[A new liver function test using the asialoglycoprotein-receptor system on the liver cell membrane: II. Quantitative evaluation of labeled neoglycoprotein clearance].
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
H Hazama
Publications and source records attributed to H Hazama.
[A new liver function test using the asialoglycoprotein-receptor system on the liver cell membrane: III. Evaluation of its usefulness by a liver function test using Tc-99m-neoglycoprotein].
Explore the source record for details and available documents.
Albumins↗
R-R intervals of ECG in depression.
ECG measurements of consecutive 100 R-R intervals were done on depressive patients. The patient group presented lower mean values for coefficients of variation (CV) at each generation than the control group (normal subjects); the differences were significant especially for the subjects 40 to 49 years of age (P less than 0.05) and for those 60 to 69 years of age (P less than 0.01). These results can probably be regarded as a significant and objective index of autonomic disturbances in depression.
Adult↗
[Pressure sore and thermal blanket injury following a long surgical procedure].
Explore the source record for details and available documents.
Anesthesia, General↗
Double termination of the alimentary tract in females: a report of 12 cases and a literature review.
Twelve female infants with double termination of the alimentary tract were reported. One patient had a high rectovaginal fistula, but in the other 11 cases the tract opened into the bowel uniformly at the level of the levator ani (anorectal-vestibular fistula). In these patients, diagnosis of the anatomical level of the fistula was made definitely with our radiological technique. Excision of not only the fistulous tract but also the anterior half of the rectum below the fistula is essential to achieve a cure without recurrence. The pathogenesis of this condition is discussed and the pertinent literature reviewed.
Anal Canal↗
Antipsychotic and prophylactic effects of acetazolamide (Diamox) on atypical psychosis.
We investigated the antipsychotic and prophylactic effects of acetazolamide (Diamox) on atypical psychosis. Acetazolamide was given to 30 patients: Type I, puberal periodic psychosis, a psychosis whose onset occurs during the period of puberty and which appears repetitively with psychosis-like condition at about the same interval as the menstrual cycle (6 cases); Type II, a) presenile atypical psychosis which initially appears in patients in their 20s or 30s accompanied by manic-depressive cycles and shows acute confusional and dreamy states in the presenile period, incurable cases (7), b) atypical psychosis, in the narrow sense, cases which show acute hallucination, delusion, confusional and dreamy states accompanied by affective symptoms (8 cases); Type III, repetitively the atypical manic and depressive states, and atypical manic-depressive psychosis, and transient changes in consciousness, refractory cases (2); Type IV, atypical schizophrenia, which is considered to be schizophrenia but shows the abnormalities in electroencephalogram and emotional disorders (7 cases). Among these cases, some extent of the therapeutic effects of acetazolamide (500-1,000 mg/day) was obtained in about 70%. The high therapeutic effects were particularly observed in Types I, II and III. It was less effective against atypical schizophrenia. Acetazolamide showed the effectiveness in 10 cases out of 13 cases to which lithium carbonate and carbamazepine were ineffective. The high therapeutic effects of acetazolamide were shown in the cases whose symptoms were aggravated at the interval of the menstrual cycle. No correlation was observed between the electroencephalographic abnormalities and the therapeutic effects. In addition, the prophylactic effects of acetazolamide on the periodic crisis were observed in 9 cases. From these results, acetazolamide was considered to have the antipsychotic and prophylactic effects on atypical psychosis. Since side effects due to acetazolamide were rarely observed, the present drug was considered to have a high safety margin.
Acetazolamide↗
Influence of long-term administration of anticonvulsants on human somatic chromosomes. Relationships of chromosome aberrations to plasma concentration, dosage and duration of anticonvulsants.
Chromosomal aberrations of 16 patients who have taken anticonvulsants for a long time were examined, and the following results were obtained. (1) There was no definite relation between the dosage of anticonvulsants and the incidence of abnormal cells, but positive correlation was recognized between the plasma concentration of the agents and the incidence of abnormal cells. (2) A significant correlation was recognized between the duration of administration and the incidence of abnormal cells. (3) The mean duration of drug administration was 16.9 years, with the incidence of abnormal cells of more than 15% in a group of 12 abnormal female subjects, and 8.1 years with an incidence of abnormal cells of less than 15% in a group of 9 normal subjects. (4) Morphological chromosome aberrations observed were mostly gaps and breaks. Any increase of exchange-type aberration was not recognized. It is conceivable that plasma factors might be more significant than the direct action from drugs as a mechanism of chromosome aberration. We speculate about the effects of lymphocyte chromosome aberration on living bodies, and the necessity of chromosome examination for the patients on long-term anticonvulsant therapy.
