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Biomedical subjects

H Goldschmidt

Publications and source records attributed to H Goldschmidt.

At least 145 records · Page 8Linked to original sources
PubMed1987

Idiopathic hemochromatosis presenting as amenorrhea and arthritis.

Idiopathic hemochromatosis in young adults has been increasingly recognized over the last three decades. Younger patients with hemochromatosis frequently have presenting problems other than diabetes, cirrhosis, and hyperpigmentation. A young woman with idiopathic hemochromatosis is described. Arthritis and secondary amenorrhea developed at age 20, and liver biopsy showed hemochromatosis at age 29. Further work-up revealed that the amenorrhea was due to underproduction of pituitary gonadotropins. The patient was treated with phlebotomy. Estrogen and progesterone replacement was begun because of severe osteoporosis. Serum iron studies may be useful in young patients with unexplained amenorrhea and/or arthropathy.

Adult↗
PubMed1987

[Determination of the S-phase fraction of myeloid-determined stem cells (CFU-GM) using the cytosine arabinoside suicide technic in patients with acute myeloid leukemia in complete remission following polychemotherapy].

S-phase fraction of granulocyte-macrophage colony forming cells (CFU-GM) was assessed by cytosine arabinoside suicide technique in five normal volunteers and eight patients with acute myeloblastic leukaemia in complete remission after the cessation of polychemotherapy. An increased proliferation of CFU-GM (S-phase-fraction: 55-80%) was found in bone marrow of patient in complete remission up to the 27th day after polychemotherapy. Reduction of this increased proliferation was seen at day 30 after the cessation of polychemotherapy (S-phase fraction: 22 and 33%). Because of increased proliferation of CFU-GM in the early phase after polychemotherapy cytostatic drugs of the antimetabolite-type seem to be unsuitable for purging bone marrow in remission.

Adolescent↗
PubMed1986

[Clinical aspects of autoimmune hemolytic anemias].

In a retrospective examination are evaluated the clinical, haematologic and immunohematologic findings as well as the courses of the disease of 119 patients with autoimmunohemolytic anaemia (AIHA), i.e. 113 AIHA by thermic autoantibodies (-wa) and 6 AIHA (-co), consequently, AIHA-wa were observed 19 times more frequently than AIHA-co. Symptomatic AIHA-wa appear somewhat more frequently than idiopathic forms (60:53). The serum iron values are in most cases within or near the normal region in idiopathic as well as in symptomatic AIHA-wa. In 75% of the patients with idiopathic AIHA-wa a remission of the haemolysis could be achieved by a glucocorticoid treatment. A primary immunosuppressive combination therapy (glucocorticoids + azathioprine) was successful in all 8 patients. In one third of the patients the AIHA-wa could be cured, on the one hand, after one year the lethality was 33% (Dacie 1963 still 46%). The indication for splenectomy is discussed, since by means of this third therapy possibility a favourable influence of the course could be achieved in half of the 22 patients with symptomatic and idiopathic AIHA-wa. The importance of the thromboembolic complications is to be confirmed. So pulmonary embolisms are the most frequent cause of death in the 53 patients with idiopathic AIHA-wa. The concentration of the patients with AIHA in haematologic centres proved to be advantageous for these patients.

Adult↗
PubMed1983

Dermatologic radiotherapy and thyroid cancer. Dose measurements and risk quantification.

Thyroid doses for various dermatologic radiation techniques were measured with thermoluminescent dosimeters and ionization rate meters in an Alderson-Rando anthropomorphic phantom. The effects of changes in radiation quality and of the use or nonuse of treatment cones and thyroid shields were evaluated in detail. The results indicate that the potential risk of radiogenic thyroid cancer is very small when proper radiation protection measures are used. The probability of radiogenic thyroid cancer developing and the potential mortality risk were assessed quantitatively for each measurement. The quantification of radiation risks allows comparisons with risks of other therapeutic modalities and the common hazards of daily life.

Acne Vulgaris↗
PubMed1982

Dermatologic radiotherapy and breast cancer. Dose measurements and risk quantification.

This study was set up to provide quantitative data to evaluate unsubstantiated claims that improper dermatologic radiation techniques may cause breast cancer. A thin mylar window ionization rate meter placed at the location of the right breast of an Alderson-RANDO anthropomorphic phantom was used to measure direct and scatter radiation reaching the female breast during radiotherapy of the facial region (as given for acne). The results indicate that scatter doses are very small; they are influenced by radiation quality and the use or nonuse of a treatment cone. Quantitative risk estimates show that the very small risk of breast cancer induction can be reduced even further by the use of proper radiation protection measures.

Acne Vulgaris↗
PubMed1982

[Dermatologic roentgen therapy and radiocarcinogenesis].

Late somatic effects of ionizing radiation can be divided into non-stochastic effects with relatively high threshold doses (cataract, fertility problems, chronic radiodermatitis, and radiogenic skin cancer) and non-threshold stochastic effects. Theoretical and epidemiologic aspects of radiocarcinogenesis and various clinical types of radiation-induced neoplasms (leukemia, thyroid cancer, breast cancer) and genetic effects are discussed with special reference to radiation protection measures.

Breast Neoplasms↗
PubMed1980

Reactions to ionizing radiation.

This review deals with essential physical and biologic aspects of ionizing radiation as related to dermatology. The discussion of major physical factors and basic biophysics includes the production of x rays, dose definitions and recent changes in terminology, various factors affecting dose and tissue damage and current radiotherapy methods. The biologic effects and potential risks of ionizing radiation are reviewed in detail, particularly the major nonstochastic and stochastic somatic effects, such as radiation-induced skin cancer, thyroid carcinoma, breast cancer, and other radiogenic neoplasms. Current methods of risk assessment, radiation carcinogenesis, the efficacy of radiation protection technics, and potential genetic effects are critically evaluated.

Breast Neoplasms↗
PubMed1979

Surface area measurements of psoriatic corneocytes: effects of intralesional steriod therapy.

Quantitative measurements of surface areas of corneocytes from the desquamating portion of psoriatic lesions in 11 patients showed that psoriatic corneocytes were much smaller (27%) than corneocytes from noninvolved normal skin in the same patients. Corneocyte surface areas gradually increased in size following one intralesional injection of triamcinolone acetonide suspension and were almost normal approximately 6 weeks after treatment. These findings support other observations suggesting that rapidly proliferating epidermal cells have smaller surface areas than normal cells.

Adult↗