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Biomedical subjects

H Gao

Publications and source records attributed to H Gao.

At least 253 records · Page 14Linked to original sources
PubMed1992

[Analysis of the linear migration of the radionuclide along meridians in perfused extremities of monkey].

On the basis of researches in human body, further experiment in monkeys was conducted and the result has demonstrated that: 1. There was a close and complicated relation between the migration of 99mTc injected into acupoints and the blood circulation. 2. The location of the migration was mainly in the subcutaneous lay. 3. There were no direct relationship between the migration and periphery nerve system.

Animals↗
PubMed1992

[Preliminary observation of imaging of facial temperature along meridians].

Visualization of meridians has been carried out by means of infrared thermography and radionuclide scintigraphy, but real success was hardly achieved on some special regions including facial channels. In this paper, we would represent some imagings of thermal line along channels by means of infrared thermography. Distribution of the facial temperature in 139 cases of healthy volunteers and 305 cases of patients with facial paralysis was observed with model AGA-782 infrared thermovision and TC-800 computer. In all cases of patients and 15 cases of healthy persons, acupuncture test was conducted. Special program, DISCO3.1 was used to process the thermographic data and the results were as follows: 1. Facial thermal line along channel was presented in 95 out of 444 cases. High temperature line along bladder channel appeared in 34 cases of them; 2. In 26 out of 95 cases, the thermal line appeared after acupuncture, which could improve the imaging of the line; 3. The range of the temperature was within 1.3 degrees C, in some cases only 0.2-0.3 degrees C, with +/- 0.5-1.0 degrees C difference to surrounding temperature; the width of the line was 1-1.5 cm in most cases; 4. The line could appear stably, in some cases, last for several days, weeks or months; 5. Certain relationship between the appearing of the line and facial paralysis was found. As mentioned above, the thermal characteristics of meridians in face could be visualized by means of infrared thermography, the special imaging of facial temperature along bladder meridian was easily found, related to facial troubles and promoted by acupuncture.

Acupuncture Therapy↗
PubMed1992

Determination of arctiin and arctigenin in Fructus Arctii by reverse-phase HPLC.

The fruits of Arctium lappa L. is an often-used herbal drug in traditional Chinese medicine for the treatment of common cold caused by wind and heat. This drug contained many constituents, principally arctiin, with arctigenin in smaller amount. In this work, arctiin has been isolated from the fruits of Arctium lappa, and then enzymolyzed into arctigenin. The obtained arctiin and arctigenin were characterized and then used as standards for their determination in the crude drug by HPLC. The method is simple, rapid and accurate.

Benzyl Compounds↗
PubMed1992

Aging of the human retina. Differential loss of neurons and retinal pigment epithelial cells.

The impact of aging on cell loss in the human retina was examined in foveal and temporal equatorial regions in eyes from 35 donors with ages spanning a 78-yr period from the second to the ninth decade of life. Equatorial cones and retinal pigment epithelial cells (RPE) decreased at uniform rates from the second to the ninth decade, 16 and 14 cells/mm2/yr, respectively. Equatorial rods and cells in the ganglion cell layer (GCL) showed nonuniform rate decreases with age. The rates of rod and GCL cell loss were faster between the second and fourth decades (970 and 9 cells/mm2/yr, respectively) than between the fourth and ninth decades (570-330 and 6-3 cells/mm2/yr). The rod and GCL cell densities at the temporal equator maintained a constant ratio (rods-GCL cell ratio = 103 +/- 0.4, mean +/- standard deviation) and the same reduction slope ratio at different times during aging. Thus, the equatorial rod and GCL cell losses were correlated statistically. The ratio of equatorial photoreceptors to RPE cells showed no significant change with age, suggesting parallel loss of these closely apposed cells. At the foveal center, the variability of cone density between individuals in each decade grouping was large (1.7- to threefold). No significant differences were found in cone or RPE cell densities at the foveal center from the second to ninth decade, suggesting that the densities of foveal cones and RPE cells were stable throughout this period. Foveal RPE density was significantly higher than equatorial RPE density in each age group. No significant difference was found between the equatorial photoreceptor-RPE ratio and foveal cone-RPE ratio in any age group. Cells in the GCL in the fovea decreased by approximately 16% from the second to the sixth decade. These results indicated that (1) rod photoreceptors and cells in the GCL were more vulnerable to loss during aging than cones; (2) photoreceptors and RPE cells showed parallel changes during aging; and (3) the photoreceptor loss accompanying aging was less pronounced in the fovea than in the peripheral retina.

Adolescent↗
PubMed1991

Physical factors contributing to the partition coefficient and retention time of 2',3'-dideoxynucleoside analogues.

