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Biomedical subjects

H Hess

Publications and source records attributed to H Hess.

At least 91 records · Page 5Linked to original sources
PubMed1981

[Acute effects of low carbon monoxide concentrations on blood rheology, platelet fuction, and the arterial wall in the minipig (author's transl)].

While investigating the initial effects of low carbon monoxide concentrations on haemorheology and the arterial wall, minipigs were exposed to CO-air mixtures with 160, 185, and 420ppm CO. The daily exposure time was 4h. Exposure to 160 and 185 ppm CO led to a significant increase of platelet aggregation. Four hundred twenty parts per million CO caused an increase in haematocrit, blood and plasma viscosity, and in platelet aggregation. When examined by light microscopy, there were no changes in the arterial wall, whereas scanning electron-microscopic examinations revealed adhesions of shape-changed platelets on the arterial endothelium in some cases already after a single 4-h exposure to 160 or 185 ppm CO. After 4 x 4-h exposures to 420ppm CO there were mixed microthrombi on the arterial endothelium. According to preliminary transmission electron-microscopic studies these adhesions of platelets and also adhesions of mononuclear elements can always be related to foci of degeneration in the endothelial cells. These examinations showed that low concentrations of carbon monoxide can cause both haemorheological and morphological changes in the arterial wall. The further development of these changes under chronic CO exposure and a possible significance of the environmental hygiene beyond cigarette smoking has to be clarified by long-term experiments.

Animals↗
PubMed1981

[Interactions between vessel wall and blood and their role in developmental and therapy of arterial perfusion disorders (author's transl)].

The dynamic balance between the vessel wall and the systems of the platelets, of coagulation and of the fibrinolysis, termed vessel wall-blood homoiostasis, can be altered in a physiologically suitable way as well as pathologically. A disturbance of the vessel wall-blood homoiostasis is considered the key process of the pathogenesis of all obliterating angiopathies. This view can explain why different risk factors may lead to the same picture of obliterative arteriosclerosis. From this point of view practical consequences for the treatment arise which may - under most favorable circumstances - render a restitution and integrum possible or at least a regression of obliterative processes.

Arteriosclerosis↗
PubMed1980

[Eighteen years' experience of thrombolytic therapy with streptokinase (author's transl)].

18 years clinical experience with thrombolytic therapy has shown that venous and arterial thrombotic occlusions which persist not only for a few days but also for weeks and 2 to 4 months can be dissolved in about 60-70% of the cases by intravenous infusion of streptokinase. Although this treatment is one of the great break-throughs of internal medicine in this century it is not yet in general use. The reason for this is that the risk of a deleterious bleeding is difficult to assess. This and also the numerous contraindications can be diminished by direct infiltration of an intravasal clot with a relatively small amount of streptokinase through a catheter.

Arteriosclerosis↗
PubMed1980

[Low dose thrombolytic treatment for revascularisation in arterial occlusion (author's transl)].

Acute and subacute arterial occlusions of between 4.5 and 29 cm long could be dissolved in 11 patients by infiltration of small amounts (4000 to 110 000 U) of streptokinase or urokinase directly into the thrombus using a catheter. Use of a Grüntzig catheter enabled dilatation of possible stenoses during the same session. In 3 femoro-popliteal obliterations where lysis and catheter dilatation did not lead to sufficiently patent lumina occlusion recurred. In 3 patients with wide-ranging obliteration of the femoral, popliteal and almost all the arteries of the calf almost complete revascularisation could be achieved. Only transient slight side effects of lysis and coagulation disturbances were observed systemically. For prophylaxis of reobliteration platelet aggregation inhibitors are given for pre- and long-term aftercare.

Adolescent↗
PubMed1980

[Controlled, double blind study of a possible interaction between acemetacin and a concomitant anticoagulant therapy].

In a controlled double blind study, 20 patients undergoing long-term anticoagulant therapy with phenprocoumon received [1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetoxy]acetic acid (acemetacin, TV 1322, Rantudil) concomitantly to establish whether there was any risk of an interaction. Neither the placebo dose nor the concomitant medication with 3 x 60 mg acemetacin had any statistically important influence on thromboplastin value, fibrinogen, phenprocoumon consumption or platelet aggregation. Accordingly, no clinically relevant interaction is to be expected by the concomitant therapy with 3 x 60 mg acemetacin/d and phenprocoumon, or in all probability, with any coumarin compound.

4-Hydroxycoumarins↗
PubMed1980

How often does peptic ulcer produce "typical" ulcer symptoms?

Subjective symptoms of 876 hospitalized patients who underwent upper fiber-panendoscopy were evaluated in a prospective study. Ulcer-like symptoms were defined as pain-like discomfort with a regular food-related rhythm. These symptoms indicate ulcer disease with high specificity (96%) but low sensitivity (28%). In particular old patients with second disease rarely have ulcer-like symptoms. In spite of their high specificity, however, ulcer-like symptoms are not proof of active ulceration. Patients with scars but no ulcers may also have ulcer-like symptoms.

Aged↗
PubMed1980

[Changes in the relation between therapist and group in the phases of intended dynamic group psychotherapy].

The progress of a group under intended dynamic direction was recorded over a period of 65 hours on the basis of interaction frequencies and directions as well as interaction contents and styles. It could be demonstrated that by means of this relatively simple or global approach an adequate and sufficiently sensitive picture of the therapist/patient activities and their phase-specific change could be reflected. On the basis of an example of a cohesive group, the change in significance of the therapist postulated in our conception and the interaction process between group, therapist and patient could be confirmed. The data obtained for the individual hours have been condensed for a demonstration of the phase-typical course.

Communication↗
PubMed1979

[Acute and subacute acral ischemia syndromes (author's transl)].

Acute and subacute acral ischemia syndromes must be carefully distinguished from chronic intermittent acral disturbances of circulation because of the differences in the genesis, in the clinical picture and in the treatment. Vasoconstriction caused by cold or emotion and which disappears on warming is the principal feature of the chronic intermittent syndromes. Prestasis and stasis are the basis of the ischemia of acute and subacute syndromes, which cannot be relieved by warmth. Vasodilation measures have no effect, whereas the circulation can be restored by the improvement of the fluidity and the flow conditions of the blood.

Acute Disease↗
PubMed1979

[Fiber endoscopy and radiology in stomach ulcer, stomach neoplasms and hiatal hernia: questions, timing and value].

In 306 patients, fiberpanendoscopy and radiology were performed within a time interval of 7 days or less. In 196 cases, radiology was performed before endoscopy and in 110 cases after endoscopy. In cases with histologically unproven divergent findings, follow-up studies were performed. In the diagnosis of gastric ulcer and gastric cancer, endoscopy with biopsy was more accurate than radiology. In the diagnosis of hiatal hernia, radiology was more accurate. Important additional findings difficult or impossible to observe with endoscopy were present in 36% of the radiological examinations. Thus, the first examination should be endoscopy when ulcer or carcinoma is suspected. In patients with uncharacteristic epigastric symptoms, radiology should be performed first.

Duodenum↗