Biomedical subjects
H Goldschmidt
Publications and source records attributed to H Goldschmidt.
Teleroentgen therapy for mycosis fungoides.
Different techniques of teleroentgen therapy with soft X rays for total body treatment of cutaneous lymphomas are described. Therapeutic results in 26 patients with mycosis fungoides are reported.
Radiotherapy of benign dermatoses: indications, practice, and results.
Limited indications for radiation treatment of benign dermatoses are presented in order to emphasize modern restrictions and techniques in the use of dermatologic radiation therapy and to promote measures of protection against stray radiation. The use of softer, less penetrating X rays, least effective doses and meticulous shielding are recommended. So done, radiation therapy offers an effective therapeutic alternative for conditions that do not respond to other forms of treatment.
[Roentgen therapy of dermatoses: indications and hazards].
Indications for radiotherapy of benign dermatoses have decreased markedly during the past decades. The remaining indications are reviewed. Side effects of ionizing radiation therapy are discussed in detail, with special emphasis on radiodermatitis and radiation cancer of the skin, mutagenic and genetic effects of x rays, and induction of carcinogenesis of interanl organs. Thyroid cancer is used as an example to discuss modern theories of radiocarcinogenesis and risk coefficients of various organ systems. Guide lines for radiotherapy of benign dermatoses are proposed.
Food and Drug Administration recommendations on radiation of benign diseases.
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Acne fulminans: investigation of acute febrile ulcerative acne.
Eight cases of acne fulminans (acute febrile ulcerative acne) are compared with 13 previously reported cases. This rare disorder of male teenage patients is characterized by the sudden appearance of highly inflammatory, tender, ulcerative and crusted lesions on the back, chest, and face: it is one of the most scarring acute dermatologic disorders of young patients. At the onset of the disease, all patients showed febrile temperatures and marked leukocytosis; other systemic symptoms occurred with varying frequency. Polyarthralgia was noted in half of our series. Investigations of potential trigger mechanisms (eg, septisemia due to Corynebacterium acnes, immunologic defects, altered polymorphonuclear leukocyte function, Shwartzman phenomenon) did not yield any clues regarding the pathogenesis of this disease. Clinical and laboratory findings suggest that acne fulminans is not directly related to acne conglobata.
Dermatologic radiotherapy and thyroid cancer.
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[Hemihypertrophy, nevus sebaceous, multiple bone cysts and cerebroretinal angiomatosis: a complex phakomatosis].
Report on a girl, who died at the age of 6 1/2 years having exhibited different dysplasias which are characteristic features of several phakomatoses: congenital cutaneous pigmentations, fibrolipoma of the scalp, hypertrophy of the right leg, multiple cysts of the long bones (fibrous dysplasia), and an aneurysma racemosum of the retina and mid-brain (syndrome of Bonnet-Blanc-Dechaume).
[Different ventilation of lungs - an indication for angiography of pulmonal-artery? (author's transl)].
The radiological symptom of different ventilation of each lung has various causes. There are birth defects and diseases. Different, invasive and non-invasive methods are necessary for diagnosis. The way of diagnosis is shown by an 11-year old girl with absence of the left pulmonal-artery. The different methods are discussed and various own cases of agenesie of the pulmonar-artery in combination with others dysplasias are added.
Dermatologic radiotheraphy: selection of radiation qualities and treatment techniques.
The penetration of x-rays should be correlated the depth of the pathological process. The introduction of the "half-value depth" (D1/2) as a guidline in the selection of radiation qualities has greatly simplified cutaneous radiotherapy. Modern dermatologic x-ray units with beryllium windows operated between 10 and 50 (or 100 kV, offer the widest spectrum of radiation qualities suitable for dermatologic therapy, although older types of radiation equipment are still useful for most dermatology indications. Previous risks in dermatologic radiation therapy have been reduced to a large degree by the introduction of new sophisticated safety devices and by a deliberate reduction of unnecessary variations in the selection of physical factors. Beryllium window machine can be operated without changing milliamperage, target-skin distance or dose rate for different indications. The recommended standardization of physical factors offers a safer and easier alternative to previous techniques.
Radiotherapy of skin cancer: modern indications and techniques.
Skin cancer is the most frequent indication for radiation therapy in dermatology. X-ray treatments are particularly valuable in cutaneous neoplasms in special anatomical locations. Advantages and disadvantages of dermatologic radiation therapy are outlined, and modern indications, radiation methods and the selection of physical radiation factors are discussed.
Task force reports: dermatologic radiotherapy and thyroid cancer.
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Contact radiotherapy of cutaneous hemangiomas: therapeutic effects and radiation sequelae in 818 patients.
The paper presents statistical data on the therapeutic effects and radiation sequelae following Chaoul contact therapy of 818 cutaneous hemangiomas treated between 1938 and 1952. 73.3% of all irradiated hemangiomas showed initial improvement but complete involution with an excellent cosmetic result was observed in only 50% of lesions 5 years after treatment. During the same period of time, more than one-third of all patients developed mild to moderate cutaneous radiation sequelae (hyper- or hypopigmentation and telangiectases, rarely atrophy). The high incidence of late radiation effects is probably relation to the high total doses administered in this series of patients, the very short intervals between treatments and the age of the patients. Other radiation radiation hazards are also discussed. Since large studies have proven conclusively that spontaneous involution occurs in 95% of hemangiomas after several years, indications for radiotherapy of hemangiomas are extremely limited.
[Trichostasis spinulosa. A frequent follicular age-dependent change of the facial skin].
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Ionizing radiation therapy in dermatology. Current use in the United States and Canada.
A comprehensive survey of the Task Force on Ionizing Radiation of the National Program for Dermatology was answered by 2,444 dermatologists in the United States and Canada (53.6% of 4,560 questionnaires). Computer analysis of the data showed that 55.5% of dermatologic offices are equipped with superficial x-ray machines and/or grenz ray units and that 44.3% of dermatologists use superficial x-ray or grenz rays regularly. Most respondents (65.8%) favor increased practical instruction in radiotherapy in training programs. A majority (63.4%) want examinations in radiation therapy by the American Board of Dermatology continued or increased. Data dealing with training in radiation therapy, reasons for non-utilization, alternate care, radiation safety, and economic considerations are presented in detail. Common indications for superficial x-ray therapy and grenz ray therapy are listed in order of frequency and percentage of use.
[Atypical and complex phakomatoses in a 6-year-old girl].
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[Wilms' tumor in the newborn infant. Statistics and results of follow-up studies].
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Bladder necrosis caused by use of THAM in a newborn infant.
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