Acquired immunodeficiency syndrome (AIDS) is an immunosuppressive disease characterized by an immune impairment and a high susceptibility to unusual forms of certain neoplasms. Since the brain is an important site of the infection, it is necessary to explore new classes of drugs that have the ability to penetrate across the blood-brain barrier, and the potency to suppress viral replication within the central nervous system (CNS). Therefore, the ability to predicate the lipophilicity of the potent anti-AIDS drugs may provide useful information about the potential of the drugs to enter CNS. In this paper, the correlations of log P (octanol-buffer partition coefficient) and log tR (retention time in HPLC; Rt was used by Balzarini et al.) with some physical constants like log MW (molecular weight), hydrogen bond forming ability (HB) of the substituents, and the substituent group dipole moments (mu) are analyzed. Good correlations of log P and log tR with log MW, HB, and mu have been obtained.

Antiviral Agents↗
PubMed1991

The clinical and biological significance of the transitional mucosa adjacent to colorectal cancer.

The underlying nature of the transitional mucosa adjacent to colorectal cancer is defined and the evidence for and against the statement that this transitional mucosa involves primary premalignant change presented in this article. An association between mucin histochemical changes at the margins of resection and a poorer clinical outcome of patients has been recognized in patients with colorectal cancer after surgery. The retained transitional mucosa at the margins of resection appears to correlate with tumor recurrence and a poorer survival in patients who have undergone radical resection. It is considered that the transitional mucosa adjacent to colorectal cancer and its presence at the margins of resection may be an important prognostic marker for patients with large bowel cancer following radical resection.

Biomarkers, Tumor↗
PubMed1991

Quantitative structure-activity relationship analysis of combretastatins: a class of novel antimitotic agents.

Combretastatins and their synthetic analogues, having structural features resembling that of colchicine, also have similar modes of action. In this report we have correlated the cytotoxicity of combretastatins against the murine leukemic cell line L1210 with physicochemical parameters such as the summation of the Hansch-Fujita pi constant, which was used as an index of lipophilicity of the substituent groups on ring A (sigma pi a) and ring B (sigma pi b), the vector summation of the group dipole moments of ring A (sigma mu a) and ring B (sigma mu b), the nature of the linker chain between ring A and ring B (Bt-L), indicator parameters (NOH)a and (NOH)b, which represent the number of hydroxyl groups on ring A and ring B, respectively, and the summation of pi values of the substituents on the linker (sigma pi L). Cytotoxicity correlated well with (sigma pi b), (NOH)a, (Bt-L), and (sigma mu b), and the dependency on (sigma pi b) was found to be parabolic.

Animals↗
PubMed1991

Quantitative structure-activity relationship (QSAR) analysis of the cytotoxicities of aminohydroxyguanidine derivatives and their antiviral activities in vitro.

Substituted Schiff bases of 1-amino-3-hydroxyguanidine (SB-HAG) were tested for the first time against noninfected T4 lymphocytes (CEM-6 cells) and the same cell line infected by HIV-1 in vitro. Twenty-one of 23 compounds at micromolar levels did not inhibit the growth of the noninfected T4 cells, suggesting minimal cytotoxicity. The antiviral effects of these compounds in a micromolar concentration range have been shown to be nonsignificant (less than 30%) against HIV-1. Three-dimensional parameter focusing of the physicochemical properties (i.e., log P and VW) and the marginal antiviral activities shows that the marginally active compounds lie in a region different from the inactive compounds. QSAR analysis of the two subsets shows that the cytotoxicity correlates well with the electronic and lipophilic parameters. The results of the QSAR analysis can serve as guidelines for further structural modification of this series of compounds to minimize the cytotoxicity against host cells.

Antiviral Agents↗
PubMed1991

[A study using FRTL-5 cell for detecting thyroid stimulating antibody activity in serum in patients with Graves disease].

Using a strain of functioning rat thyroid cells (Fischer rat thyroid line-5, FRTL-5) as target cells and immunoglobin G sedimented from serum by polyethylene glycol (PEG), we studied thyroid stimulating antibody (TsAb) activity in serum of patients with Graves' disease. In a total of 92 cases, TsAb activity was detected in 92.59% (25/27) of the patients with untreated Graves' disease, 75.00% (9/12) of the patients with relapsing Graves' disease and 39.13% (18/46) of the patients with Graves' disease who were euthyroid while taking antithyroid drugs. TsAb activity was also detected in 42.86% (3/7) of the patients with ophthalmic Graves' disease and 12.50% (2/16) of the patients with Hashimoto's thyroiditis. The results showed that TsAb activity can be used as an immunologic index and is valuable in the diagnosis of Graves' disease. Remission and relapse of Graves' disease can be indicated or monitored with the measurement of TsAb activity.

