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H Höffken

Publications and source records attributed to H Höffken.

At least 55 records · Page 3Linked to original sources
PubMed1982

[The primary non-Hodgkin lymphoma of the mammary gland].

Basing on an observation made by the authors, the article describes the diagnostic and therapeutic criteria in primary non-Hodgkin lymphoma of the mamma. Despite high malignancy, especially of the lymphoblastic-centroblastic lymphoma and of the immunoblastic lymphoma (Stein, 1974), permanent healing can be achieved via early surgical treatment and subsequent radiotherapy. In the case under discussion, the same tumour reappeared in the contralateral breast after an interval of five years. Since it was possible to exclude a generalisation, it must be assumed that the patient in question had a primary non-Hodgkin lymphoma of the immunoblastic type in both mammae after a period of five years.

Breast Neoplasms↗
PubMed1982

[Diagnosis and treatment of uterine sarcoma].

A group of 54 patients with uterine sarcomata is reviewed. The diagnosis, the pathological anatomy, the treatment and the prognosis of this rare disease which only comprises between 2-4% of all malignant tumours of the uterus is described. Special attention is directed to the tumours of so-called low grade malignancy, regarding their clinical and prognostic aspects in relationship to their morphology and biological potency. The discussion of the treatment centered around the desirability of additional chemotherapy. The answers to the numerous questions in this group of tumours can only be obtained by prospective collaborative studies of randomized groups of patients.

Adult↗
PubMed1982

[Conditions of metastatic spread of endometrial cancer: analysis of autopsy findings and clinical data].

Among 263 patients who suffered from endometrial carcinoma and died of their disease or unrelated causes autopsies showed metastases or recurrences in 165 cases. The conditions for metastatic spread were analysed from the morphological parameters of the tumour. The incidence and localization of above all the lymph node metastases are closely correlated to the grading and the depth of invasion (I 0 to I 3/3) of the primary tumour. The incidence of pelvic lymph node metastases is 8.7% at an invasion depth I 1/3,33% at an invasion depth of I 3/3 of the myometrium. Tumours with the invasion depth I 1/3 show metastases in the para-aortic lymph nodes in 17.3% and at the invasion depth I 3/3 in 50% of the cases. At an invasion depth of I 3/3 17% had exclusively para-aortic lymph node metastases. Pelvic lymph node metastases were found in tumours of the grading G 1 in 5.7% of the cases, in grading G3 in 26% of the cases. The tumour grading and primary extent of the endometrial carcinoma area are closely correlated. At a grading G1 90% of the cases were in stage I/II and only 10% in stage III/or IV. At a grading G3 23.8% of the cases were stage I/II and 76.2% of the cases stage III/IV. Based on the presented analysis it is recommended to supplement the conventional treatment at an invasion depth I 2/3 of I 3/3 with radiotherapy of the para-aortic lymph nodes since 27.3 to 50% of these cases show para-aortic metastases. In 17% of the endometrial carcinomas with an invasion depth I 3/3 exclusively para-aortic lymph node metastases were found which do not respond to conventional treatment.

Adult↗
PubMed1982

[Morphology and clinical aspects of malignant mixed müllerian tumors of the corpus uteri].

Mixed muellerian tumours of the uterus are more common today than uterine leiomyosarcomata. There is a world wide increase in the incidence in the last few years. In the past 15 years we observed 20 mixed muellerian tumours of the uterine body. The patients are usually 10 years older than women with endometrial carcinoma or leiomyosarcoma of the uterus. Morphologically homologous and heterologous tumours must be differentiated. Characteristic is the marked polypoid growth. There is a close correlation between tumour stage and microscopic tumour grading. Tumours with high malignancy are usually in stage I or II. The prognosis correlates well with the grade and stage of the tumour, therefore the elaboration of a prognostic index is necessary. The survival rates are low. Mixed muellerian tumours are not at all or very little influenced by radiotherapy. The single or combined chemotherapies in use o date have not shown satisfactory success. As complete as possible surgical removal is therefore important. It cannot as yet be predicted whether our present combined treatment in stage III and stage IV by operation and post-operative combined chemotherapy with CYVADIC is liable to increase the survival rates.

Aged↗
PubMed1982

[Morphology and clinic of ovarial teratomas (author's transl)].

This analysis covers 170 patients with teratomas from 1965-1978 in the Department of Obstetrics and Gynaecology of Heidelberg University. Malignant teratomas were found in two patients; in a special case, a "gliomatosis peritonei" was identified. The histological composition, the degree of maturity, grading and clinical staging were compared with regard to the prognosis and for obtaining an optimal therapeutic approach and procedure. Under the condition that an accurate and extensive histological diagnosis is obtained, "conservative surgery" seems to be the optimal therapy in fertile patients. In case of malignant teratoma, radical surgery followed by chemotherapy is imperative.

Adolescent↗
PubMed1981

[Preliminary results using the histocan needle biopsy for the microscopic evaluation of gynaecologic tumours (author's transl)].

In a preliminary study the new "Histocan"-needle was tested in respect of its diagnostic value in patients with palpatory findings suspicious for recurrent cancer in the pelvis and in patients with breast tumours. Initially there were some difficulties in handling the biopsy needle. Furthermore we saw some haematomas after breast biopsy, which could be avoided, however, by compression of the biopsy wound. From the morphological point of view the fine structures of tissue specimen were without the gross needle-conditioned artifacts and in some respect could be interpreted better than in Silverman-biopsies. Statistical data can only be given after finishing our cooperative studies.

Biopsy, Needle↗
PubMed1981

[Foundations for differential cytology of cervical changes. 1. Introduction and methods (author's transl)].

