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Biomedical subjects

H Graham

Publications and source records attributed to H Graham.

At least 55 records · Page 3Linked to original sources
PubMed1981

Prediction of the severity of ABO haemolytic disease of the newborn by cord blood tests.

Seventy-one ABO incompatible (heterospecific) infants and 71 controls, who were free from other potential causes of jaundice, were studied to ascertain which cord blood tests reliably predict the severity of ABO haemolytic disease of the newborn (ABO HDN). The modified Direct Antiglobulin Test (spin DAGT) was positive in all infants who required treatment for haemolytic jaundice and only DAGT positive children showed evidence of impending haemolytic anaemia or compensated haemolysis in cord or capillary blood. Cord serum bilirubin concentration had some predictive value, particularly when the level exceeded 85 mumol/l, but it was a less reliable indicator and had greater value if used in association with the DAGT. The elution test, which is frequently used as a diagnostic tool in ABO HDN, had no predictive value and we felt that its putative value is due to overdiagnosis of ABO HDN in jaundiced heterospecific infants. We conclude that the spin DAGT, despite the weakness of the reaction, reliably identifies infants at risk from severe ABO HDN and is sufficiently sensitive to be used as a single screening test for the early detection of the disorder.

ABO Blood-Group System↗
PubMed1981

Fine-structure studies of experimental skeletal muscle trauma.

A study was made of damage to skeletal muscle caused by a high-velocity rifle bullet. Such damage extends peripherally from the permanent wound cavity and is focal in nature. A fine-structure investigation of this region suggests that some components of the muscle are more susceptible to the wounding process than others. The sarcoplasmic reticulum appeared most sensitive and areas as far as 3 cm from the wound cavity frequently showed gross vacuolization. Mitochrondrial damage was seen, but only in areas where there was also damage to myofibrils and the microvasculature. Focal capillary leakage up to 3 cm from the wound cavity was demonstrated in an earlier study by the use of a fluorescein-labelled dextran (Paddle and Freeman, 1979). This finding was confirmed. A possible correlate at the fine structural level was swelling of te capillary endothelial cells, which occurred in the absence of other signs of microvascular damage. Damage to the endothelial junctions was not observed, even in severely damaged tissue. Intravascular colloidal carbon escaped into the extravascular space only when the microvasculature was fractured. The relationship of these findings to macroscopic damage is discussed.

Animals↗
PubMed1979

Breast or bottle.

Explore the source record for details and available documents.

Attitude of Health Personnel↗
PubMed1978

Advisory arbitration: the experience in Illinois.

The authors reviewed 266 cases of advisory arbitration in Illinois between 1972 and 1975 to determine the issues arbitrated, representations, winners and losers, and whether awards were rejected at the state level. The views of the employee groups using the procedure are also discussed. The authors conclude that the Illinois procedure produces results similar to binding arbitration.

Employee Grievances↗
PubMed1976

Social work and general practice. A report of a three-year attachment.

Much has been written about social worker/general-practitioner collaboration, particularly about conflict of roles, differing functions, avenues of accountability, and problems of distributing scarce resources.We suggest that if the two professions are to work more comfortably together, then it is imperative that both also share the despair, hopelessness, anxiety, and anger that are the occupational hazards of each. We suggest ways in which doctors and social workers can look at the pain their patients are suffering to the benefit of the patient and their own working relationship.

Family Practice↗
PubMed1975

A simple method for the prediction of ABO incompatibility using Sephadex A-50. Prediction of ABO incompatibility.

A rapid and simple method of demonstrating the presence of high titre IgG anti-A or anti-B (anti A/B) is described. The method requires the separation of IgG anti-A/B from IgM anti-A/B using DEAE Sephadex A-50 by a simple spin technique, and the subsequent titration of the IgG fraction to detect the presence of high titre IgG anti-A/B. Since high titre IgG anti-A/B is usually associated with ABO incompatibility the test is a useful guide to the prediction of ABO incompatibility in routine antenatal samples.

ABO Blood-Group System↗