Adolescent↗
PubMed1991

[The study of dermatoglyphic parameters on 1000 Tibetans].

This paper reports 14 dermatoglyphic parameters of 1000 Tibetans sampled in Tibet. Relatedness between Tibetans and Hans is much closer than that between Tibetans and Minnesotians in the USA. Compared with 12 nationalities. The Tibetan showed smaller difference with the Hani and the Han and greater difference with the Uygur. Comparison among the Tibetans living in different regions suggests that the Tibetans in Tibet have less difference with the Tibetans in Pingwu Region of Sichuan Province and much difference with the Tibetans in Gannan Region of Gansu Province. This report indicates that dermatoglyphic Parameters should not be used indifferently in different ethnic groups or even in different geographic groups of the same nationality.

Adolescent↗
PubMed1991

Clinical observations on acupuncture treatment of peripheral facial paralysis aided by infra-red thermography--a preliminary report.

We have carried out clinical observations on 34 patients with peripheral facial paralysis treated by acupuncture therapy prescribed according to selection of treatment regimen on the basis of facial thermogram and temperature. A comparison was made with a control group of 97 patients who received conventional acupuncture therapy only. It was found that 1) The cure rate in the group of selecting acupoints by thermogram (hereinafter referred to as the thermography--aided treatment group) was 67.65%, with a marked improvement rate of 26.40%; while the cure rate of the conventional acupuncture treatment group (hereinafter called the conventional treatment group) was 46.39%, the marked improvement rate being 29.90%, indicating a significant difference in therapeutic efficacy between the two groups (P less than 0.02). 2) The average duration of acupuncture therapy for the thermography aided treatment group was 6.02 weeks, whereas that for the conventional treatment group, 24 weeks. There was also a significant difference between the two groups (P less than 0.01). And 3) During the entire therapeutic course, 25.2 sessions of treatment were given on the average in the thermography--aided treatment group, and 78.8 sessions in the conventional treatment group, showing a very significant difference (P less than 0.001). The present thermography--aided method exhibits advantages over the conventional one in enhancing the cure rate and shortening the duration of treatment, which is worthy to be popularized in clinical practice. And it is also of certain significance in standardization and scientification of acupuncture therapy.

Acupuncture Points↗
PubMed1991

[The thermographic observation of the relationship between the retention of acupuncture needles and the effect of nose temperatures].

This is an observation of the relationship between the retention of acupuncture needles and its effect on nose temperature in seventy-four patients with facial nerve paralysis. The patients were divided into five groups according to the period of retention of needles: no retention, retention for ten, twenty, thirty and fourty minutes. Every group consisted twenty cases. The results showed that (a) the nose temperature lowered after acupuncture immediately; (b) then it rose and reached to the maximum at twenty minutes after acupuncture, then lowered again; (c) for the group of no retention and retention for ten and twenty minutes, the temperature rose again during thirty to fourty minutes after acupuncture, for the group of retention for thirty or fourty minutes, however, without these phenomena; (d) the general tendency was that the change of temperature was bigger but lasting for shorter period in the groups of retention for longer time than that in the groups of retention for shorter time. These results verified that some theories in ancient books about the retention of acupuncture needles are scientific.

Acupuncture Therapy↗
PubMed1990

Sialomucin at the resection margins and likelihood of local recurrence of carcinoma of the rectum after anterior resection.

The histochemical changes in mucin at the postoperative resection margins in carcinoma of the upper and middle third of the rectum after anterior resection were studied retrospectively in 52 patients. The sialomucinous change was most likely to occur at the intestinal margins of those patients who had tumour recurrence (P less than 0.001). The histological types of tumour, degree of differentiation, Dukes' stages and their distance from the anal verge were virtually the same in patients with and without tumour recurrence. By using high iron diamine-alcian blue staining technique we identified patients with higher risk conditions of tumour recurrence after anterior resection. This technique should increase the likelihood of a cure for patients with recurrent carcinoma of the rectum after anterior resection.

Carcinoma↗
PubMed1990

[Determination of lymphocyte subsets in pulmonary tuberculosis by Mc-Ab- rosette reagent method].

The lymphocyte subsets in peripheral blood were determined in 73 cases of active pulmonary tuberculosis and 40 healthy subjects using rosette reagent of monoclonal antibody (McAb) to anti-T lymphocyte. The results showed that the percentages of T3, T4, T8, and T4/T8 ratio were 54.3 +/- 6.7%, 34.3 +/- 7.9%, 35.5 +/- 10.0%, 1.0 +/- 0.4 of patients group 66.3 +/- 7.9%, 45.3 +/- 6.3%, 29.9 +/- 5.8% and 1.6 +/- 0.3 of healthy control group respectively. There was statistically significant difference between these two groups (P less than 0.01).

Adult↗