[Pathological changes in the human body in acute and chronic cadmium poisoning].
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Biomedical subjects
Publications and source records attributed to H Grzybek.
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In the group of rabbits chronically intoxicated with petrol vapour slight changes in the dust cells of lungs in the form of cytoplasmic vacuolisation and accumulation of collagen almost completely disappeared 3 months after intoxication. Changes in animals intoxicated with ethyline were much more severe. Besides the accumulation of collagen, appearance of elastin areas, cytolysosomes, changes in the nucleus, widening of ergastoplasm, swelling and cristolysis of mitochondria were observed. Three months after intoxication the decrease of previously observed changes was noted.
Structural changes in brain mitochondria of mice subjected to hyperthermia have been examined under the electron microscope. In electronmicrographs of mice heated up to 41 degrees C the mitochondria were slightly damaged and those heated up to 42 degrees C showed marked destruction.
Skin specimens were taken without any anaesthesia from four volunteers before and after a 1 hour's exposure to heat. No glycocalyx could be demonstrated in the resting gland, but it usually appeared, however, after one hour of thermal sweating--although not in all the sections. The possible implication of this phenomenon is briefly discussed and new problems outlined.
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The experiments were carried out on male Wistar-Rats. They were divided into 2 groups. The rats of the control groups were treated to Phenobarbital intraperitoneally for 3 consecutive days. The animals of the experimental group were additionaly injected with Benzen intraperitoneally on the 4th day of experiment. It has been found that Phenobarbital brought about the formation of 2 types of bright and dark cells in the liver. The action of Phenobarbital is carried on by Benzene. The authors discuss morphological and functional evaluation of bright and dark cells from the point of view of stimulating action of Phenobarbital as well as the course of Benzene biotransformation in liver cells.
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