Biomedical subjects

H H Sandstead

Publications and source records attributed to H H Sandstead.

At least 145 records · Page 8Linked to original sources

PubMed1975

Some effects of prenatal zinc deficiency on behavior of the adult rat.

The effect of zinc deficiency during the latter third of gestation on avoidance conditioning of young adult male rats was compared with the effect of intrauterine starvation and normal pregnancy. Animals which had experienced zinc deficiency avoided shock less well than the offspring of pair-fed control dams. The offspring of pair-fed dams avoided shock less well than animals which were the product of normal pregnancy. Response latencies were inferior in the zinc-deficient group, whereas intertrial responses were less on both the previous zinc-deficient and intrauterine starved animals.

Animals↗

PubMed1975

Zinc deficiency and brain development in the rat.

Effects of prenatal and postnatal zinc deficiency on the composition of the brain and on subsequent adult behavior were studied. Deficiency throughout the latter third of pregnancy resulted in decreased body and brain size without affecting total brain DNA, RNA, or protein. Adult males that had been subjected to intrauterine zinc deficiency displayed impaired shock avoidance. Zinc deficiency from birth until 21 days of age resulted in impaired growth, decreased brain size, diminished brain DNA, RNA and protein. Cerebellar lipid concentration was also diminished. Such male animals displayed impaired maze acquisition as adults.

Animals↗

PubMed1975

The effects of a low level of dietary cadmium on blood pressure, '24Na, '42K, andwater retention in growing rats.

The effects of 5 pg Cd per millilter of drinking water on body weight gain, food intake, systolic blood pressure, '24Na, '42K; and water retention and freference for NaCl solution in male and female rats were studied. After 205 days, Cd had no significant effect on weight gain, food intake, water intake, or feed efficiency. The'24Na retention of the Cd-fed male and female rats was greater at 161 days than in the control animals and was significantly greater (P less than 0.05) in the Cd-treated females than in the control females at 294 days. In vivo retention of '42K was significantly greater in the Cd-treated males than in the control males at 189 days, butthe oppisite was true of the Cd-treated females in comparison with female control animals. There were no significant differences between treatments in '42K retention after 330 days. No significant differences were found between treatments in systolic blood pressure. Water retention was significantly greater in the Cd-treated males and females than in the control animals after 320 days. Preference for 0.20 M NaCl was significantly greater in the Cd-fed males than in the control males at 277 days. Possible mechanisms which might explain the sodium retention in thhe Cd-fed rat are discussed.

Animals↗

PubMed1975