaneous intestinal perforation was rather similar, and the same high fatality rate was observed in infants with gangrenous intestine. In 28% of the children no cause for the peritonitis could be discovered. The high mortality rate is primarily due to the infants' bad general condition, i.e., low birth weight, prematurity and additional severe malformations.

Germany, West↗
PubMed1979

ATP contents and condensed configuration of rat liver mitochondria induced by rising ionic strength.

Experiments using shifts in ionic strength between 0.15 and 0.8 mol/l revealed that from 0.3 mol/l KCl onward toward higher concentration condensed mitochondria are observed. Parallel with increasing condensation, the ATP contents were found to rise up to 0.6 mol/l KCl. At 0.8 mol/l KCl already destroyed mitochondria were found. Also, at this concentration of KCl, ATP contents did not rise any longer. The SH reagent 2-mercaptopropionylglycine was effective at about physiological ionic strength only. Up to concentrations of 0.6 mol/l KCl H+/O ratios were not different from the controls at physiological ionic strength, but the effect of valinomycin was effectively reduced by high concentrations of KCl. It is suggested that condensation of mitochondrial structure is correlated with increases in ATP content.

Adenosine Triphosphate↗
PubMed1978

Intellectual functioning in lobotomized and non-lobotomized long term chronic schizophrenic patients.

Administered the WAIS routinely to 28 long term hospitalized chronic schizophrenic patients who had a bilateral prefrontal lobotomy during the years between 1948 and 1954 and 28 of their non-lobotomized counterparts matched on appropriate demographic characteristics. No statistically significant t-score differences between group means were demonstrated on any of the 11 subtests or three scale IQs.

Chronic Disease↗
PubMed1978

Toxicological studies on a new veterinary antibiotic turimycin.

Turimycin is a fermentation product ofStreptomyces hydroscopicus (DDR W-Patent-Nr. 84 450). It is highly active in vitro against a range of mycoplasma species and gram-positive bacteria. The acute toxicity was determined in mice, rats and dogs. In mice and rats LD50 values ranged from 750 mg/kg intraperitoneally to higher than 3000 mg/kg orally. In a chronic study on dogs oral doseas of 50 nad 125 mg/kg Turimycin were given daily in capsules for 12 months. The results showed no functional or morphological differences between treated and control animals.

Animals↗
PubMed1978

ATP contents and structure of rat liver mitochondria in the presence of 2-mercaptopropionylglycine.

2-Mercaptopropionylglycine was found to be efficient in the treatment of chronic hepatitis. Interest was focussed on the possible mode of action of that reagent at the subcellular level. ATP contents in mitochondria were increased after anaerobic preincubation and after addition of ADP and 2-mercaptopropionylglycine. Concomitantly, we found an increase in condensed configuration of mitochondria. If the reagent was added before ATP-Mg2+ (ADP) the mitochondrial structure was well preserved, though, throughout of orthodox configuration. In comparison the control specimens were grossly swollen. It is proposed that the reagent may act at the level of mitochondrial energy coupling.

Adenosine Triphosphate↗