Adolescent↗
Hyperasialoglycoproteinemia in patients with chronic liver diseases and/or liver cell carcinoma. Asialoglycoprotein receptor in cirrhosis and liver cell carcinoma.
The pathogenesis of hyperasialoglycoproteinemia in cirrhosis and liver cell carcinoma was investigated by measuring the amount of asialoglycoprotein receptor in hepatic tissues from 30 patients with either cirrhosis or a malignancy. The asialoglycoprotein receptor activity in the cirrhotic liver was 770 +/- 423 U/g liver, i.e., 28% of the control value (2770 +/- 731 U/g liver). Receptor activity was negligible in tissues from patients with either liver cell carcinoma or metastatic tumor. The receptor levels in noncirrhotic and cirrhotic tissues in close proximity to liver cell carcinoma were 2281 +/- 659 and 1134 +/- 473 U/g liver, respectively. There was a close correlation between serum asialoglycoprotein levels and the size of the tumor mass in patients with liver cell carcinoma. Our results suggest that decreases in the asialoglycoprotein receptor levels may lead to an accumulation of serum asialoglycoproteins in patients with cirrhosis or liver cell carcinoma, or both.
Asialoglycoprotein Receptor↗
Surgical management of piriform sinus fistula.
Four cases of acute cervical abscess resulting from infection through the left piriform sinus fistula are described. The fistula seems to be related to the cause of infection in many of previously reported cases of acute suppurative thyroiditis or "recurrent lateral cervical fistula." Complete removal of the fistula is essential to a permanent cure, and the guide of a Fogarty catheter through the fistula is useful at operation for patients with repeated infection.
Abscess↗
Age differences in effects on blood pressure, flicker fusion frequency, salivation and pharmacokinetics of single oral doses of dothiepin and amitriptyline.
Blood pressure, critical flicker fusion frequency (CFF), salivary flow rate and pharmacokinetics were compared in 7 young healthy volunteers (average age: 22.7 years) and in 7 elderly healthy volunteers (average age: 70.6 years) after single oral doses of the antidepressants dothiepin (DP) 25 mg and amitriptyline (AMP) 25 mg. Systolic blood pressure fell further and the reduction lasted longer in the elderly than in the young after both drugs. The decrease in CFF after AMP 25 mg, and the reduction in salivary flow rate after either DP 25 mg or AMP 25 mg were larger in the elderly than in the young. Plasma levels, T1/2 and Cl of both drugs in the elderly were also higher, longer and smaller, respectively, in the elderly. Clearance was found to be reduced in the elderly. More cautions dosage regimens of these drug should be considered for elderly patients.
Adult↗
Regional inhibition of monoamine oxidase activity by administration of clorgyline in rat brain.
The inhibiting effect of monoamine oxidase (MAO) activities towards 5-hydroxytryptamine, dopamine and beta-phenylethylamine by an acute and chronic administration of clorgyline was investigated in five locations of the rat brain. Inhibiting the percentage distributed unevenly in each hypothalamic nucleus and in the circumventricular areas, except the median eminence, the percentages were significantly low as compared with the hypothalamic lateral nucleus. A significant percentage of inhibition for type B MAO towards beta-phenylethylamine was noticed in the chronically administered group. In conclusion, the MAO-inhibiting effect of clorgyline administered intraperitoneally was unevenly distributed in the discrete brain nuclei and the regional difference depended upon the dose and the duration of the clorgyline administration.
Animals↗
Influence of single doses of dothiepin and amitriptyline on physiological measures and psychomotor performance in normal young and elderly volunteers.
The subjects were 14 (7 young and 7 elderly) men. Self-rating, and physiological and psychological measurements were applied, and experiments were performed 24 h after drug administrations. 25 mg dothiepin hydrochloride (DP) decreased critical flicker frequency less than 25 mg AMP in both age groups. 25 mg DP reduced whole mouth salivary rates less than 25 mg AMP, especially in the young subjects. 25 mg DP decreased diastolic blood pressure more than 25 mg AMP. Systolic blood pressure (after 25 mg DP and 25 mg AMP) and whole mouth salivary rates (after 25 mg AMP) were affected more intensely in the elderly than in the young volunteers.