A brief historic account of the development of exfoliative cytology in the context of the uterine cervix is followed by discussion of the most important technical fundamentals for the preparation of cytological specimen smears. High-accuracy cytological diagnosis depends on careful preparation techniques, which is of particular importance when it comes to highly subtle differential cytology. The authors' own experience is likely to suggest that closest attention must be given to all empirical insights regarding collection of material, fixation, and staining, since this is the key for cytological specimens to provide from low technical and material input invaluable diagnostic information about most various lesions of the uterine cervix.

Cervix Uteri↗
PubMed1981

[Foundations for differential cytology of cervical changes. 2. Benign changes (author's transl)].

Causative relationships between various benign changes of the uterine cervix are discussed with reference to literature, and resulting cytomorphological substrates are presented in illustrations. Cytomorphological pictures obtained from good preparation practice often have been helpful in drawing proper conclusions as to causes of benign changes and in clarifying clinical patterns or portio changes which escaped macroscopic elucidation. Such changes may include inflammatory or degenerative lesions of differentiated aetiology, metaplastic processes in so-called transformation zones or at squamocolumnar junctions or abnormal cornification. As a rule, benign changes may be delimitated from atypical cell changes by the examiner who is aware of all direct and indirect cytological criteria.

Atrophy↗
PubMed1981

[Foundations for differential cytology of cervical changes. 3. Dysplasia and carcinoma in situ (author's transl)].

Reference is made in this paper to cytomorphological definitions as well as to epidemiological, aetiological, and pathogenetic aspects of cervical carcinomas and pertinent precancerous changes. Cytological criteria, including cytometric data of dysplastic changes, are compared to aspects of cervical carcinomas, and typical pictures are presented of various lesions. Measured cytological data proved to be suitable not only for objectivation of descriptive morphological findings, but they were found to be also useful aids for decision-making in differential cytology.--Diagnostic accuracy in the context of both dysplasias and cervical carcinomas can be in excess of 90 per cent, depending on good preparation practice and adequate diagnostic skill of the examiner.

Adenocarcinoma↗
PubMed1980

[Uterine sarcomas. Cytological diagnosis and differential diagnosis].

Cytomorphological findings in 8 cases of uterine sarcomas are being presented (2 endometrial stromal sarcomas, 2 so-called pleomorphic sarcomas, 3 leiomyosarcomas, 1 carcinosarcoma). The differential cytologic criteria are being discussed and demonstrated by microphotograms. By means of these cytologic findings in our opinion prospective cytologic diagnosis is possible also in these kinds of tumors. Final statistical conclusions in respect to cytologic criteria may only be drawn by greater numbers of cases, which can be reached only by cooperative studies on these relatively rare tumors.

Biopsy↗
PubMed1980

[Gliomatosis peritonei--a contribution to the biology of metastasising (author's transl)].

A rare case of "gliomatosis peritonei" is reported in a 16 year-old girl suffering from an adult ovarian teratoma with high-differentiated glia structures without malignancy. The histological grading of the primary tumor and its metastasis in the omentum majus seems to be contradictory to the ovarian-tumor-staging recommended by FIGO. The biological dignity of high-differentiated gliametastasis of an adult teratoma evidently allows a minimum of treatment because of good prognosis of this disease.

Adolescent↗
PubMed1979

[Vaginal metastases as the ist signs of primary occult hypernephroid kidney neoplasms].

Based on the literature and own observations it is pointed out that in cases of vaginal tumors as a rule a consequent search for tumors of the kidneys is necessary, because vaginal tumors may be metastases of primarily not identified hypernephroid carcinomas. The frequency of such metastases is reported to be about 2%. A search for kidney tumors is necessary, if histological findings of the vaginal tumor are clearly suspect for hypernephroid carcinoma, or if it cannot be clearly identified as a primary vaginal tumor or--as a metastasis--gives no certainty to be a metastasis of a primary tumor of other localization. Because of the relative statistical frequency of vaginal metastases from carcinomas of the kidneys a consiliary gynecological check up is necessary if the diagnosis of the tumor was primarily a urologic one to ensure that there are no vaginal metastases. Further diagnostic and therapeutic procedures are discussed.

Aged↗
PubMed1979

Sedimentation velocity separation: a preparation method for cervical samples.

A preparation procedure, aiming at monolayer deposition of cervical exfoliative material on glass slides for high resolution prescreening has been developed. The main features of this procedure are centrifugal deposition after suspension and sedimentation of samples over isopycnic medium of 1.026 density. Fractioning of the separation column after centrifugation at 50 X g yields two preparations with leukocytes, bacteria and cellular debris predominantly located on the first slide and epithelial cells on the second one. The degree of spatial cellular isolation as well as the amount of diagnostically relevant cells per slide seem to fit the requirements of automated high resolution analysis.

Cell Separation↗
PubMed1979

Cytomorphologic results of preparation experiments for monolayer deposition of cervical material.

For automated prescreening methods by high resolution analysis serving as a detecting method in gynecologic mass screening programs a new monolayer deposition method of cervical material has been used. This method will be outlines briefly and the mode of evaluation as well as current cytomorphological findings will be presented. With regard to measurability of the slides prepared according to the new method a number of cytologic criteria were thought to be of particular importance. These criteria are delineated and compiled in a table. A form in which these criteria were listed was filled in by cytopathologists for each slide evaluated. When performing isolation and centrifugation procedures several new morphologic questions arose to the cytopathologist which can only partly be answered by now. If taking into account all criteria of evaluation it may be followed from the present experiences that slides of cervical material are much more suited for automated prescreening methods by high resolution analysis if prepared after isolation and centrifugation in macromolecular liquids than are conventional Papanicolaou smears or slides from suspensions with isolated cells that were not subjected to centrifugation procedures.

Cell Separation↗