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Biomedical subjects

H Gerlach

Publications and source records attributed to H Gerlach.

At least 127 records · Page 7Linked to original sources
PubMed1982

[Is the "second look" justified after cholesteatoma surgery according to the closed technique? (Our concept of "indicator-pearl")].

Among 1218 tympanoplastic operations of the last three years we found 507 cholesteatomas. In primary operations we chose the closed technique for 287 and the open technique for 77. In 143 cholesteatoma post operations 60 remained closed but 83 were already been modified in favour of the open technique. In 123 "Second look" operations we found 25 recurrences, i.e. 20%. This results in the following aspects: 1. In spite of strictest indications for the closed technique we found recurrences in 20% of the necessary "Second look" operations. In all cases we could maintain the closed technique. This alone justifies the "Second look". 2. No ideal time for the performing the "Second look" to exclude a further recurrence can be named. We believe according to our experience that the most favourable time to operate is after one year. After such a period a recurrence shows itself consequently in a "stadium nascendi" in form of a small pearl, being a carrier of an epithelial rest, which can be easily removed. We call this finding "Indicator-Pearl".

Cholesteatoma↗
PubMed1981

[Open or/and closed operation technic in case of cholesteatoma (author's transl)].

The different, but partly very high percentage of recurrence cholesteatoma and the by that necessary re-operations could lead to the conclusion to turn away from the closed operation technic. We have tried by means of 654 re-operations to find out the reasons for failures made by us and others. From this result conclusions were drawn in regard of improving diagnosis, indication and therapy. - Both operation technics shall for the future keep their right to exist, but with a different indication basis. We give the open technic - because for the advantage of its radicality against the cholesteatoma - again more change, keep in mind to use in addition the Mastoid Obliteration Method. The "second look" in case of the closed technic should be indicated exceptionally.

Cholesteatoma↗
PubMed1980

[Involvement of the central nervous system in generalized non-Hodgkin's lymphomas (author's transl)].

The value of the Kiel classification of non-Hodgkin's lymphomas (NHL) in neuro-oncology is supported by a systematic prospective study of the CNS in 131 autopsies with NHL. In 31 (23.7%) cases the CNS was involved, mainly in lymphoblastomas (11) and immunocytomas (10). Tumour manifestations of the CNS were found in 17 (20%) out of 84 low grade and 13 (34%) high grade malignant NHL. In plasmocytomas of the bone marrow the CNS was rarely affected. As only one fourth of the CNS infiltrations in lymphomas showed naked-eye appearances, a careful histologic examination of the brain, spinal cord, nerve roots and spinal ganglia, respectively, is necessary for evaluation of the CNS involvement in NHL. The cause of the different incidence of CNS manifestation in various types of NHL is obscure. Further investigations including immunologic, clinical and therapeutic studies have to be carried out for solving this problem.

Adolescent↗
PubMed1979

[The application of cortical bone avoiding retraction pockets in case of cholesteatoma operations (author's transl)].

All those different operation methods thought for the preservation and reconstruction of the posterior canal wall in the last decennium show us in a high degree the extension of the problems. We ourselves have--after first enthusiasm for the "temporary meatotomy"--later preferred the "combined-approach-technic". Hereby the care to avoid retraction pockets in the lateral attic wall stood ahead. After the first use of muscle, connective tissue and fascia, later on the lyophilised dura and the cartilage, we today prefer cortical bone of the planum mastoideum. This is thought to be the original material for this purpose not having been in touch with the cholesteatoma or the matrix and guarantees by the accompanied periosterm a seamless pass over to the remaining canal wall. Also an additional usage of lyophilised dura--situated bricklike along the separating line--avoids a new retraction. In case of the slightest suspection for the possibility of a residual cholesteatoma a "Second look" operation should be carried out one year after the first operation. A further control should follow after 5 years.

Cholesteatoma↗
PubMed1979

[Primary malignant lymphomas of the central nervous system (author's transl)].

9 primary malignant lymphomas of the CNS were found at autopsies. The youngest patient was 4 months and the oldest 69 years of age. The lymphomas were classified in accordance with the Kiel classification. Most of them were immunoblastomas and immunocytomas. The neoplastic transformation seems to start in the adventitia of the blood vessels. From there the tumour cells invade the brain tissue and the meninges. A multifocal origin of primary lymphomas of the CNS has been seen in some cases. An isolated development of primary lymphomas of the spinal cord is not present in our material. The pathogenesis of the primary malignant lymphomas of the CNS is discussed.

Adult↗
PubMed1978

[Isolated neoplastic foci in the central nervous system in generalized non-Hodgkin-lymphomas. A prospective pathomorphological study (author's transl)].

A comprehensive post-mortem investigation of the central nervous system (CNS) in 103 patients with malignant non-Hodgkin-lymphomas was performed. Neoplastic foci were revealed in the CNS in 21 cases. Five of them were visible at gross examination. Strong evidence exists that the incidence of the CNS-involvement is correlated with the lymphoma-type. Our cases were classified according to the Kiel-classification (Lennert 1975). The findings suggest that CNS-infiltrations are rather common in lymphoblastomas and immunocytomas whereas they seldom occur in plasmocytomas.

Adolescent↗
PubMed1978

[Morphology of heart tumors in rats induced by methyl- and ethylnitrosourea].

The results of morphological examinations of 78 heart tumors in BD IX rats induced by methyl- and ethylnitrosourea (MNU, ENU) administered by various routes are described. After repeated intravenous or intraperitoneal injections of MNU heart tumors developed in 39--46% of the treated animals. The following localizations were found: left ventricle--55, right ventricle--7, both ventricles--12, other sites--4. In 51 (65.4%) of 78 cases there were early stages of tumor with a ribbon-like lining of the affected ventricle wall. They consisted of elongated stream-like-arranged tumor cells. Large tumor nodules protruding into the ventricular lumen usually showed considerable features of cellular and nuclear polymorphism. The heart tumors were classified as fibromas or neurinoma-like tumors, fibrosarcomas, and polymorphous sarcomas. Histogenetically, the neoplastic cells are probably derived from fibroblasts and Schwann cells.

Animals↗
PubMed1978

[Early stages of experimental brain tumours in rats. Investigation of serial sections (author's transl)].

The results of transplacental induction of brain tumours by a single intravenous injection of ethylnitrosourea in a dosage of 20 or 30 mg/kg body weight to pregnant BD IX and Albino rats on the 17th day of gestation are presented. From 46 animals of the offspring 43 rats developed 185 intracranial neoplams. 157 of them were early stages. Most of the animals had multiple tumours. One rat showed 13 separate tumour nodules. The average number of brain tumours was 4.3 per rat. 101 tumours had a diameter of less than 1 mm. The neoplasms were classified as 179 glial tumours (mainly polymorphous gliomas, oligodendroastrocytomas and oligodendrogliomas), 4 sarcomas and 2 gliosarcomas. All the oligodendrogliomas and about two thirds of the polymorphous gliomas were early stages. The following preferential localizations in the rat brain were established: White matter of cerebrum, hippocampus, basal ganglia, cortex of cerebrum and brain stem. 25.4% of the tumours were localized in the subependymal area. Bulbus and tractus olfactorius, leptomeninx, and cerebellum were very rare sites of tumour growth.

Animals↗