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Biomedical subjects

H Gin

Publications and source records attributed to H Gin.

148 records · Page 9Linked to original sources
PubMedDate not supplied

[Does glycemic level influence the pharmacokinetics of an antibiotic (cefoperazone)?].

Hyperglycemia may modify pharmacokinetics of some antibiotics as shown in the literature. We studied the influence of glycaemic levels on pharmacokinetics properties of cefoperazone in 12 type 1 insulin dependent diabetic patients. Hyperglycaemia was obtained by a reduction of one quarter of their usual insulin dosage and normoglycaemia by an artificial pancreas (Biostator GCIIS). Cefoperazone had a high protein affinity and a high biliary elimination. Pharmacokinetic study was performed during a 8 hour period following one gram intravenous bolus. We did not found any influence of glycaemic level (normoglycaemia or hyperglycaemia) on the pharmacokinetic parameters of cefoperazone.

Blood Glucose↗
PubMedDate not supplied

Action of a semi-synthetic human insulin preparation (30/70 NPH insulin Organon): comparison with another 30/70 NPH (Actraphane Novo).

The action of a new semi-synthetic insulin preparation (30% soluble, 70% NPH insulin from Organon Laboratories Eragny sur Epte France) was studied in 6 healthy male volunteers using the euglycemic clamp technique (Biostator GCIIS) and compared with another 30/70 NPH (Actraphane Novo). Insulin levels, inhibition of C peptide secretion and glucose consumption were determined. There was a time lag between the maximum glucose need (167 +/- 18 mg/Kg/15 min at the 195th minute after the injection) and the peak plasma insulin level (98.3 +/- 8.5 uu/ml at the 105th minute following the injection). The maximum glucose need was followed by a slow fall in insulin levels with a duration of action of 17 hours. The total glucose need was the same as for Actraphane, although Actraphane had a slower action with a lower peak glucose need (144 +/- 18 mg/Kg/15 min at the 280th minute after injection). The two preparations had the same duration of action.

Blood Glucose↗
PubMedDate not supplied

[Surgery of insulinomas using an artificial pancreas].

The risks of failure of conventional treatment of insulinomas should be reduced, it seems, when the surgical operation is carried out using an artificial pancreas. The Biostator, used with feed back controlled glucose infusion in 32 cases of which two personal effectively allows one firstly to operate in complete security since it is programmed to maintain a pre-determined glycaemia during the various stages of the operation; it also allows one to put into evidence an occult tumour in a segment rendered suspect due to the sudden hypoglycaemia observed during its mobilisation; it finally allows one by the appearance of a post-excision hyperglycaemia peak to find out whether the procedure has been complete.

Adenoma, Islet Cell↗