Adult↗
Long-term prophylactic effects of carbamazepine in affective disorder.
The prophylactic effects of carbamazepine (CBZP) were studied in 32 patients with affective disorder who were receiving long-term therapy with CBZP. Complete inhibition of both manic and depressive episodes was observed in four cases, reduced incidence of episodes or decreased intensity of symptoms in twenty, and no change in eight. CBZP was significantly more effective in cases with an onset before the age of 20, and subjects showing a continuous pattern of alternating episodes responded better than those with a more intermittent history of mania and depression. Where CBZP had an effect it was generally apparent soon after therapy started. These results suggest that in some cases CBZP is an agent suitable for long-term continuous prophylactic therapy in manic-depressive disorder.
Adult↗
[Serum myoglobin value during enflurane anesthesia].
Explore the source record for details and available documents.
Adolescent↗
Computerized tomography of the brain in manic-depressive patients--a controlled study.
A computerized tomography (CT) of the brain was carried out on 40 manic-depressive patients and 40 controls in order to study the organic characteristics of the brain in manic-depressive psychosis. In the age group of 49 years and below, the left septum-caudate distance (LSC) showed a lower value in the manic-depressive group, but the other measurements for the ventricular system did not differ between both groups. The age group of 50 and over revealed a significant enlargement of maximum width of the interhemispheric fissure (IF) and maximum width between the sylvian fissure and inner skull (SFIS) in the manic-depressive group compared with the controls. The tendency to an enlargement of the third ventricle (HIV) and maximum width of the right anterior horn (RAH) was also seen in the manic-depressive patients. Cortical atrophy tended to appear in the temporal and occipital lobes earlier in the manic-depressive group than in the controls. The patients showing a cerebral asymmetry of the hemisphere in the manic-depressive group tended to show a reversed cerebral asymmetry.
Adolescent↗
A preliminary double-blind study on the efficacy of carbamazepine in prophylaxis of manic-depressive illness.
A preliminary double-blind controlled study on the prophylactic effect of carbamazepine on recurrent manic-depressive psychotics was conducted with 22 patients using an inert placebo in ten subjects as a control drug. Carbamazepine in the dosage of 200-600 mg was administered for 1 year. Among the 22 carbamazepine subjects, carbamazepine was found to be effective in 60% of the cases and inert placebo in 22.2% (U-test, P less than 0.10). It is suggested that carbamazepine is a useful drug for the prophylaxis of manic-depressive illness.
Adolescent↗
Computerized tomography of the brain in schizophrenic patients. A controlled study.
Computer tomography (CT) of the brain was carried out in 49 schizophrenic patients and 38 controls in order to study the organic characteristics of the brain in schizophrenia. Between the schizophrenic and control groups aged 21 to 40 years, there was no marked difference in ventricular size or cortical atrophy. In the groups aged 41 to 60 years, however, enlargement of the ventricular system and cortical atrophy were highly significant in the schizophrenic group. Positive correlation was observed (P less than 0.05) between enlargement of the third ventricle and duration of illness. There was a high frequency of cortical atrophy in the frontal and temporal lobes in the schizophrenic group.
Adult↗
Effects of long-term administration of anticonvulsant drugs on chromosomes in man.
Effects of long=term administration of anticonvulsant drugs on chromosomes in epileptic mothers and their children were examined. Specimens from peripheral lymphocytes were prepared by incubation for 3 days and colchicine treatment. Results obtained were as follows: (1) The incidence of abnormal cells in epileptic mother group over 9 years of drug administration was significantly higher than in the group below 9 years. (2) Most of chromosome abnormalities found in subjects were of comparatively simple morphological aberrations such as gaps or breaks. The incidence of the chromosome-type abnormalities was significantly higher in the patient group than in the control group. (3) Chromosome abnormality of children showed a positive correlation with that of mothers but was not significant. (4) The incidence of chromosome abnormality in children was reduced along with aging. (5) These observations could be interpreted to suggest that chromosome abnormality appearing in children born from epileptic mothers under drug therapy was probably formed by direct effects of anticonvulsant drugs on the fetal hematopoietic system.
Adult↗