Search PubMed⌕ Search

Biomedical subjects

H Grimm

Publications and source records attributed to H Grimm.

At least 109 records · Page 6Linked to original sources
PubMed1988

[Colorectal carcinoma--endoscopic diagnosis and therapy].

Endoscopic diagnosis and therapy of colorectal carcinomas comprise their early and late forms. In adenomas with invasive carcinoma, polypectomy is at the same time a complete therapy if the site of removal is histologically free from any tumour. In case of established invasion of the submucous lymphatic vessels and a low degree of differentiation subsequent segmental resection is generally recommended. Advanced carcinomas do not present any special problem in respect of identification by endoscopy. Biopsy can also be performed at the same time. In case of inoperable tumours, endoscopy offers by means of the YAG laser an additional palliative treatment method for extending the lumen or haemostasis.

Colonic Neoplasms↗
PubMed1987

In vitro study with ciprofloxacin: interpretive criteria of agar diffusion test according to standards of the NCCLS and DIN.

Regression analyses to determine the correlation between minimal inhibitory concentrations (MICs) and inhibition zones produced by ciprofloxacin disks were carried out using 400 freshly isolated cultures of infective organisms (approximately 20 strains from each of 22 species). It was found in pilot studies that the correlation becomes weaker with increasing disk loads (1, 5, 10, and 30 micrograms). Disks containing 5 micrograms of ciprofloxacin were chosen for comparative studies using Mueller-Hinton agar and methods of the National Committee for Clinical and Laboratory Standards (NCCLS) as well as of the Deutsches Institut für Normung (DIN 58940). Based on preliminary MIC breakpoints (susceptible, 1 microgram/ml or less; intermediate, 2 micrograms/ml; and resistant, 4 micrograms/ml or more) and calculations from regression equations (limited to the MIC range of 0.25 to 32 micrograms/ml), the following zone interpretations using the NCCLS method are recommended: resistant, 15 mm or less; intermediate, 16 to 20 mm; and susceptible, 21 mm or more. The respective values with the DIN method are resistant, 18 mm or less; intermediate, 19 to 22 mm; and susceptible, 23 mm or more.

Bacteria↗
PubMed1987

N-butyl-2-cyanoacrylate: a supplement to endoscopic sclerotherapy.

We report on our two years' experience with the tissue adhesive n-butyl-2-cyanoacrylate. During this period 202 patients suffering from esophagogastric varices were treated endoscopically. With the aid of the tissue adhesive the conventional sclerotherapy with Polidocanol 1% has been clearly improved. Problems concerning early recurrent bleeding and fundic varices are satisfactorily solved. The endoscopic hemostasis of severe variceal bleedings has become safer and surer. The overall hospital mortality of these patients has sunk from 31.5 to 17.5%. Cyanoacrylate is a very useful substance for obliterating large esophagogastric varices. However, the complete elimination of esophageal varices, which is the guarantee for a long-term freedom from recurrent bleeding, can only be achieved by using a genuine sclerosing agent.

Enbucrilate↗
PubMed1987

Interpretive criteria for the agar diffusion susceptibility test with ofloxacin.

Regression analyses to determine the correlation of minimal inhibitory concentrations (MICs) and inhibition zones produced by ofloxacin discs were carried out with 300 freshly isolated cultures of infective organisms (20 strains from each of 15 species). After pilot studies, 5 micrograms loaded discs were chosen. Studies were performed simultaneously by using ICS/DIN and Kirby-Bauer/NCCLS methods on Mueller-Hinton agar. It was found that the correlation becomes poorer with increasing disc loads and when the Kirby-Bauer method is used. Based on preliminary MIC breakpoints of greater than or equal to 2 mg/L and greater than or equal to 8 mg/L and by calculations from regression equations, the following zone interpretations using the NCCLS method are recommended: resistant up to 12mm, intermediate 13 to 15mm, susceptible 16mm or more. The values for the DIN method are: resistant up to 13mm, intermediate 14 to 17mm, susceptible 18mm or more. No major errors were found in zone interpretations. Minor errors were observed in 0.7% when the NCCLS method was used, and in 1.3% with the DIN method.

Agar↗
PubMed1987

[In vitro comparison of the beta lactamase-inhibitory action of clavulanic acid and sulbactam in ampicillin-resistant enterobacteria].

Comparative in vitro Studies of the beta-Lactamase Inhibitory Effects of Clavulanic Acid and Sulbactam on Ampicillin-resistant Enterobacteria. Clavulanic acid and sulbactam alone are infective against Pseudomonas and enterococci. Staphylococci and enterobacteriaceae are inhibited by high concentrations not attainable under clinical conditions. Strains of Acinetobacter, especially A. lwoffii are susceptible to clavulanic acid and highly susceptible to sulbactam. The sulbactam-ampicillin combination is superior to clavulanic acid-ampicillin against C. freundii, Enterobacter spp. and M. morganii. The latter combination is superior against Klebsiella spp. and E. coli. Antagonistic effects are more frequent with the clavulanic acid combination (Enterobacter spp. and C. freundii) but are rarely observed with the sulbactam combination (Providencia spp. and P. rettgeri).

Ampicillin↗
PubMed1986

[Endoscopic transpapillary drainage of Wirsung's duct in chronic pancreatitis].

Endoscopic transpapillary drainage of the main pancreatic duct is a novel, non-surgical method for the treatment of chronic pancreatitis. It seems to be particularly suited for the obstructive form characterized by dilatation of the duct system due to stenoses. Up to now drainages could be successfully performed in five out of six patients. In three cases a divided pancreas was present. The preliminary results are favourable: pain was almost completely eliminated and the patients gained weight. Complications due to the intervention have not been registered as yet. There was no obstruction or dislocation of catheters over an observation period of up to 18 weeks.

Adult↗
PubMed1986

[Criteria for the interpretation of sensitivity testing of ofloxacin with the agar diffusion test].

Regression analyses to determine the correlation of MIC and inhibition zone produced by ofloxacin disks were carried out using 300 freshly isolated cultures of infective organisms (20 strains each from 15 species). It was found in pilot studies that the correlation becomes poorer with increasing disk loads. Disks containing 5 micrograms of ofloxacin were chosen for comparative studies using Mueller-Hinton agar and Kirby-Bauer, as well as DIN-58940 methods. Based on preliminary MIC breakpoints of 1 and 4 mg/l and on calculations from regression equations, the following zone interpretations using the Kirby-Bauer method are recommended: resistant = up to 12 mm, intermediate = 13 to 19 mm, susceptible = 20 mm or more. The respective values for the DIN method are: resistant = up to 14 mm, intermediate = 15 to 21 mm, susceptible = 22 mm or more. The results are similar to those obtained by us in previous studies with norfloxacin, enoxacin and ciprofloxacin.

Anti-Bacterial Agents↗